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Naslov:CCR5-mediated signaling is involved in invasion of glioblastoma cells in its microenvironment
Avtorji:ID Novak, Metka (Avtor)
ID Koprivnikar Krajnc, Miha (Avtor)
ID Hrastar, Barbara (Avtor)
ID Breznik, Barbara (Avtor)
ID Majc, Bernarda (Avtor)
ID Mlinar, Mateja (Avtor)
ID Rotter, Ana (Avtor)
ID Porčnik, Andrej (Avtor)
ID Mlakar, Jernej (Avtor)
ID Stare, Katja (Avtor)
ID Pestell, Richard G. (Avtor)
ID Lah Turnšek, Tamara (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/1422-0067/21/12/4199
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:Abstract The chemokine CCL5/RANTES is a versatile inflammatory mediator, which interacts with the receptor CCR5, promoting cancer cell interactions within the tumor microenvironment. Glioblastoma is a highly invasive tumor, in which CCL5 expression correlates with shorter patient survival. Using immunohistochemistry, we identified CCL5 and CCR5 in a series of glioblastoma samples and cells, including glioblastoma stem cells. CCL5 and CCR5 gene expression were significantly higher in a cohort of 38 glioblastoma samples, compared to low-grade glioma and non-cancerous tissues. The in vitro invasion of patients-derived primary glioblastoma cells and glioblastoma stem cells was dependent on CCL5-induced CCR5 signaling and is strongly inhibited by the small molecule CCR5 antagonist maraviroc. Invasion of these cells, which was enhanced when co-cultured with mesenchymal stem cells (MSCs), was inhibited by maraviroc, suggesting that MSCs release CCR5 ligands. In support of this model, we detected CCL5 and CCR5 in MSC monocultures and glioblastoma-associated MSC in tissue sections. We also found CCR5 expressing macrophages were in close proximity to glioblastoma cells. In conclusion, autocrine and paracrine cross-talk in glioblastoma and, in particular, glioblastoma stem cells with its stromal microenvironment, involves CCR5 and CCL5, contributing to glioblastoma invasion, suggesting the CCL5/CCR5 axis as a potential therapeutic target that can be targeted with repositioned drug maraviroc.
Ključne besede:CCL5, CCR5, chemokines, glioblastoma, invasion, maraviroc, mesenchymal stem cells
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:12.06.2020
Leto izida:2020
Št. strani:str. 1-20
Številčenje:Vol. 21, iss. 12
PID:20.500.12556/DiRROS-19518 Novo okno
UDK:577
ISSN pri članku:1422-0067
COBISS.SI-ID:19416067 Novo okno
Opomba:Nasl. z nasl. zaslona; Opis vira z dne 12. 6. 2020;
Datum objave v DiRROS:22.07.2024
Število ogledov:542
Število prenosov:190
Metapodatki:XML DC-XML DC-RDF
:
NOVAK, Metka, KOPRIVNIKAR KRAJNC, Miha, HRASTAR, Barbara, BREZNIK, Barbara, MAJC, Bernarda, MLINAR, Mateja, ROTTER, Ana, PORČNIK, Andrej, MLAKAR, Jernej, STARE, Katja, PESTELL, Richard G. in LAH TURNŠEK, Tamara, 2020, CCR5-mediated signaling is involved in invasion of glioblastoma cells in its microenvironment. International journal of molecular sciences [na spletu]. 2020. Vol. 21, no. 12, p. 1–20. [Dostopano 25 april 2025]. Pridobljeno s: https://www.mdpi.com/1422-0067/21/12/4199
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Gradivo je del revije

Naslov:International journal of molecular sciences
Skrajšan naslov:Int. j. mol. sci.
Založnik:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P1-0245-2019
Naslov:Ekotoksiologija, toksikološka genomika in karcinogeneza
Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:Z3-1870-2019
Naslov:Vpliv mezenhimskih matičnih celic na odpornost glioblastoma na terapijo

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:glioblastom, kemokini, tumorsko mikrookolje, invazija


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