Digitalni repozitorij raziskovalnih organizacij Slovenije

Izpis gradiva
A+ | A- | Pomoč | SLO | ENG

Naslov:A review of the treatment options for skin rash induced by EGFR-targeted therapies : evidence from randomized clinical trials and a meta-analysis
Avtorji:ID Ocvirk, Janja (Avtor)
ID Heeger, Steffen (Avtor)
ID McCloud, Philip (Avtor)
ID Hofheinz, Ralf-Dieter (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (403,77 KB)
MD5: 0579A2948A05A9E6F756D06DDB753C87
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. Agents targeting the epidermal growth factor receptor (EGFR) are amongst the most extensively used of the targeted agents in the therapy of some of the most common solid tumors. Although they avoid many of the classic side effects associated with cytotoxic chemotherapy, they are associated with unpleasant cutaneous toxicities which can affect treatment compliance and impinge on patient quality of life. To date, despite a plethora of consensus recommendations, expert opinions and reviews, there is a paucity of evidence-based guidance for the management of the skin rash that occurs in the treatment of patients receiving EGFR-targeted therapies. Methods. A literature search was conducted as a first step towards investigating not only an evidence-based approach to the management of skin rash, but also with a view to designing future randomized trials. Results. The literature search identified seven randomized trials and a meta-analysis was conducted using the data from four of these trials involving oral antibiotics. The meta-analysis of the data from these four trials suggests that prophylactic antibiotics might reduce the relative risk of severe rash associated with EGFR-targeted agents by 4277%. Vitamin K cream was also identified as having a potential role in the management EGFR-targeted agent induced rash. Conclusions. This review and meta-analysis clearly identify the need for further randomized studies of the role of oral antibiotics in this setting. The results of the ongoing randomized trials of the topical application of vitamin K cream plus or minus doxycycline and employing prophylactic versus reactive strategies are eagerly awaited.
Ključne besede:acne-like skin rash, cetuximab, erlotinib, gefitinib, panitumumab, vitamin K
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.06.2013
Založnik:Association of Radiology and Oncology
Leto izida:2013
Št. strani:str. 166-175, VI
Številčenje:Vol. 47, no. 2
Izvor:Ljubljana
PID:20.500.12556/DiRROS-18542 Novo okno
UDK:616-006
ISSN pri članku:1318-2099
DOI:10.2478/raon-2013-0014 Novo okno
COBISS.SI-ID:1577851 Novo okno
Avtorske pravice:by Authors
Datum objave v DiRROS:22.03.2024
Število ogledov:546
Število prenosov:337
Metapodatki:XML DC-XML DC-RDF
:
Kopiraj citat
  
Objavi na:Bookmark and Share


Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.

Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:aknam podobni izpuščaji, antibiotiki, tarčna zdravila


Nazaj