| Naslov: | Diagnostic performance of p16/Ki-67 dual immunostaining at different number of positive cells in cervical smears in women referred for colposcopy |
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| Avtorji: | ID Salobir Gajšek, Uršula (Avtor)
ID Dovnik, Andraž (Avtor)
ID Takač, Iztok (Avtor)
ID Ivanuš, Urška (Avtor)
ID Jerman, Tine (Avtor)
ID Šramek Zatler, Simona (Avtor)
ID Repše-Fokter, Alenka (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (441,03 KB)
MD5: 41B9F7BC8F3B144133EDA11E722F9FB2
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | . The aim of the study was to evaluate the diagnostic accuracy of p16/Ki-67 dual immunostaining (p16/ Ki-67 DS) in cervical cytology and the number of positive p16/Ki-67 cells to diagnose high grade cervical intraepithelial neoplasia (CIN2+) in colposcopy population. Subjects and methods. We performed an analysis on a subset cohort of 174 women enrolled within a large-scale randomised controlled human papillomavirus (HPV) self-sampling project organised as part of the population-based Cervical Cancer Screening Programme ZORA in Slovenia. This subset cohort of patients was invited to the colposcopy clinic, underwent p16/Ki-67 DS cervical cytology and had the number of p16/Ki-67 positive cells determined. Results. Among analysed women, 42/174 (24.1%) had histologically confirmed CIN2+. The risk for CIN2+ was increasing with the number of positive cells (p < 0.001). The sensitivity of p16/Ki-67 DS for detection of CIN2+ was 88.1%, specificity was 65.2%, positive predictive value was 44.6% and negative predictive value was 94.5%. Conclusions. Dual p16/Ki-67 immunostaining for the detection of CIN2+ has shown high sensitivity and high negative predictive value in our study, which is comparable to available published data. The number of p16/Ki-67 positive cells was significantly associated with the probability of CIN2+ detection. We observed a statistically significant and clinically relevant increase in specificity if the cut-off for a positive test was shifted from one cell to three cells. |
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| Ključne besede: | cervical cytology, high-grade dysplasia, p16/Ki-67 immunostaining |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.01.2021 |
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| Založnik: | Association of Radiology and Oncology |
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| Leto izida: | 2021 |
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| Št. strani: | str. 426-432, IV |
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| Številčenje: | Vol. 55, no. 4 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-19623  |
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| UDK: | 616-07 |
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| ISSN pri članku: | 1318-2099 |
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| DOI: | 10.2478/raon-2021-0043 |
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| COBISS.SI-ID: | 89445891 |
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| Avtorske pravice: | by Authors |
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| Opomba: | Soavtorji: Andraz Dovnik, Iztok Takac, Urska Ivanus, Tine Jerman, Simona Sramek Zatler, Alenka Repse Fokter;
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| Datum objave v DiRROS: | 22.07.2024 |
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| Število ogledov: | 13 |
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| Število prenosov: | 3 |
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| Metapodatki: |     |
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