| Naslov: | p53 - the paradigm of tumor-suppresor genes? |
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| Avtorji: | ID Jezeršek Novaković, Barbara (Avtor)
ID Novaković, Srdjan (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (482,88 KB)
MD5: B56FBD7D4FC35C4E0A35A9B62F0CD527
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.02 - Pregledni znanstveni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | p53 is a tumor-suppressor gene the alterations of which are among the most frequent genetic changes detected in human neoplasms. Its product - p53 protein is a component of several biochemical pathways that are central to carcinogenesis: DNA transcription, genomic stability, DNA repair, cell cycle control, and apoptosis. The analysis of the spectrum of p53 mutations and insight into the p53 mediated biochemical pathways of programmed cell death and cell cycle arrest, provide clues to understanding of molecular pathogenesis of cancer of mechanisms related to p53 mediated tumor suppression. The purpose of the resent article is to summarise the most important facts concerning p53 since understanding of the above listed processes might provide the potential molecular targets for the development ofa rational cancer treatment. |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.01.1998 |
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| Založnik: | Slovenian Medical Society - Section of Radiology ; Croatian Medical Association - Croatian Society of Radiology |
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| Leto izida: | 1998 |
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| Št. strani: | str. 373-383 |
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| Številčenje: | Letn. 32, št. 4 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-17895  |
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| UDK: | 616-006 |
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| ISSN pri članku: | 1318-2099 |
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| COBISS.SI-ID: | 8141529 |
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| Avtorske pravice: | by Authors |
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| Opomba: | BSDOCID40575;
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| Datum objave v DiRROS: | 19.01.2024 |
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| Število ogledov: | 176 |
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| Število prenosov: | 47 |
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| Metapodatki: |     |
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