Digitalni repozitorij raziskovalnih organizacij Slovenije

Izpis gradiva
A+ | A- | Pomoč | SLO | ENG

Naslov:Long term outcome after combined modality treatment for anal cancer
Avtorji:ID Oblak, Irena (Avtor)
ID Petrič, Primož (Avtor)
ID Anderluh, Franc (Avtor)
ID Velenik, Vaneja (Avtor)
ID Fras, Albert-Peter (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (533,54 KB)
MD5: DC2C0A181B66244AA5A5AA53D9DD8D7A
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. The aim of the retrospective study was to evaluate the effectiveness and toxicity of radiochemotherapy in patients with squamous cellcarcinoma of the anal canal treated at a single institution. Patients and methods. Between 1/2003 and 9/2010, 84 patients were treated with radical radiochemotherapy at the Institute of Oncology Ljubljana, Slovenia. The treatment consisted of 3-dimensional conformal external beam radiotherapy with concurrent chemotherapy (5-fluorouracil and mytomycin C), followed by brachytherapy or external beam boost. The toxicity of therapy and its effectiveness were assessed. Results. The treatment was completed according tothe protocol in 79.8% of patients. The median follow-up time of 55 survivors was 53 months (range: 16-105 months). The 5-year locoregional control(LRC), disease-free survival (DFS), disease-specific survival (DSS), overall survival (OS) and colostomy-free survival (CFS) rates were 71%, 68%, 81%, 67% and 85%, respectively. No treatment-related mortality was observed. The most frequent acute side-effect of the treatment was radiodermatitis (grade 3-4 in 58.2% of patients). LENT-SOMA grade 3-4 late radiation side effects were observed in 15 (18%) patients. In patients with brachytherapy boost a trend of less late side effects was observed compared to patients with external beam boost (P=0.066). On multivariate analysis, complete clinicaldisease response was identified as an independent prognostic factor for LRC, DFS and DSS, the salvage surgery for LRC and DFS, whereas Hb below 120 g/l retained its independent prognostic value for OS. Conclusions. Radiochemotherapy provides an excellent disease control and the survival with preserving anal sphincter function in majority of patients. Surgical salvage with abdominoperineal resection for persistent or recurrent disease has curative potential.
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.06.2012
Založnik:Association of Radiology and Oncology
Leto izida:2012
Št. strani:str. 145-152, IV
Številčenje:Vol. 46, no. 2
Izvor:Ljubljana
PID:20.500.12556/DiRROS-18492 Novo okno
UDK:616.35-006.6-08
ISSN pri članku:1318-2099
DOI:10.2478/v10019-012-0022-2 Novo okno
COBISS.SI-ID:1290619 Novo okno
Avtorske pravice:by Authors
Opomba:Soavtorji: Primož Petrič, Franc Anderluh, Vaneja Velenik, Peter Albert Fras;
Datum objave v DiRROS:21.03.2024
Število ogledov:530
Število prenosov:176
Metapodatki:XML DC-XML DC-RDF
:
Kopiraj citat
  
Objavi na:Bookmark and Share


Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.

Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Naslov:Dolgoročni rezultati kombiniranega zdravljenja raka analnega kanala


Nazaj