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Title:Interval cancers after negative immunochemical test compared to screen and non-respondersʼ detected cancers in Slovenian colorectal cancer screening programme
Authors:ID Novak-Mlakar, Dominika (Author)
ID Kofol-Bric, Tatjana (Author)
ID Škrjanec, Ana Lucija (Author)
ID Krajc, Mateja (Author)
Files:.pdf PDF - Presentation file, download (288,68 KB)
MD5: 529DFA8C25AAE844CE1360C47473D91F
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:We assessed the incidence and characteristics of interval cancers after faecal immunochemical occult blood test and calculated the test sensitivity in Slovenian colorectal cancer screening programme. Patients and methods. The analysis included the population aged between 50 to 69 years, which was invited for screening between April 2011 and December 2012. The persons were followed-up until the next foreseen invitation, in average for 2 years. The data on interval cancers and cancers in non-responders were obtained from cancer registry. Gender, age, years of schooling, the cancer site and stage were compared among three observed groups. We used the proportional incidence method to calculate the screening test sensitivity. Results. Among 502,488 persons invited for screening, 493 cancers were detected after positive screening test, 79 interval cancers after negative faecal immunochemical test and 395 in non-responders. The proportion of interval cancers was 13.8%. Among the three observed groups cancers were more frequent in men (p = 0.009) and in persons aged 60+ years (p < 0.001). Comparing screen detected and cancers in non-responders with interval cancers more interval cancers were detected in persons with 10 years of schooling or more (p = 0.029 and p = 0.001), in stage III (p = 0.027) and IV (p < 0.001), and in right hemicolon (p < 0.001). Interval cancers were more frequently in stage I than non-responders cancers (p = 0.004). Test sensitivity of faecal immunochemical test was 88.45%. Conclusions. Interval cancers in Slovenian screening programme were detected in expected proportions as in similar programmes. Test sensitivity was among the highest when compared to similar programmes and was accomplished using test kit for two stool samples.
Keywords:cancer screening, colorectal cancer, faecal immunochemical test, test sensitivity
Publication status:Published
Publication version:Version of Record
Publication date:01.12.2018
Publisher:Association of Radiology and Oncology
Year of publishing:2018
Number of pages:str. 413-421, V
Numbering:Vol. 52, no. 4
Source:Ljubljana
PID:20.500.12556/DiRROS-19078 New window
UDC:614
ISSN on article:1318-2099
DOI:10.2478/raon-2018-0025 New window
COBISS.SI-ID:2983803 New window
Copyright:by Authors
Publication date in DiRROS:10.06.2024
Views:536
Downloads:137
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:
NOVAK-MLAKAR, Dominika, KOFOL-BRIC, Tatjana, ŠKRJANEC, Ana Lucija and KRAJC, Mateja, 2018, Interval cancers after negative immunochemical test compared to screen and non-respondersʼ detected cancers in Slovenian colorectal cancer screening programme. Radiology and oncology [online]. 2018. Vol. 52, no. 4, p. 413–421, v. [Accessed 6 April 2025]. DOI 10.2478/raon-2018-0025. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19078
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:presejalni programi, rak debelega črevesa, fekalni imunokemični testi, kolorektalni rak


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