| Title: | Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres |
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| Authors: | ID Breznik, Barbara (Author)
ID Ko, Meng-Wei (Author)
ID Tse, Christopher (Author)
ID Chen, Po-Chun (Author)
ID Senjor, Emanuela (Author)
ID Majc, Bernarda (Author)
ID Habič, Anamarija (Author)
ID Angelillis, Nicolas (Author)
ID Novak, Metka (Author)
ID Župunski, Vera (Author)
ID Mlakar, Jernej (Author)
ID Nathanson, David (Author)
ID Jewett, Anahid (Author) |
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| Files: |  URL - Source URL, visit https://www.arrs.si/sl/promocija/odlicni/inc/22/odlicni-22-3.pdf
URL - Source URL, visit https://doi.org/10.1038/s42003-022-03402-z
 PDF - Presentation file, download (10,81 MB)
MD5: 916522731EC60E747674F15A420F7970
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  NIB - National Institute of Biology
 IJS - Jožef Stefan Institute
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| Abstract: | Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since these cells can select and lyse therapy-resistant glioblastoma stem-like cells (GSLCs). Immunotherapy with super-charged NK cells has a potential as antitumor approach since we found their efficiency to kill patient-derived GSLCs in 2D and 3D models, potentially reversing the immunosuppression also seen in the patients. In addition to their potent cytotoxicity, NK cells secrete IFN-γ, upregulate GSLC surface expression of CD54 and MHC class I and increase sensitivity of GSLCs to chemotherapeutic drugs. Moreover, NK cell localization in peri-vascular regions in glioblastoma tissues and their close contact with GSLCs in tumorospheres suggests their ability to infiltrate glioblastoma tumors and target GSLCs. Due to GSLC heterogeneity and plasticity in regards to their stage of differentiation personalized immunotherapeutic strategies should be designed to effectively target glioblastomas. |
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| Keywords: | glioblastoma, natural killer cells, translational oncology |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 10.05.2022 |
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| Year of publishing: | 2022 |
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| Number of pages: | str. 1-15 |
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| Numbering: | Vol. 5 |
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| PID: | 20.500.12556/DiRROS-19321  |
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| UDC: | 616-006 |
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| ISSN on article: | 2399-3642 |
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| DOI: | 10.1038/s42003-022-03402-z |
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| COBISS.SI-ID: | 107677443 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 13. 5. 2022;
Ostali avtorji: Meng-Wei Ko, Christopher Tse, Po-Chun Chen, Emanuela Senjor, Bernarda Majc, Anamarija Habič, Nicolas Angelillis, Metka Novak, Vera Župunski, Jernej Mlakar, David Nathanson & Anahid Jewett;
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| Publication date in DiRROS: | 16.07.2024 |
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| Views: | 157 |
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| Downloads: | 135 |
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