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Title:Ocena rezultatov vakcinacije z dendritičnimi celicami pri zdravljenju raka priljudeh
Authors:ID Nestle, Frank O. (Author)
Files:.pdf PDF - Presentation file, download (288,96 KB)
MD5: DD60BA92AC28CEB698A0FF4C12814A81
 
Language:Slovenian
Typology:1.02 - Review Article
Organization:Logo OI - Institute of Oncology
Abstract:Melanom je imunogeni tumor z znanimi tumorskimi antigeni. Pomemben terapevtskicilj je indukcija specifičnih T limpocitov (CTL) proti melanomu. Dendritične celice (DC) so se v večjih mišjih modelih pokazale kot primerne zaindukcjo specifičnih CTL proti melanomu. Razpravljali bomo o trenutnih rezultatih pri uporabi DC za zdravljenje raka pri ljudeh, kot je pridobivanje in uporaba humanih DC, uporaba nadomestnih helperskih antigenov, različnih metodah za odkrivanje za antigen specifičnih imunskih odzivov. Predstavili bomo tudi nekaj naših kliničnih ugotovitev, ki obravnavajo vakcinacijo bolnikov z melanomom v IV stadiju in razpravljli o vzrokih za neodzivnost na zdravljenje.
Publication status:Published
Publication version:Version of Record
Publication date:01.01.1999
Publisher:Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society
Year of publishing:1999
Number of pages:str. S64-8
Numbering:Letn. 33, suppl. 1
Source:Ljubljana
PID:20.500.12556/DiRROS-17372 New window
UDC:616-006
ISSN on article:1318-2099
COBISS.SI-ID:10734297 New window
Copyright:by Authors
Note:Simpozij o malignem melanomu in kožnem raku; BSDOCID48318;
Publication date in DiRROS:28.11.2023
Views:210
Downloads:52
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:English
Title:Critical issues regarding dendritic cell vaccination for human cancer
Abstract:Melanoma is an immunogenetic tumor with defined tumor antigens. An important therapeutic aim is the induction of anti-melanoma specific cytotoxic T-lymphocytes (CTL). Dendritic cells (DC) as natur's adjuvant have proven to be suitable for the inducation of anti-melanoma specific CTL in several murinemodels. We will discuss curent issues in the use of DC for treatment of human cancer such as the generation and application of human DC, use of surrogate helper antigens, various methods to detect antigen-specific immune response and briefly touch on some of our clinical data relating to vaccination of stage IV melanoma patients. Finally, we will propose reasons for missing response to DC therapy.


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