| Title: | New insights in ATP synthesis as therapeutic target in cancer and angiogenic ocular diseases |
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| Authors: | ID Noorden, Cornelis J. F. van (Author)
ID Yetkin-Arik, Bahar (Author)
ID Serrano Martinez, Paola (Author)
ID Bakker, Noëlle (Author)
ID Breest Smallenburg, Mathilda E. van (Author)
ID Schlingemann, Reinier O. (Author)
ID Klaassen, Ingeborg (Author)
ID Majc, Bernarda (Author)
ID Habič, Anamarija (Author)
ID Bogataj, Urban (Author)
ID Galun, Katrin S. (Author)
ID Vittori, Miloš (Author)
ID Erdani-Kreft, Mateja (Author)
ID Novak, Metka (Author)
ID Breznik, Barbara (Author)
ID Hira, Vashendriya V. V. (Author) |
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| Files: |  URL - Source URL, visit https://doi.org/10.1369/00221554241249515
 PDF - Presentation file, download (3,75 MB)
MD5: 31C5087AE9BFCAD3C92294006360F688
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  NIB - National Institute of Biology
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| Abstract: | Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and cancer cells, need lactate for the biosynthesis of building blocks for cell growth and tissue expansion. Moreover, both non-proliferating cancer stem cells in tumors and leader tip ECs during angiogenesis rely on glycolysis for pyruvate production, which is used for ATP synthesis in mitochondria through oxidative phosphorylation (OXPHOS). Therefore, aerobic glycolysis is not a specific hallmark of cancer but rather a hallmark of proliferating cells and limits its utility in cancer therapy. However, local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation. Most types of cells in the eye such as photoreceptors and pericytes use OXPHOS for ATP production, whereas proliferating angiogenic stalk ECs rely on glycolysis for lactate and ATP production. |
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| Keywords: | aerobic glycolysis, anaerobic glycolysis, angiogenesis, ATP synthesis, cancer cells, cancer stem cells, endothelial cells, energy metabolism, eye diseases, oxidative phosphorylation, pericytes, retina, Warburg effect |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.05.2024 |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 329-352 |
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| Numbering: | Vol. 72, iss. 5 |
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| PID: | 20.500.12556/DiRROS-19117  |
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| UDC: | 576 |
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| ISSN on article: | 0022-1554 |
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| DOI: | 10.1369/00221554241249515 |
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| COBISS.SI-ID: | 199290115 |
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| Note: | Soavtorji: Bahar Yetkin-Arik, Paola Serrano Martinez, Noëlle Bakker, Mathilda E. van Breest Smallenburg, Reinier O. Schlingemann, Ingeborg Klaassen, Bernarda Majc, Anamarija Habič, Urban Bogataj, S. Katrin Galun, Miloš Vittori, Mateja Erdani Kreft, Metka Novak, Barbara Breznik, and Vashendriya V.V. Hira;
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| Publication date in DiRROS: | 18.06.2024 |
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| Views: | 426 |
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| Downloads: | 224 |
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