| Title: | Real-world experience with capmatinib in MET exon 14-mutated non-small cell lung cancer (RECAP) : a retrospective analysis from an early access program |
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| Authors: | ID Illini, Oliver (Author)
ID Fabikan, Hannah (Author)
ID Swalduz, Aurélie (Author)
ID Vikström, Anders (Author)
ID Krenbek, Dagmar (Author)
ID Schumacher, Michael (Author)
ID Dudnik, Elizabeth (Author)
ID Studnicka, Michael (Author)
ID Öhman, Ronny (Author)
ID Wurm, Robert (Author)
ID Čufer, Tanja, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Mohorčič, Katja, Klinika Golnik (Author)
ID Hochmair, Maximilian J (Author) |
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| Files: |  PDF - Presentation file, download (943,38 KB)
MD5: 7467E1DD43C59C8F03153BE0B26C2277
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 URL - Source URL, visit https://journals.sagepub.com/doi/pdf/10.1177/17588359221103206
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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| Abstract: | Background: Patients with non-small cell lung cancer (NSCLC) presenting with mesenchymal–epithelial transition (MET) exon 14 skipping mutation have an unfavorable prognosis with standard treatments. Capmatinib is a selective MET inhibitor, which showed promising efficacy in this patient population in early trials. Methods: We performed a retrospective, international, multicenter efficacy and safety analysis in patients with NSCLC treated with capmatinib in an early access program between March 2019 and December 2021. Results: Data from 81 patients with advanced MET exon 14 mutated NSCLC treated with capmatinib in first- or later-line therapy were analyzed. Median age was 77years (range, 48–91), 56% were women, 86% had stage IV disease, and 27% had brain metastases. For all patients, the objective response rate (ORR) to capmatinib was 58% (95% CI, 47–69), whereas it was 68% (95% CI, 50–82) in treatment-naïve and 50% (95% CI, 35–65) in pretreated patients. The median progression-free survival was 9.5months (95% CI, 4.7–14.3), whereas it was 10.6months (95% CI, 5.5–15.7) in first-line and 9.1months (95% CI, 3.1–15.1) in pretreated patients. After a median follow-up of 11.0months, the median overall survival was 18.2 months (95% CI, 13.2–23.1). In patients with measurable brain metastases (n=11), the intracranial ORR was 46% (95% CI, 17–77). Capmatinib showed a manageable safety profile. Grade⩾3 treatment-related adverse events included peripheral edema (13%), elevated creatinine (4%), and elevated liver enzymes (3%). Conclusion: In patients with MET exon 14 skipping mutation, capmatinib showed durable systemic and intracranial efficacy and a manageable safety profile. This analysis confirms previously reported phase II data in a real-world setting. |
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| Keywords: | non-small cell lung carcinoma -- drug therapy -- genetics, molecular targeted therapy, real-world data, capmatinib, targeted therapy |
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| Publication status: | In print |
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| Publication version: | Author Accepted Manuscript |
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| Place of publishing: | Velika Britanija |
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| Publisher: | Sage Publications |
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| Year of publishing: | 2022 |
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| Number of pages: | str. 1-22 |
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| Numbering: | Vol. 14 |
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| PID: | 20.500.12556/DiRROS-15225  |
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| UDC: | 616-006 |
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| ISSN on article: | 1758-8359 |
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| DOI: | 10.1177/17588359221103206 |
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| COBISS.SI-ID: | 112187139 |
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| Copyright: | © The Author(s), 2022 |
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| Note: | Nasl. z nasl. zaslona;
Soavtorici iz Slovenije: Katja Mohorčič, Tanja Čufer;
Opis vira z dne 20. 6. 2022;
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| Publication date in DiRROS: | 24.06.2022 |
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| Views: | 1124 |
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| Downloads: | 796 |
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