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Naslov:Influence of hydralazine on interstitial fluid pressure in experimental tumors - a preliminary study : Vpliv hydralazina na tlak medcelične tekočine v poskusnih tumorjih
Avtorji:ID Podobnik, Blaž (Avtor)
ID Miklavčič, Damijan (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (497,71 KB)
MD5: A40F940206D49FF8D73B708C35F35D08
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo OI - Onkološki inštitut Ljubljana
Povzetek:Background. Interstitial fluid pressure (IFP) has been recognised as the most important obstacle in macromolecular drug delivery to solid tumors. Our interest was to reduce differentialy tumor IFP with respect to IFP in surrounding and normal tissues in order to increase drug delivery to tumors aswell to increase tumor blood flow and potentialy tumor tissue oxygenation. In this preliminary study we used hydralazine, a longacting arterial vasodilator. Materials and methods. Measurements of interstitial fluid pressure were performed in vivo on CBA mice bearing SAF tumors using wick-in-needle technigue. Altogether eleven measurements were obtained on different animals with tumors of different size. Results. IFP in tumors after hydralazine administration was significantly lower than initial values in corresponding tumors. On average tumor IFP decreased for 33 % from initial value. On the contrary, no change in IFP in normal tissue was observed after hydralazine administration. Also, after injection of physiological saline instead of hydralazine there was no change in IFP neither in tumors nor in muscle. The results of our preliminary study on the effect of hydralazine on IFP in SAF tumor model is in accordance to previously reported studies. The decrease in tumor IFP was only observed in tumors, but not in muscle and surrounding subcutis. Conclusion. Hydralazine is a vasodilator which is capable of decreasing tumor IFP, reproducibly and with favorably long lasting dynamics.
Ključne besede:sarcoma, experimental drug therapy, hydralazine, extracellular space, interstitial fluid pressure, manometry
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.03.2000
Založnik:Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society
Leto izida:2000
Št. strani:str. 59-65
Številčenje:Vol. 34, št. 1
Izvor:Ljubljana
PID:20.500.12556/DiRROS-17937 Novo okno
UDK:616-006
ISSN pri članku:1318-2099
COBISS.SI-ID:1818964 Novo okno
Avtorske pravice:by Authors
Datum objave v DiRROS:23.01.2024
Število ogledov:702
Število prenosov:223
Metapodatki:XML DC-XML DC-RDF
:
PODOBNIK, Blaž in MIKLAVČIČ, Damijan, 2000, Influence of hydralazine on interstitial fluid pressure in experimental tumors - a preliminary study : Vpliv hydralazina na tlak medcelične tekočine v poskusnih tumorjih. Radiology and oncology [na spletu]. 2000. Vol. 34, no. 1, p. 59–65. [Dostopano 12 april 2025]. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=17937
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Gradivo je del revije

Naslov:Radiology and oncology
Skrajšan naslov:Radiol. oncol.
Založnik:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:sarkom, eksperimentalna terapija z vnosom zdravila, hidralazin, medcelični prostor, tlak medcelične tekočine, manometrija


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