| Title: | Results of screening in early and advanced thoracic malignancies in the EORTC pan-European SPECTAlung platform |
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| Authors: | ID Morfouace, Marie (Author)
ID Novello, Silvia (Author)
ID Stevovic, A. (Author)
ID Dooms, C. (Author)
ID Janžič, Urška, Klinika Golnik (Author)
ID Berghmans, Thierry (Author)
ID Dziadziuszko, Rafal (Author)
ID Gorlia, T. (Author)
ID Felip, Enriqueta (Author)
ID Besse, Benjamin (Author) |
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| Files: |  PDF - Presentation file, download (4,21 MB)
MD5: 1EA8B2AF52F6B1A6FAEB92C782DFB86A
 URL - Source URL, visit https://www.nature.com/articles/s41598-022-12056-0.pdf
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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| Abstract: | Access to a comprehensive molecular alteration screening is patchy in Europe and quality of the molecular analysis varies. SPECTAlung was created in 2015 as a pan-European screening platform for patients with thoracic malignancies. Here we report the results of almost 4 years of prospective molecular screening of patients with thoracic malignancies, in terms of quality of the program and molecular alterations identified. Patients with thoracic malignancies at any stage of disease were recruited in SPECTAlung, from June 2015 to May 2019, in 7 different countries. Molecular tumour boards were organised monthly to discuss patients' molecular and clinical profile and possible biomarker-driven treatments, including clinical trial options. FFPE material was collected and analysed for 576 patients with diagnosis of pleural, lung, or thymic malignancies. Ultimately, 539 patients were eligible (93.6%) and 528 patients were assessable (91.7%). The turn-around time for report generation and molecular tumour board was 214 days (median). Targetable molecular alterations were observed in almost 20% of cases, but treatment adaptation was low (3% of patients). SPECTAlung showed the feasibility of a pan-European screening platform. One fifth of the patients had a targetable molecular alteration. Some operational issues were discovered and adapted to improve efficiency. |
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| Keywords: | thoracic neoplasms -- Europe, lung neoplasms -- Europe, diagnostic screening programs -- Europe, malignancies, lung cancer |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Place of publishing: | Velika Britanija |
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| Publisher: | Springer Nature |
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| Year of publishing: | 2022 |
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| Number of pages: | str. 1-11 |
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| Numbering: | Vol. 12 |
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| PID: | 20.500.12556/DiRROS-15226  |
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| UDC: | 616-006 |
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| ISSN on article: | 2045-2322 |
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| DOI: | 10.1038/s41598-022-12056-0 |
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| COBISS.SI-ID: | 111571715 |
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| Copyright: | © The Author(s) 2022 |
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| Note: | Nasl. z nasl. zaslona;
Soavtorica iz Slovenije: Urška Janžič;
Opis vira z dne 14. 6. 2022;
Št. članka: 8342; |
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| Publication date in DiRROS: | 24.06.2022 |
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| Views: | 1039 |
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| Downloads: | 741 |
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