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Title:Postoperative radiochemotherapy for gastric adenocarcinoma : long term results
Authors:ID Oblak, Irena (Author)
ID Anderluh, Franc (Author)
ID Velenik, Vaneja (Author)
Files:.pdf PDF - Presentation file, download (94,49 KB)
MD5: 2F9A0BC05850683EB21AE0814A1A5908
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background. To analyze the efficacy of postoperative radiochemotherapy with 5-florouracil (5-FU) and leucovorin (LV) applied in the patients with gastric carcinoma treated in a single institution. Patients and methods. Between 2001 and 2004, 123 patients with resected gastric adenocarcinoma were treated with postoperative concomitant radiochemotherapy with 5-FU and LV. The adjuvant treatment consisted of five cycles of chemotherapy with 5-FU (425mg/m2 IV) andLV (20 mg/m2 IV) and concomitant radiotherapy with the total dose of 45 Gy.Results. The treatment was completed according to the protocol in 82% of patients. The frequency and severity of early toxic effects induced by radiochemotherapy were manageable. Median follow-up time of 56 survivors was 64.5 months (range: 51.7-96.4 months). The 5-year locoregional control (LRC), diseasefree survival (DFS), disease-specific survival (DSS) and overall survival (OS) were 81%, 48.3%, 50.4%, and 48.4%, respectively. The multivariate analysis showed that the tumor involvement of cardia and low intensity of chemotherapy were independent adverse prognostic factors for DSS and OS. More advanced pT-stage and tumors with diffuse growth type according to Lauren were identified as negative independent prognostic factor for OS. They were also on the threshold of statistical significance for DSS. Conclusions. Postoperative radiochemotherapy for gastric carcinoma has acceptable toxicity, and is effective particularly in regard to LRC. High incidence of distant metastases calls for more effective systemic regimens.
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2009
Publisher:Association of Radiology and Oncology
Year of publishing:2009
Number of pages:str. 274-281
Numbering:Letn. 43, št. 4
Source:Ljubljana
PID:20.500.12556/DiRROS-18373 New window
UDC:616-006
ISSN on article:1318-2099
COBISS.SI-ID:26682073 New window
Copyright:by Authors
Note:BSDOCID149803;
Publication date in DiRROS:08.03.2024
Views:616
Downloads:135
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OBLAK, Irena, ANDERLUH, Franc and VELENIK, Vaneja, 2009, Postoperative radiochemotherapy for gastric adenocarcinoma : long term results. Radiology and oncology [online]. 2009. Vol. 43, no. 4, p. 274–281. [Accessed 2 April 2025]. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=18373
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Title:Postoperativna radiokemoterapija pri bolnikih z rakom želodca


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