| Naslov: | Estimating quantitative physiological and morphological tissue parameters of murine tumor models using hyperspectral imaging and optical profilometry |
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| Avtorji: | ID Tomanič, Tadej (Avtor)
ID Rogelj, Luka (Avtor)
ID Stergar, Jošt (Avtor)
ID Markelc, Boštjan (Avtor)
ID Božič, Tim (Avtor)
ID Kranjc Brezar, Simona (Avtor)
ID Serša, Gregor (Avtor)
ID Milanič, Matija (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (3,79 MB)
MD5: 7CBDF3E6134B66F092DDDF5345C99D53
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  IJS - Institut Jožef Stefan
 OI - Onkološki inštitut Ljubljana
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| Povzetek: | Understanding tumors and their micro-environment are essential for successfuland accurate disease diagnosis. Tissuephysiology and morphology are altered intumors compared to healthy tissues, andthere is a need to monitor tumors and their surrounding tissues, includingblood vessels, non-invasively. This preliminary study utilizes a multimodaloptical imaging system combining hyperspectral imaging (HSI) and three-dimensional (3D) optical profilometry (OP) to capture hyperspectral imagesand surface shapes of subcutaneously grown murine tumor models. Hyper-spectral images are corrected with 3D OP data and analyzed using the inverse-adding doubling (IAD) method to extract tissue properties such as melaninvolume fraction and oxygenation. Blood vessels are segmented using theB-COSFIRE algorithm from oxygenation maps. From 3D OP data, tumor vol-umes are calculated and compared to manual measurements using a verniercaliper. Results show that tumors can be distinguished from healthy tissuebased on most extracted tissue parameters (p<0:05). Furthermore, blood oxy-genation is 50% higher within the blood vessels than in the surrounding tissue,and tumor volumes calculated using 3D OP agree within 26% with manualmeasurements using a vernier caliper. Results suggest that combining HSI andOP could provide relevant quantitative information about tumors and improvethe disease diagnosis. |
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| Ključne besede: | medical physics, hyperspectral imaging, diffuse reflectance spectroscopy, blood vessels, tumors |
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| Status publikacije: | V tisku |
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| Verzija publikacije: | Recenzirani rokopis |
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| Založnik: | Wiley |
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| Leto izida: | 2022 |
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| Št. strani: | 28 str. |
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| PID: | 20.500.12556/DiRROS-15462  |
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| UDK: | 616-073 |
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| ISSN pri članku: | 1864-0648 |
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| DOI: | 10.1002/jbio.202200181 |
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| COBISS.SI-ID: | 117950211 |
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| Avtorske pravice: | by Authors |
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| Opomba: | Nasl. z nasl. zaslona;
Soavtorji: Luka Rogelj, Jost Stergar, Bostjan Markelc, Tim Bozic, Simona Kranjc Brezar, Gregor Sersa, Matija Milanic;
Opis vira z dne 10. 8. 2022;
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| Datum objave v DiRROS: | 08.09.2022 |
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| Število ogledov: | 932 |
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| Število prenosov: | 329 |
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| Metapodatki: |    |
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