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Title:Influence of hydralazine on interstitial fluid pressure in experimental tumors - a preliminary study : Vpliv hydralazina na tlak medcelične tekočine v poskusnih tumorjih
Authors:ID Podobnik, Blaž (Author)
ID Miklavčič, Damijan (Author)
Files:.pdf PDF - Presentation file, download (497,71 KB)
MD5: A40F940206D49FF8D73B708C35F35D08
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background. Interstitial fluid pressure (IFP) has been recognised as the most important obstacle in macromolecular drug delivery to solid tumors. Our interest was to reduce differentialy tumor IFP with respect to IFP in surrounding and normal tissues in order to increase drug delivery to tumors aswell to increase tumor blood flow and potentialy tumor tissue oxygenation. In this preliminary study we used hydralazine, a longacting arterial vasodilator. Materials and methods. Measurements of interstitial fluid pressure were performed in vivo on CBA mice bearing SAF tumors using wick-in-needle technigue. Altogether eleven measurements were obtained on different animals with tumors of different size. Results. IFP in tumors after hydralazine administration was significantly lower than initial values in corresponding tumors. On average tumor IFP decreased for 33 % from initial value. On the contrary, no change in IFP in normal tissue was observed after hydralazine administration. Also, after injection of physiological saline instead of hydralazine there was no change in IFP neither in tumors nor in muscle. The results of our preliminary study on the effect of hydralazine on IFP in SAF tumor model is in accordance to previously reported studies. The decrease in tumor IFP was only observed in tumors, but not in muscle and surrounding subcutis. Conclusion. Hydralazine is a vasodilator which is capable of decreasing tumor IFP, reproducibly and with favorably long lasting dynamics.
Keywords:sarcoma, experimental drug therapy, hydralazine, extracellular space, interstitial fluid pressure, manometry
Publication status:Published
Publication version:Version of Record
Publication date:01.03.2000
Publisher:Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society
Year of publishing:2000
Number of pages:str. 59-65
Numbering:Vol. 34, št. 1
Source:Ljubljana
PID:20.500.12556/DiRROS-17937 New window
UDC:616-006
ISSN on article:1318-2099
COBISS.SI-ID:1818964 New window
Copyright:by Authors
Publication date in DiRROS:23.01.2024
Views:686
Downloads:220
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PODOBNIK, Blaž and MIKLAVČIČ, Damijan, 2000, Influence of hydralazine on interstitial fluid pressure in experimental tumors - a preliminary study : Vpliv hydralazina na tlak medcelične tekočine v poskusnih tumorjih. Radiology and oncology [online]. 2000. Vol. 34, no. 1, p. 59–65. [Accessed 7 April 2025]. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=17937
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:sarkom, eksperimentalna terapija z vnosom zdravila, hidralazin, medcelični prostor, tlak medcelične tekočine, manometrija


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