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Naslov:Prognostic value of some tumor markers in unresectable stage IV oropharyngeal carcinoma patients treated with concomitant radiochemotherapy
Avtorji:ID Šoba, Erika (Avtor)
ID Budihna, Marjan (Avtor)
ID Šmid, Alojz (Avtor)
ID Gale, Nina (Avtor)
ID Lešničar, Hotimir (Avtor)
ID Zakotnik, Branko (Avtor)
ID Strojan, Primož (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (560,05 KB)
MD5: 8E70FF0769382822F55D4A213E267C80
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:The aim of the study was to investigate how the expression of tumor markers p21, p27, p53, cyclin D1, EGFR, Ki-67, and CD31 influenced the outcome of advanced inoperable oropharyngeal carcinoma patients, treated with concomitant radiochemotherapy. Patients and methods. The pretreatment biopsy specimens of 74 consecutive patients with inoperable stage IV oropharyngeal squamous cell carcinoma treated with concomitant radiochemotherapy were in retrospective study processed by immunochemistry for p21, p27, p53, cyclin D1, EGFR, Ki-67, and CD31. Disease-free survival (DFS) was assessed according to the expression of tumor markers. Results. Patients with a high expression of p21 (%10%), p27 (>50%), Ki-67 (>50%), CD31 (>130 vessels/mm2) and low expression of p53 (<10%), cyclin D1 (<10%) and EGFR (<10%) (favorable levels - FL) had better DFS than patients with a low expression of p21 (<10%), p27 (%50%), Ki-67 (%50%), CD31 (<130 vessels/mm2) and high expression of p53 (%10%), cyclin D1 (%10%) and EGFR (%10%) (unfavorable levels - UL). However, statistical significance in survival between FL and UL was achieved only for p27 and cyclin D1. DFS significantly decreased with an increasing number of markers with an unfavorable level per tumor (1%4 vs. 5%7) (78% vs. 32%, respectively; p = 0.004). The number of markers per tumor with UL of expression retained prognostic significance also in multivariate analysis. Conclusions. Statistical significance in survival between FL and UL emerged only for p27 and cyclin D1. The number of markers per tumor with UL of expression was an independent prognostic factor for an adverse outcome .
Ključne besede:oropharynx, radiochemotherapy, tumor markers
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.12.2015
Založnik:Association of Radiology and Oncology
Leto izida:2015
Št. strani:str. 365-370, IV
Številčenje:Vol. 49, no. 4
Izvor:Ljubljana
PID:20.500.12556/DiRROS-18791 Novo okno
UDK:616.21-006
ISSN pri članku:1318-2099
DOI:10.2478/raon-2014-0048 Novo okno
COBISS.SI-ID:2215035 Novo okno
Avtorske pravice:by Authors
Datum objave v DiRROS:22.04.2024
Število ogledov:653
Število prenosov:240
Metapodatki:XML DC-XML DC-RDF
:
ŠOBA, Erika, BUDIHNA, Marjan, ŠMID, Alojz, GALE, Nina, LEŠNIČAR, Hotimir, ZAKOTNIK, Branko in STROJAN, Primož, 2015, Prognostic value of some tumor markers in unresectable stage IV oropharyngeal carcinoma patients treated with concomitant radiochemotherapy. Radiology and oncology [na spletu]. 2015. Vol. 49, no. 4, p. 365–370, iv. [Dostopano 15 april 2025]. DOI 10.2478/raon-2014-0048. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=18791
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:ustno žrelo, tumorji, radiokemoterapija, tumorski označevalci


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