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Title:Epithermal neutron beam for BNCT at the JSI TRIGA reactor - modelling and experimental verification
Authors:ID Maučec, Marko (Author)
ID Glumac, Bogdan (Author)
ID Rant, Jože (Author)
ID Krištof, Edvard (Author)
Files:.pdf PDF - Presentation file, download (553,76 KB)
MD5: 38F9C793934F777166B7305282545C0D
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:It has been reported that satisfactory thermal/epithermal neutron beams for Boron lVeutron Ćapturc, Therapy (BNCT) could be designed at TRIGA research reactors, which are generally perceived as being safe to install and operate in populated areas. This contribution presents the most recent research activities in this field at the Jožef Stefan Institute TRIGA reactor, where anepithermal neutron beam for BNCT is being developed. Experimental verification of Monte Carlo simulation results proves the quality and wide applicability of the developed 3-D model, particularly of the reactor core andirradiation channels. Due to high attenuation of the epithermal neutron flux (fi epi = 4.1x106 n/cmZs, two orders of magnitude belozu the therapeutic limit) the irradiation facility in the current stage of development is not appropriate for the clinical BNCT treatments. Furthermore, the contribution ofthe 2.5 mm airgap surrounding the facility is unacceptably high, thus makingthe relative gamma dose (Dy/fiepi) almost 60-times higher than therapeutically rcc- ommended. Nevertheless, using gamma shielding of Pb or Biand LiF or Li2C03 (thermal neutron cut-off, the quality of the epithermal neutron beam would be significantly upgraded and hecome appropriate fnr iii vitro studies of boron compound transport in malignant tumour cells or smallerlahoratory animals.
Publication status:Published
Publication version:Version of Record
Publication date:01.03.1999
Publisher:Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society
Year of publishing:1999
Number of pages:str. 69-75
Numbering:Letn. 33, št. 1
Source:Ljubljana
PID:20.500.12556/DiRROS-17915 New window
UDC:616-006
ISSN on article:1318-2099
COBISS.SI-ID:9755353 New window
Copyright:by Authors
Note:BSDOCID43334;
Publication date in DiRROS:22.01.2024
Views:562
Downloads:107
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MAUČEC, Marko, GLUMAC, Bogdan, RANT, Jože and KRIŠTOF, Edvard, 1999, Epithermal neutron beam for BNCT at the JSI TRIGA reactor - modelling and experimental verification. Radiology and oncology [online]. 1999. Vol. 33, no. 1, p. 69–75. [Accessed 7 April 2025]. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=17915
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Title:Epitermični izvor nevtronov za terapijo raka z zajetjem nevtronov v boru na reaktorju TRIGA Instituta Jožef Stefan - modeliranje in eksperimentalna preveritev
Abstract:Zaradi specifičnih lastnosti obratovanja spadajo reaktorji TRIGA med najvarnejše raziskovalne reaktorje. V svetu se jih vedno več uporablja kot izvor termičnih oz. epitermičnih nevtronov v namene terapije raka z zajetjem nevtronov v boru (angl. Boron Neutron Ćapture Therapy). Prispevek prikazuje rezultate Monte Carlo modeliranja, optimizacije ter eksperimentalne verifikacije obsevalne naprave z epitermičnimi nevtroni razvite v radialnem kanalu reaktorja TRIGA na Institutu Jožef Stefan v Ljubljani. Rezultati potrjujejo široko uporabnost razvitega tri-dimenzionalnega modela reaktorja, predvsem sredice in obsevalnih kanalov. Zaradi visoke atenuacije nevtronskega fluksa (fiep = 4.1x106 n/cmZs, kar je dobra dva reda velikosti pod priporočenoterapevtsko mejo) obsevalna naprava v obstoječi izvedbi ni primernaza klinična BNCT obsevanja. Prispevek zračne reže, ki obdaja sistem filtrov dodatno prispeva k visoki specifični dozi gama žarkov in hitrih nevtronov na obsevalnem mestu, ki sta skoraj 60-krat višji od priporočenih vrednosti. Vendar pa bi z minimalno predelavo obsevalne naprave ter uporabo zaščitnega ohišja s Pb (ali Bi) ter LiF (ali Li2CO.3) lahko občutno izboljšalikvaliteto obsevalnega curka kot orodja za "in-vitro" študije transporta bora v malignih celičnih kulturah ali laboratorijskih živalih. *


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