Digital repository of Slovenian research organisations

Show document
A+ | A- | Help | SLO | ENG

Title:Excellent outcomes after radiotherapy alone for malignant spinal cord compression from myeloma
Authors:ID Rades, Dirk (Author)
ID Conde-Moreno, Antonio J. (Author)
ID Cacicedo, Jon (Author)
ID Šegedin, Barbara (Author)
ID Rudat, Volker (Author)
ID Schild, Steven E. (Author)
Files:URL URL - Source URL, visit https://www.degruyter.com/downloadpdf/j/raon.2016.50.issue-3/raon-2016-0029/raon-2016-0029.xml
 
.pdf PDF - Presentation file, download (585,22 KB)
MD5: 1C54326395878B719547C59CBE97CA4A
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Uncertainty exists whether patients with spinal cord compression (SCC) from a highly radiosensitive tumor require decompressive spinal surgery in addition to radiotherapy (RT). This study addressed the question by evaluating patients receiving RT alone for SCC from myeloma. Patients and methods. Data of 238 patients were retrospectively analyzed for response to RT and local control of SCC. In addition, the effect of RT on motor function (improvement, no further progression, deterioration) was evaluated. Overall response was defined as improvement or no further progression of motor dysfunction. Prior to RT, patients were presented to a neurosurgeon for evaluation whether upfront decompressive surgery was indicated (e.g. vertebral fracture or unstable spine). Results. In the entire cohort, the overall response rate was 97% (53% improvement plus 44% no further progression). Following RT, 88% of the patients were able to walk. Of the 69 non-ambulatory patients 44 patients (64%) regained the ability to walk. Local control rates at 1, 2 and 3 years were 93%, 82% and 82%, respectively. A trend towards better local control was observed for patients who were ambulatory before starting RT (p = 0.08) and those with a more favorable performance status (p = 0.07). Conclusions. RT alone provided excellent response rates, functional outcomes and local control in patients with SCC from myeloma. These results should be confirmed in a prospective randomized trial.
Keywords:myeloma, spinal cord compression, radiotherapy
Publication status:Published
Publication version:Version of Record
Publication date:01.09.2016
Publisher:Association of Radiology and Oncology
Year of publishing:2016
Number of pages:str. 337-340, VII
Numbering:Vol. 50, no. 3
Source:Ljubljana
PID:20.500.12556/DiRROS-18869 New window
UDC:616.832-006-08:615.849
ISSN on article:1318-2099
DOI:10.1515/raon-2016-0029 New window
COBISS.SI-ID:2489211 New window
Copyright:by Authors
Publication date in DiRROS:30.04.2024
Views:647
Downloads:356
Metadata:XML DC-XML DC-RDF
:
RADES, Dirk, CONDE-MORENO, Antonio J., CACICEDO, Jon, ŠEGEDIN, Barbara, RUDAT, Volker and SCHILD, Steven E., 2016, Excellent outcomes after radiotherapy alone for malignant spinal cord compression from myeloma. Radiology and oncology [online]. 2016. Vol. 50, no. 3, p. 337–340, vii. [Accessed 7 April 2025]. DOI 10.1515/raon-2016-0029. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=18869
Copy citation
  
Share:Bookmark and Share


Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:mielom, hrbtenjača, radioterapija


Back