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Title:Prognostic value of some tumor markers in unresectable stage IV oropharyngeal carcinoma patients treated with concomitant radiochemotherapy
Authors:ID Šoba, Erika (Author)
ID Budihna, Marjan (Author)
ID Šmid, Alojz (Author)
ID Gale, Nina (Author)
ID Lešničar, Hotimir (Author)
ID Zakotnik, Branko (Author)
ID Strojan, Primož (Author)
Files:.pdf PDF - Presentation file, download (560,05 KB)
MD5: 8E70FF0769382822F55D4A213E267C80
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:The aim of the study was to investigate how the expression of tumor markers p21, p27, p53, cyclin D1, EGFR, Ki-67, and CD31 influenced the outcome of advanced inoperable oropharyngeal carcinoma patients, treated with concomitant radiochemotherapy. Patients and methods. The pretreatment biopsy specimens of 74 consecutive patients with inoperable stage IV oropharyngeal squamous cell carcinoma treated with concomitant radiochemotherapy were in retrospective study processed by immunochemistry for p21, p27, p53, cyclin D1, EGFR, Ki-67, and CD31. Disease-free survival (DFS) was assessed according to the expression of tumor markers. Results. Patients with a high expression of p21 (%10%), p27 (>50%), Ki-67 (>50%), CD31 (>130 vessels/mm2) and low expression of p53 (<10%), cyclin D1 (<10%) and EGFR (<10%) (favorable levels - FL) had better DFS than patients with a low expression of p21 (<10%), p27 (%50%), Ki-67 (%50%), CD31 (<130 vessels/mm2) and high expression of p53 (%10%), cyclin D1 (%10%) and EGFR (%10%) (unfavorable levels - UL). However, statistical significance in survival between FL and UL was achieved only for p27 and cyclin D1. DFS significantly decreased with an increasing number of markers with an unfavorable level per tumor (1%4 vs. 5%7) (78% vs. 32%, respectively; p = 0.004). The number of markers per tumor with UL of expression retained prognostic significance also in multivariate analysis. Conclusions. Statistical significance in survival between FL and UL emerged only for p27 and cyclin D1. The number of markers per tumor with UL of expression was an independent prognostic factor for an adverse outcome .
Keywords:oropharynx, radiochemotherapy, tumor markers
Publication status:Published
Publication version:Version of Record
Publication date:01.12.2015
Publisher:Association of Radiology and Oncology
Year of publishing:2015
Number of pages:str. 365-370, IV
Numbering:Vol. 49, no. 4
Source:Ljubljana
PID:20.500.12556/DiRROS-18791 New window
UDC:616.21-006
ISSN on article:1318-2099
DOI:10.2478/raon-2014-0048 New window
COBISS.SI-ID:2215035 New window
Copyright:by Authors
Publication date in DiRROS:22.04.2024
Views:643
Downloads:239
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:
ŠOBA, Erika, BUDIHNA, Marjan, ŠMID, Alojz, GALE, Nina, LEŠNIČAR, Hotimir, ZAKOTNIK, Branko and STROJAN, Primož, 2015, Prognostic value of some tumor markers in unresectable stage IV oropharyngeal carcinoma patients treated with concomitant radiochemotherapy. Radiology and oncology [online]. 2015. Vol. 49, no. 4, p. 365–370, iv. [Accessed 7 April 2025]. DOI 10.2478/raon-2014-0048. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=18791
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:ustno žrelo, tumorji, radiokemoterapija, tumorski označevalci


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