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Title: Rezultati študije RAPIDO Authors: ID Edhemović, Ibrahim (Author) Files: PDF - Presentation file, download (86,79 KB) MD5: 1A39D397103801B68B62BF3693677F56   Language: Slovenian Typology: 1.08 - Published Scientific Conference Contribution Organization: OI - Institute of Oncology Abstract: 3-letno preživetje brez bolezni pri bolnikih z lokalno napredovalim rakom danke je trenutno približno 50 %. Standardno zdravljenje bolnikov z visokim tveganjem za lokalno in/ali sistemsko ponovitev bolezni vključuje predoperativno radioterapijo po dolgem protokolu (5 tednov) v kombinaciji s kemoterapijo (neoadjuvantna kemoradioterapija). Dokazano je, da neoadjuvantna kemoradioterapija izboljša lokalno kontrolo, vendar ne vpliva na preživetje. Sistemski recidivi ostajajo velik problem pri lokalno napredovalem raku danke. Z namenom zmanjšanja oddaljenih metastaz brez ogrožanja lokoregionalnega nadzora z uporabo radioterapije po kratkem režimu, ki ji sledi kemoterapija in odložena operacija je bila sestavljena in izvedena študija RAPIDO (Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation – RAPIDO). Šlo je za multicentrično, mednarodno študijo faze 3 v kateri je sodelovalo 54 onkoloških centrov med katerimi tudi Onkološki inštitut v Ljubljani. Keywords: rak danke, onkološko zdravljenje, klinične študije Publication status: Published Publication version: Version of Record Place of publishing: Ljubljana Publisher: Onkološki inštitut Year of publishing: 2022 Number of pages: Str. 103-105 PID: 20.500.12556/DiRROS-16068-39708ed5-2d64-47d5-77c6-39fda3c59153  UDC: 616.3 COBISS.SI-ID: 135702019  Copyright: by Author Note: Nasl. z nasl. zaslona; Opis vira z dne 29. 12. 2022; Publication date in DiRROS: 16.01.2023 Views: 838 Downloads: 189 Metadata:    Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a monograph

Title:	Tumorji prebavil : Standardi in perspektive
Editors:	Marko Boc, Tanja Mesti
Place of publishing:	Ljubljana
Publisher:	Onkološki inštitut, Sekcija za internistično onkologijo, Katedra za onkologijo
Year of publishing:	2022
ISBN:	978-961-7029-55-0
COBISS.SI-ID:	133694211

Secondary language

Language:	English
Title:	Results of the RAPIDO study
Abstract:	The 3-year disease-free survival rate for patients with locally advanced rectal cancer is currently approximately 50%. Standard treatment for patients at high risk of local and/or systemic disease recurrence includes preoperative radiotherapy following a long protocol (5 weeks) in combination with chemotherapy (neoadjuvant chemoradiotherapy). Neoadjuvant chemoradiotherapy has been shown to improve local control but not to affect survival. Systemic recurrences remain a major problem in locally advanced rectal cancer. The RAPIDO (Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation - RAPIDO) study was designed and implemented with the aim of reducing distant metastases without jeopardizing locoregional control by using radiotherapy after a short regimen, followed by chemotherapy and delayed surgery. It was a multicenter, international phase 3 study in which 54 oncology centers participated, including the Oncology Institute in Ljubljana.
Keywords:	rectal cancer, the RAPIDO study

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