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Naslov:Can dynamic imaging, using 18F-FDG PET/CT and CT perfusion differentiate between benign and malignant pulmonary nodules?
Avtorji:ID Marin, Aleksander (Avtor)
ID Murchison, John T. (Avtor)
ID Skwarski, Kristopher M. (Avtor)
ID Tavares, Adriana A.S. (Avtor)
ID Fletcher, Alison (Avtor)
ID Wallace, William A. (Avtor)
ID Salapura, Vladka (Avtor)
ID Van Beek, Edwin J.R. (Avtor)
ID Mirsadraee, Saeed (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (707,02 KB)
MD5: C72D1781598AF9CF0E875499F652036A
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. The aim of the study was to derive and compare metabolic parameters relating to benign and ma- lignant pulmonary nodules using dynamic 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG) PET/CT, and nodule perfu- sion parameters derived through perfusion computed tomography (CT). Patients and methods. Twenty patients with 21 pulmonary nodules incidentally detected on CT underwent a dynamic 18F-FDG PET/CT and a perfusion CT. The maximum standardized uptake value (SUVmax) was measured on conventional 18F-FDG PET/CT images. The influx constant (Ki) was calculated from the dynamic 18F-FDG PET/CT data using Patlak model. Arterial flow (AF) using the maximum slope model and blood volume (BV) using the Patlak plot method for each nodule were calculated from the perfusion CT data. All nodules were characterized as malignant or benign based on histopathology or 2 year follow up CT. All parameters were statistically compared between the two groups using the nonparametric Mann-Whitney test. Results. Twelve malignant and 9 benign lung nodules were analysed (median size 20.1 mm, 9-29 mm) in 21 patients (male/female = 11/9; mean age +- SD: 65.3 +- 7.4; age range: 50-76 years). The average SUVmax values +- SD of the benign and malignant nodules were 2.2 +- 1.7 vs. 7.0 +- 4.5, respectively (p = 0.0148). Average Ki values in benign and malig- nant nodules were 0.0057 +- 0.0071 and 0.0230 +- 0.0155 min-1, respectively (p = 0.0311). Average BV for the benign and malignant nodules were 11.6857 +- 6.7347 and 28.3400 +- 15.9672 ml/100 ml, respectively (p = 0.0250). Average AF for the benign and malignant nodules were 74.4571 +- 89.0321 and 89.200 +- 49.8883 ml/100g/min, respectively (p = 0.1613). Conclusions. Dynamic 18F-FDG PET/CT and perfusion CT derived blood volume had similar capability to differentiate benign from malignant lung nodules.
Ključne besede:CT perfusion, malignant pulmonary nodules, benign pulmonary nodules
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.2021
Založnik:Association of Radiology and Oncology
Leto izida:2021
Št. strani:str. 259-267, II
Številčenje:Vol. 55, no. 3
Izvor:Ljubljana
PID:20.500.12556/DiRROS-19616 Novo okno
UDK:616.2
ISSN pri članku:1318-2099
DOI:10.2478/raon-2021-0024 Novo okno
COBISS.SI-ID:74670595 Novo okno
Avtorske pravice:by Authors
Opomba:Soavtorji: John T. Murchison, Kristopher M. Skwarski, Adriana A.S. Tavares, Alison Fletcher, William A. Wallace, Vladka Salapura, Edwin J.R. van Beek, Saeed Mirsadraee;
Datum objave v DiRROS:22.07.2024
Število ogledov:421
Število prenosov:150
Metapodatki:XML DC-XML DC-RDF
:
MARIN, Aleksander, MURCHISON, John T., SKWARSKI, Kristopher M., TAVARES, Adriana A.S., FLETCHER, Alison, WALLACE, William A., SALAPURA, Vladka, VAN BEEK, Edwin J.R. in MIRSADRAEE, Saeed, 2021, Can dynamic imaging, using 18F-FDG PET/CT and CT perfusion differentiate between benign and malignant pulmonary nodules? Radiology and oncology [na spletu]. 2021. Vol. 55, no. 3, p. 259–267, ii. [Dostopano 8 april 2025]. DOI 10.2478/raon-2021-0024. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=19616
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:polimorfizmi, CT perfuzija, maligni pljučni vozliči, benigni pljučni vozliči


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