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Title:Angiogenin and vascular endothelial growth factor expression in lungs of lung cancer patients
Authors:ID Rozman, Aleš (Author)
ID Šilar, Mira (Author)
ID Košnik, Mitja (Author)
Files:.pdf PDF - Presentation file, download (467,61 KB)
MD5: 50A16E258D946590730C254121AE46C2
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background. Lung cancer is the leading cause of cancer deaths. Angiogenesis iscrucial process in cancer growth and progression. This prospective study evaluated expression of two central regulatory molecules: angiogenin and vascular endothelial growth factor (VEGF) in patients with lung cancer. Patients and methods. Clinical data, blood samples and broncho-alveolar lavage(BAL) from 23 patients with primary lung carcinoma were collected. BAL fluid was taken from part of the lung with malignancy, and from corresponding healthy side of the lung. VEGF and angiogenin concentrations were analysed by an enzyme-linked immunosorbent assay. Dilution of bronchial secretions in the BAL fluid was calculated from urea concentration ratio between serum and BAL fluid. Results. We found no statistical correlation between angiogenin concentrations in serum and in bronchial secretions from both parts of the lung. VEGF concentrations were greater in bronchial secretions in the affectedside of the lung than on healthy side. Both concentrations were greater than serum VEGF concentration. VEGF concentration in serum was in positive correlation with tumour size (p = 0,003) and with metastatic stage ofdisease (p = 0,041). There was correlation between VEGF and angiogenin concentrations in bronchial secretions from healthy side of the lung and between VEGF and angiogenin concentrations in bronchial secretions from part of the lung with malignancy. Conclusion. Angiogenin and VEGF concentrations insystemic, background and local samples of patients with lung cancer are affected by different mechanisms. Pro-angiogenic activity of lung cancer has an important influence on the levels of angiogenin and VEGF.
Publication status:Published
Publication version:Version of Record
Publication date:01.12.2012
Publisher:Association of Radiology and Oncology
Year of publishing:2012
Number of pages:str. 354-359, VII
Numbering:Vol. 46, no. 4
Source:Ljubljana
PID:20.500.12556/DiRROS-18534 New window
UDC:616-006
ISSN on article:1318-2099
COBISS.SI-ID:30200537 New window
Copyright:by Authors
Note:BSDOCID165935;
Publication date in DiRROS:22.03.2024
Views:787
Downloads:170
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ROZMAN, Aleš, ŠILAR, Mira and KOŠNIK, Mitja, 2012, Angiogenin and vascular endothelial growth factor expression in lungs of lung cancer patients. Radiology and oncology [online]. 2012. Vol. 46, no. 4, p. 354–359, vii. [Accessed 7 April 2025]. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=18534
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

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