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Title:Triple negative breast cancer : prognostic factors and survival
Authors:ID Ovčariček, Tanja (Author)
ID Frković-Grazio, Snježana (Author)
ID Matos, Erika (Author)
ID Možina, Barbara (Author)
ID Borštnar, Simona (Author)
Files:.pdf PDF - Presentation file, download (536,99 KB)
MD5: 8CC7DAE81E0E53949985C2D9D0733182
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background. Triple negative breast cancer (TNBC) is defined by a lack of expression of both estrogen (ER) and progesteron(PgR) receptors as well as human epidermal growth factor receptor 2 (HER2). Our retrospective analysis addressed prognostic factors for short- and long-term outcomes of patients (pts) with TNBC pts treated in routine clinical practice. Patient and methods.Our retrospective study included 269 TNBC treated at Institute of Oncology Ljubljana between March 2000 and December 2006. The collected data included patientsć, tumoursć and treatmentsć characteristics. The survival analyses were performed using the Kaplan-Meier method. The Cox proportional hazard model was used in the multivariate analysis. Results. The median age ofour patients was 55.3 yrs (23-88.5) and the median follow-up was 5.9 yrs (0.3-9.6). Six (2%) pts experienced local only, 79 (92%) pts distal recurrenceand 66 (24%) died. The predominant localisation of the first relapsewas in visceral organs (70.4%). The 5-year disease-free survival (DFS) for the entire group was 68.2% and the 5-year overall survival (OS) was 74.5%.We found a pattern of high recurrence rate in the first 3 years following the diagnosis and a clear decline in recurrence rate over the next 3years. In the univariate analysis age, nodal status, size and lymphovascular invasion (LVI) were found to have a significant impact on DFS as well as on OS. In the multivariate analysis only age (HR=1.79; 95%CI=1.14-2.82; p=0.012) and nodal status (HR=2.71; 95%CI=1.64-4.46; p<0.001) retained their independent prognostic value for DFS and for OS only the nodal status (HR=2.96; 95%CI=1.51-5.82; p=0.002). (Abstract truncated at 2000 characters)
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2011
Publisher:Association of Radiology and Oncology
Year of publishing:2011
Number of pages:str. 46-52
Numbering:Vol. 45, no. 1
Source:Ljubljana
PID:20.500.12556/DiRROS-18471 New window
UDC:618.19-006.6
ISSN on article:1318-2099
DOI:10.2478/v10019-010-0054.4 New window
COBISS.SI-ID:28183001 New window
Copyright:by Authors
Note:BSDOCID156656;
Publication date in DiRROS:19.03.2024
Views:770
Downloads:223
Metadata:XML DC-XML DC-RDF
:
OVČARIČEK, Tanja, FRKOVIĆ-GRAZIO, Snježana, MATOS, Erika, MOŽINA, Barbara and BORŠTNAR, Simona, 2011, Triple negative breast cancer : prognostic factors and survival. Radiology and oncology [online]. 2011. Vol. 45, no. 1, p. 46–52. [Accessed 27 April 2025]. DOI 10.2478/v10019-010-0054.4. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=18471
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

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