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Title:DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
Authors:ID Bonassi, Stefano (Author)
ID Ceppi, Marcello (Author)
ID Møller, Peter (Author)
ID Azqueta, Amaya (Author)
ID Milić, Mirta (Author)
ID Brunborg, Gunnar (Author)
ID Koppen, Gudrun (Author)
ID Bruzzone, Marco (Author)
ID Silva, Juliana Da (Author)
ID Benedetti, Danieli (Author)
ID Moretti, Silvia (Author)
ID Riso, Patrizia (Author)
ID Russo, Patrizia (Author)
ID Marcos, Ricardo (Author)
ID Gajski, Goran (Author)
ID Spremo-Potparević, Biljana (Author)
ID Živković, Lada (Author)
ID Boutet-Robinet, Elisa (Author)
ID Dusinska, Maria (Author)
ID Collins, Andrew (Author)
ID Žegura, Bojana (Author)
Files:URL URL - Source URL, visit https://www.nature.com/articles/s41598-021-95976-7
 
.pdf PDF - Presentation file, download (1,08 MB)
MD5: F83D0B9859CA0D78DDC6DA29FE7ABCF7
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo NIB - National Institute of Biology
Abstract:The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06–1.90) for overall mortality, and 1.94 (1.04–3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases.
Publication status:Published
Publication version:Version of Record
Publication date:18.08.2021
Year of publishing:2021
Number of pages:str. 1-11
Numbering:Vol. 11
PID:20.500.12556/DiRROS-19464 New window
UDC:577
ISSN on article:2045-2322
DOI:10.1038/s41598-021-95976-7 New window
COBISS.SI-ID:74105859 New window
Note:Nasl. z nasl. zaslona; Opis vira z dne 26. 8. 2021; Št. članka: 16793;
Publication date in DiRROS:19.07.2024
Views:516
Downloads:289
Metadata:XML DC-XML DC-RDF
:
BONASSI, Stefano, CEPPI, Marcello, MØLLER, Peter, AZQUETA, Amaya, MILIĆ, Mirta, BRUNBORG, Gunnar, KOPPEN, Gudrun, BRUZZONE, Marco, SILVA, Juliana Da, BENEDETTI, Danieli, MORETTI, Silvia, RISO, Patrizia, RUSSO, Patrizia, MARCOS, Ricardo, GAJSKI, Goran, SPREMO-POTPAREVIĆ, Biljana, ŽIVKOVIĆ, Lada, BOUTET-ROBINET, Elisa, DUSINSKA, Maria, COLLINS, Andrew and ŽEGURA, Bojana, 2021, DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death. Scientific reports [online]. 2021. Vol. 11, p. 1–11. [Accessed 7 April 2025]. DOI 10.1038/s41598-021-95976-7. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19464
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Record is a part of a journal

Title:Scientific reports
Shortened title:Sci. rep.
Publisher:Nature Publishing Group
ISSN:2045-2322
COBISS.SI-ID:18727432 New window

Document is financed by a project

Funder:EC - European Commission
Funding programme:COST Action
Project number:CA15132
Acronym:hCOMET
Funder:Other - Other funder or multiple funders
Funding programme:Italian Ministry of Health for Institutional Research

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:biokemija, poškodbe DNK, levkociti, testiranje


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