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Title:Adenocarcinoma skin metastases treated by electrochemotherapy with cisplatin combined with radiation
Authors:ID Serša, Gregor (Author)
ID Čemažar, Maja (Author)
ID Rudolf, Zvonimir (Author)
ID Fras, Albert-Peter (Author)
Files:.pdf PDF - Presentation file, download (410,27 KB)
MD5: 6DB8CC7E57015C2548E7A7222197C838
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background. The aim of this study was to determine the interaction between electrochemotherapy as a means of facilitated cisplatin delivery into the cells and irradiation of adenocarcinoma skin metastases. Case report. A patient with progressive disease presenting skin metastases of tubal dedifferentiated pappilary adenocarcinoma was enrolled in the study. Skin metastases were treated by electrochemotherapy with intratumoral injection of cisplatin. Its antitumor effectiveness was compared to that of combined treatment of irradiation with electrochemotherapy. After a two week observation time, the response to treatment was comparable between the electrochemotherapy and electrochemotherapy combined with irradiation. Both ofthese treatments were more effective than irradiation alone. Furthermore, antitumor effectiveness of the combined electrochemo- and radiotherapy was found to be quicker than that of electrochemotherapy alone. Comment. This study shows that electrochemotherapy with cisplatin is also effective in the treatment of adenocarcinoma skin metastases. Inspite of the short observation time, positive interaction between radiotherapy and electrochemotherapy with cisplatin was found.
Publication status:Published
Publication version:Version of Record
Publication date:01.12.1999
Publisher:Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society
Year of publishing:1999
Number of pages:str. 291-296
Numbering:Letn. 33, št. 4
Source:Ljubljana
PID:20.500.12556/DiRROS-17926 New window
UDC:616-006
ISSN on article:1318-2099
COBISS.SI-ID:11070937 New window
Copyright:by Authors
Note:BSDOCID49520;
Publication date in DiRROS:22.01.2024
Views:516
Downloads:129
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Title:Kombinirano zdravljenje kožnih metastaz adenocarcinoma z elektrokemoterapijo in obsevanjem
Abstract:Izhodišča. Študijo smo opravili z namenom, da bi ugotovili medsebojni vpliv med elektrokemoterapijo, s katero smo pospešili vnos cisplatina v celice, in obsevanjem kožnih metastaz adenokarcinoma. Poročilo o primeru. Študija poroča o bolnici z napredovnajem bolezni in ugotovljenimi kožnimi metastazami tubularnega dediferenciranega papilarnega adenokarcinoma. Kožne metastaze smo zdravili z elektrokemoterapijo in vbrizgavanjem cisplatina v tumor. Učinek zdravljenja smo primerjali z učinkom kombiniranega zdravljenja z obsevanjem inelektrokemoterapijo. Obe metodi sta bili učinkovitejši od zdravljenja samo zobsevanjem. Ugotovili smo tudi, da je kombinirano zdravljenje z elektrokemoterapijo in radioterapijo hitreje učinkovalo na tumor kot zdravljenje samo s kemoterapijo. Zaključek. Študija potrjuje, da je elektrokemoterapija s cisplatinom uspešna tudi pri zdravljenju metastaz kožnega adenokarcinoma. Navzlic kratkemu opazovalnem času smo ugotovili ugodenmedsebojen vpliv radioterapije in elektrokemoterapije s cisplatinom.


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