| Title: | Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer |
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| Authors: | ID Vidic, Zala (Author)
ID Goričar, Katja (Author)
ID Stražišar, Branka (Author)
ID Bešić, Nikola (Author)
ID Dolžan, Vita (Author) |
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| Files: |  URL - Source URL, visit https://www.radioloncol.com/index.php/ro/article/view/3995/5144
 PDF - Presentation file, download (1,48 MB)
MD5: D69681ECC149E533E04F7A38AB105032
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Background. Tramadol is an opioid analgesic often used for pain management after breast cancer surgery. Its anal-gesic activity is due to the activation of the μ-opioid receptor, encoded by the OPRM1 gene. This study investigated the association of genetic variability in OPRM1 and its regulatory miRNA genes with outcomes of tramadol/paraceta-mol treatment after breast cancer surgery with axillary lymphadenectomy.Patients and methods. The study included 113 breast cancer patients after breast cancer surgery with axillary lymphadenectomy treated with either 75/650 mg or 37.5/325 mg of tramadol with paracetamol for pain relief within the randomized clinical trial KCT 04/2015-DORETAonko/si at the Institute of Oncology Ljubljana. All patients were geno-typed for OPRM1 rs1799971 and rs677830, MIR23B rs1011784, and MIR107 rs2296616 using competitive allele-specific PCR. The association of genetic factors with acute and chronic pain as well as adverse effects of tramadol treatment was evaluated using logistic regression, Fisher’s exact test, and Mann-Whitney test.Results.The investigated OPRM1 related polymorphisms were not associated with acute pain assessed with the VAS scale within four weeks after surgery (all P > 0.05). Carriers of at least one polymorphic OPRM1 rs1799971 allele had a higher risk of constipation in the first four weeks after surgery compared to non-carriers (OR = 4.5, 95% CI = 1.6–12.64, P = 0.004). Carriers of at least one polymorphic OPRM1 rs677830 allele had a higher risk of constipation after third week of tramadol treatment (OR = 3.11, 95% CI = 1.08–8.89, P = 0.035). Furthermore, carriers of two polymorphic MIR23Brs1011784 alleles had a higher risk of nausea after 28 days of tramadol treatment (OR = 7.35, 95% CI = 1.27–42.6, P = 0.026), while heterozygotes for MIR107 rs2296616 allele had a lower risk of nausea after 21 days of tramadol treatment (OR = 0.21, 95% CI = 0.05–0.87, P = 0.031). In carriers of two polymorphic MIR107 rs2296616 alleles, chronic pain was significantly more common than in carriers of two wild-type alleles (P = 0.004). Carriers of at least one polymorphic MIR23B rs1011784 allele experienced more neuropathic pain after adjustment for tramadol dose (OR = 2.85, 95% CI = 1.07–7.59, P = 0.036), while carriers of at least one polymorphic OPRM1 rs677830 allele experienced less neuropathic pain compared to carriers of two wild-type alleles (OR = 0.38, 95% CI = 0.15–0.99, P = 0.047).Conclusions.Genetic variability of OPRM1 and genes coding for miRNAs that could affect OPRM1 expression may be associated with adverse effects of tramadol/paracetamol treatment as well as with chronic and neuropathic pain after breast cancer surgery with axillary lymphadenectomy. |
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| Keywords: | operacija raka na dojki, zdravljenje bolečine, tramadol |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2023 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2023 |
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| Number of pages: | str. 111-120, XII |
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| Numbering: | Vol. 57, no. 1 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-19828  |
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| UDC: | 617-089:616-009.7 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.2478/raon-2023-0003 |
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| COBISS.SI-ID: | 146440963 |
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| Copyright: | by Authors |
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| Note: | Soavtorji: Katja Goricar, Branka Strazisar, Nikola Besic, Vita Dolzan;
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| Publication date in DiRROS: | 25.07.2024 |
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| Views: | 872 |
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| Downloads: | 237 |
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