| Title: | The role of cyclooxygenase-2 in the malignant tissue and possible applicability of cyclooxygenase-2 inhibitors in the therapy of cancer |
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| Authors: | ID Legan, Mateja (Author) |
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| Files: |  PDF - Presentation file, download (205,37 KB)
MD5: D29F325E25EC16D5D15056F9C1790F95
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Cyclooxygenase-2 (COX 2), an inducible prostaglandin (PG) synthase, is elevated in many types of malignant and pre-malignant tissues. This enzyme is localized in neoplastic (epithelial) cells, microvascular endothelial cells, and stromal fibroblasts. Through the released PG it enhances carcinogenesis with increasing angiogenesis, inhibiting apoptosis, activating matrix metalloproteinases, suppressing of cell mediated antitumor immune response andprotection against damage by cytotoxic agents. Evidences from in vitro studies, studies on animal models as well as first clinical outcomes suggest that the inhibition of COX 2 may suppress carcinogenesis by affecting a numberof pathways: inhibiting angiogenesis, invasiveness of tumors and promoting apoptosis. References forecast that COX 2 inhibitors, mostly COX 2 selective inhibitors, may get a role in the therapy of cancer as an adjuvant therapy or as an co-chemotherapeutic agent. The purpose of the present articleis to summarize the most important facts about the role of COX 2 in themalignant tissue and discuss possible ways for potential therapeutic place of COX 2 inhibitors in clinical practice. |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2003 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2003 |
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| Number of pages: | str. 187-194 |
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| Numbering: | Letn. 37, št. 3 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-18109-3900721c-c6b4-8b29-16e1-303f161c6fbc  |
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| UDC: | 616-006 |
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| ISSN on article: | 1318-2099 |
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| COBISS.SI-ID: | 17000153 |
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| Copyright: | by Authors |
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| Note: | BSDOCID101592;
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| Publication date in DiRROS: | 06.02.2024 |
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| Views: | 435 |
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| Downloads: | 97 |
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| Metadata: |    |
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