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Title:ADC values as a biomarker of fetal brain maturation
Authors:ID Kobal, Lucija (Author)
ID Šurlan Popović, Katarina (Author)
ID Avsenik, Jernej (Author)
ID Vipotnik-Vesnaver, Tina (Author)
Files:URL URL - Source URL, visit https://www.radioloncol.com/index.php/ro/article/view/4043/5151
 
.pdf PDF - Presentation file, download (1,41 MB)
MD5: C93263A9E3C090F9ABC451EBA997981C
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background. During the period of fetal development, myelination plays a key role and follows specific time and spa-tial sequences. The water content in the brain is inversely proportional to myelination – the more myelinated the brain, the lower the water content in it. The diffusion of water molecules can be quantitatively assessed using the apparent diffusion coefficient (ADC). We were interested in whether, by determining the ADC values, we could quantitatively evaluate the development of the fetal brain. Patients and methods. The study included 42 fetuses with gestational age 25 to 35 weeks. We manually selected 13 regions on diffusion-weighted images. Statistically significant differences between ADC values were checked using one-way analysis of variance and Tukey’s post hoc test. The relationship between the ADC values and the gestational age of the fetuses was then assessed using linear regression. Results. The average gestational age of the fetuses was 29.8 ± 2.4 weeks. ADC values in the thalami, pons and cerebellum differed significantly among each other and from the ADC values in other brain regions. In the thalami, pons and cerebellum, linear regression showed a significant decrease in ADC values with increasing gestational age. Conclusions. ADC values change with the increasing gestational age of the fetus and differ among different brain regions. In the pons, cerebellum and thalami, the ADC coefficient could be used as a biomarker of fetal brain matura-tion since ADC values decrease linearly with increasing gestational age.
Keywords:myelination, fetal brain maturation, ADC, biomarker, diffusion-weighted imaging, diffusion
Publication status:Published
Publication version:Version of Record
Publication date:01.06.2023
Publisher:Association of Radiology and Oncology
Year of publishing:2023
Number of pages:str. 178-183
Numbering:Vol. 57, no. 2
Source:Ljubljana
PID:20.500.12556/DiRROS-19841 New window
UDC:616-006
ISSN on article:1318-2099
DOI:10.2478/raon-2023-0022 New window
COBISS.SI-ID:165016579 New window
Copyright:by Authors
Note:Soavtorji: Katarina Surlan Popovic, Jernej Avsenik, Tina Vipotnik Vesnaver;
Publication date in DiRROS:25.07.2024
Views:341
Downloads:227
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:mielinizacija, zorenje možganov ploda, biološki označevalec, difuzijsko uteženo MRI, difuzija


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