| Title: | Biocompatible polyelectrolyte multilayers with copper oxide and zinc oxide nanoparticles for inhibiting bacterial growth |
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| Authors: | ID Matijaković Mlinarić, Nives (Author)
ID Altenried, Stefanie (Author)
ID Selmani, Atiđa (Author)
ID Nikolić, Juraj (Author)
ID Učakar, Aleksander (Author)
ID Zore, Anamarija (Author)
ID Abram, Anže (Author)
ID Lehner, Sandro (Author)
ID Sever Škapin, Andrijana (Author)
ID Kušter, Monika (Author)
ID Roblegg, Eva (Author)
ID Kovačević, Davor (Author)
ID Ren, Qun (Author)
ID Bohinc, Klemen (Author) |
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| Files: |  URL - Source URL, visit https://pubs.acs.org/doi/10.1021/acsanm.4c00981
 PDF - Presentation file, download (6,90 MB)
MD5: 4EEA953C3C6D66A4B3681F14D877864A
PDF - Supplement, download (930,32 KB)
MD5: AB525F563B3F21350ADFB18E6015F7FB
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  ZAG - Slovenian National Building and Civil Engineering Institute
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| Abstract: | The prevalence of bacterial infections presents a significant challenge in the medical field, demanding effective strategies to impede bacterial adhesion and growth on various surfaces. The conducted study investigates the efficacy of polyelectrolyte multilayers─comprising poly(allylamine hydrochloride) (PAH) and alginate (ALG)─embedded with zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) to inhibit bacterial adhesion on stainless-steel surfaces. Surface characterization involved zeta potential, contact angle, and roughness assessments. The effect of NP composition, size, and morphology in conjunction with polycation or polyanion terminating multilayers was evaluated against planktonic and surface-adhered Escherichia coli (E. coli) cells. Surfaces with the positively charged PAH-terminating multilayer displayed higher water contact angles (≈ 63°) than the negatively charged ALG-terminating multilayers (≈ 45°). Multilayers containing ZnO NPs showed a significant inhibition of planktonic E. coli growth, >99%. Moreover, complete growth inhibition of surface-adhered E. coli was achieved for multilayers containing both ZnO and CuO. Due to their larger specific surface area, rod-like ZnO NPs displayed higher antibacterial activity. The samples with ALG as the terminating layer showed more substantial antibacterial properties than samples with PAH as the terminating layer. Biocompatibility tests on immortalized human keratinocyte cells revealed good compatibility with multilayers incorporating NPs. In summary, this study underscores the potential of ZnO and CuO NPs within PAH/ALG multilayers for antibacterial applications without compromising their cytocompatibility. |
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| Keywords: | polyelectrolyte multilayers, alginate, poly(allylamine hydrochloride), CuO, ZnO, nanoparticles, Escherichia coli |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 16.05.2024 |
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| Publisher: | American Chemical Society |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 12207-13820 |
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| Numbering: | Vol. 7, issue 11 |
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| PID: | 20.500.12556/DiRROS-19053  |
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| UDC: | 577:579 |
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| ISSN on article: | 2574-0970 |
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| DOI: | 10.1021/acsanm.4c00981 |
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| COBISS.SI-ID: | 195799811 |
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| Copyright: | © 2024 The Authors. |
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| Publication date in DiRROS: | 06.06.2024 |
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| Views: | 431 |
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| Downloads: | 346 |
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