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Naslov:Excellent outcomes after radiotherapy alone for malignant spinal cord compression from myeloma
Avtorji:ID Rades, Dirk (Avtor)
ID Conde-Moreno, Antonio J. (Avtor)
ID Cacicedo, Jon (Avtor)
ID Šegedin, Barbara (Avtor)
ID Rudat, Volker (Avtor)
ID Schild, Steven E. (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://www.degruyter.com/downloadpdf/j/raon.2016.50.issue-3/raon-2016-0029/raon-2016-0029.xml
 
.pdf PDF - Predstavitvena datoteka, prenos (585,22 KB)
MD5: 1C54326395878B719547C59CBE97CA4A
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Uncertainty exists whether patients with spinal cord compression (SCC) from a highly radiosensitive tumor require decompressive spinal surgery in addition to radiotherapy (RT). This study addressed the question by evaluating patients receiving RT alone for SCC from myeloma. Patients and methods. Data of 238 patients were retrospectively analyzed for response to RT and local control of SCC. In addition, the effect of RT on motor function (improvement, no further progression, deterioration) was evaluated. Overall response was defined as improvement or no further progression of motor dysfunction. Prior to RT, patients were presented to a neurosurgeon for evaluation whether upfront decompressive surgery was indicated (e.g. vertebral fracture or unstable spine). Results. In the entire cohort, the overall response rate was 97% (53% improvement plus 44% no further progression). Following RT, 88% of the patients were able to walk. Of the 69 non-ambulatory patients 44 patients (64%) regained the ability to walk. Local control rates at 1, 2 and 3 years were 93%, 82% and 82%, respectively. A trend towards better local control was observed for patients who were ambulatory before starting RT (p = 0.08) and those with a more favorable performance status (p = 0.07). Conclusions. RT alone provided excellent response rates, functional outcomes and local control in patients with SCC from myeloma. These results should be confirmed in a prospective randomized trial.
Ključne besede:myeloma, spinal cord compression, radiotherapy
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.09.2016
Založnik:Association of Radiology and Oncology
Leto izida:2016
Št. strani:str. 337-340, VII
Številčenje:Vol. 50, no. 3
Izvor:Ljubljana
PID:20.500.12556/DiRROS-18869 Novo okno
UDK:616.832-006-08:615.849
ISSN pri članku:1318-2099
DOI:10.1515/raon-2016-0029 Novo okno
COBISS.SI-ID:2489211 Novo okno
Avtorske pravice:by Authors
Datum objave v DiRROS:30.04.2024
Število ogledov:650
Število prenosov:359
Metapodatki:XML DC-XML DC-RDF
:
RADES, Dirk, CONDE-MORENO, Antonio J., CACICEDO, Jon, ŠEGEDIN, Barbara, RUDAT, Volker in SCHILD, Steven E., 2016, Excellent outcomes after radiotherapy alone for malignant spinal cord compression from myeloma. Radiology and oncology [na spletu]. 2016. Vol. 50, no. 3, p. 337–340, vii. [Dostopano 12 april 2025]. DOI 10.1515/raon-2016-0029. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=18869
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:mielom, hrbtenjača, radioterapija


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