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Naslov:Prognostic significance of uPA/PAI-1 level, HER2 status, and traditional histologic factors for survival in node-negative breast cancer patients
Avtorji:ID Fokter Dovnik, Nina (Avtor)
ID Takač, Iztok (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.degruyter.com/downloadpdf/j/raon.2017.51.issue-1/raon-2016-0024/raon-2016-0024.pdf
 
.pdf PDF - Predstavitvena datoteka, prenos (550,67 KB)
MD5: 484582031052E1D89E4E615FFF70B263
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. The association of HER2 status with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) levels raises the question whether uPA/PAI-1 level carries additional clinically relevant prognostic information independently from HER2 status. The aim of our study was to compare the prognostic value of uPA/PAI-1 level, HER2 status, and traditional prognostic factors for survival in node-negative breast cancer patients. Patients and methods. A retrospective analysis of 858 node-negative breast cancer patients treated in Maribor University Clinical Center, Slovenia, in the years 2000-2009 was performed. Data were obtained from patient medical records. The median follow-up time was 100 months. Univariate and multivariate analyses of disease-free (DFS) and overall survival (OS) were performed using the Cox regression and the Cox proportional hazards model. Results. In univariate analysis, age, tumor size, grade, lymphovascular invasion, HER2 status and UPA/PAI-1 level were associated with DFS, and age, tumor size, grade, and uPA/PAI-1 level were associated with OS. In the multivariate model, the most important determinants of DFS were age, estrogen receptor status and uPA/PAI-1 level, and the most important factors for OS were patient age and tumor grade. The HR for death from any cause in the multivariate model was 1.98 (95% CI 0.83-4.76) for patients with high uPA and/or PAI-1 compared to patients with both values low. Conclusions. uPA/PAI-1 level clearly carries an independent prognostic value regardless of HER2 status in node-negative breast cancer and could be used in addition to HER2 and other markers to guide clinical decisions in this setting.
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.2017
Založnik:Association of Radiology and Oncology
Leto izida:2017
Št. strani:str. 65-73, VI
Številčenje:Vol. 51, no. 1
Izvor:Ljubljana
PID:20.500.12556/DiRROS-19025 Novo okno
UDK:618.19-006
ISSN pri članku:1318-2099
DOI:10.1515/raon-2016-0024 Novo okno
COBISS.SI-ID:5717567 Novo okno
Avtorske pravice:by Authors
Datum objave v DiRROS:03.06.2024
Število ogledov:497
Število prenosov:268
Metapodatki:XML DC-XML DC-RDF
:
FOKTER DOVNIK, Nina in TAKAČ, Iztok, 2017, Prognostic significance of uPA/PAI-1 level, HER2 status, and traditional histologic factors for survival in node-negative breast cancer patients. Radiology and oncology [na spletu]. 2017. Vol. 51, no. 1, p. 65–73, vi. [Dostopano 14 april 2025]. DOI 10.1515/raon-2016-0024. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=19025
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:dojka, rak (medicina), adjuvantno sistemsko zdravljenje, urokinazni aktivator plazminogena, plazminogen aktivator, inhibitor 1, HER2 status, prognoza


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