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Title: Image cytometric nuclear texture features in inoperable head and neck cancer : a pilot study Authors: ID Strojan Fležar, Margareta (Author) ID Lavrenčak, Jaka (Author) ID Žganec, Mario (Author) ID Strojan, Primož (Author) Files: PDF - Presentation file, download (427,02 KB) MD5: 6900554E107E8CC4AD3EE352FDC860AC   Language: English Typology: 1.01 - Original Scientific Article Organization: OI - Institute of Oncology Abstract: Background. Image cytometry can measure numerous nuclear features which could be considered a surrogate end-point marker of molecular genetic changes in a nucleus. The aim of the study was to analyze image cytometric nuclear featuresin paired samples of primary tumor and neck metastasis in patients with inoperable carcinoma of the head and neck. Materials and methods. Image cytometric analysis of cell suspensions prepared from primary tumor tissue andfine needle aspiration biopsy cell samples of neck metastases from 21 patients treated with concomitant radiochemotherapy was performed. Nuclear features were correlated with clinical characteristics and response to therapy. Results. Manifestation of distant metastases and new primaries was associated (p<0.05) with several chromatin characteristics from primary tumor cells, whereas the origin of index cancer and disease response in the neck wasrelated to those in the cells from metastases. Many nuclear features of primary tumors and metastases correlated with the TNM stage. Conclusions. A specific pattern of correlation between well-established prognostic indicatorsand nuclear features of samples from primary tumors and those from neck metastases was observed. Image cytometric nuclear features represent a promising candidate marker for recognition of biologically different tumor subgroups. Publication status: Published Publication version: Version of Record Publication date: 01.01.2011 Publisher: Association of Radiology and Oncology Year of publishing: 2011 Number of pages: str. 40-45 Numbering: Vol. 45, no. 1 Source: Ljubljana PID: 20.500.12556/DiRROS-18469  UDC: 616-006.6:611.91/.93 ISSN on article: 1318-2099 DOI: 10.2478/v10019-011-0002-y  COBISS.SI-ID: 28182745  Copyright: by Authors Note: BSDOCID156653; Publication date in DiRROS: 19.03.2024 Views: 407 Downloads: 122 Metadata:    Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Radiology and oncology
Shortened title:	Radiol. oncol.
Publisher:	Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:	1318-2099
COBISS.SI-ID:	32649472

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