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Naslov:Dynamic contrast-enhanced MRI in malignant pleural mesothelioma : prediction of outcome based on DCE-MRI measurements in patients undergoing cytotoxic chemotherapy
Avtorji:ID Vivoda Tomšič, Martina, Klinika Golnik, Medicinska fakulteta UL (Avtor)
ID Korošec, Peter, Klinika Golnik, Fakulteta za farmacijo UL (Avtor)
ID Kovač, Viljem, Onkološki inštitut (Avtor)
ID Bisdas, Sotirios (Avtor)
ID Šurlan Popović, Katarina, Onkološki inštitut (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (1,55 MB)
MD5: 88521B170EAE3D84233A652990669508
 
URL URL - Izvorni URL, za dostop obiščite https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8859879/pdf/12885_2022_Article_9277.pdf
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:The malignant pleural mesothelioma (MPM) response rate to chemotherapy is low. The identification of imaging biomarkers that could help guide the most effective therapy approach for individual patients is highly desirable. Our aim was to investigate the dynamic contrast-enhanced (DCE) MR parameters as predictors for progression-free (PFS) and overall survival (OS) in patients with MPM treated with cisplatin-based chemotherapy. Methods: Thirty-two consecutive patients with MPM were enrolled in this prospective study. Pretreatment and intratreatment DCE-MRI were scheduled in each patient. The DCE parameters were analyzed using the extended Tofts (ET) and the adiabatic approximation tissue homogeneity (AATH) model. Comparison analysis, logistic regression and ROC analysis were used to identify the predictors for the patient's outcome. Results: Patients with higher pretreatment ET and AATH-calculated Ktrans and ve values had longer OS (P≤.006). Patients with a more prominent reduction in ET-calculated Ktrans and kep values during the early phase of chemotherapy had longer PFS (P =.008). No parameter was identified to predict PFS. Pre-treatment ET-calculated Ktrans was found to be an independent predictive marker for longer OS (P=.02) demonstrating the most favourable discrimination performance compared to other DCE parameters with an estimated sensitivity of 89% and specificity of 78% (AUC 0.9, 95% CI 0.74-0.98, cut off > 0.08 min-1). Conclusions: In the present study, higher pre-treatment ET-calculated Ktrans values were associated with longer OS. The results suggest that DCE-MRI might provide additional information for identifying MPM patients that may respond to chemotherapy.
Ključne besede:cisplatin, magnetic resonance imaging, mesothelioma
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Kraj izida:Velika Britanija
Založnik:Springer Nature
Leto izida:2022
Št. strani:str. 191-1-191-11
Številčenje:Vol. 22, iss. 1
PID:20.500.12556/DiRROS-14960 Novo okno
UDK:616-07
ISSN pri članku:1471-2407
DOI:10.1186/s12885-022-09277-x Novo okno
COBISS.SI-ID:99703043 Novo okno
Avtorske pravice:© The Author(s) 2022
Opomba:Nasl. z nasl. zaslona; Opis vira z dne 2. 2. 2022;
Datum objave v DiRROS:06.04.2022
Število ogledov:2180
Število prenosov:789
Metapodatki:XML DC-XML DC-RDF
:
VIVODA TOMŠIČ, Martina, KOROŠEC, Peter, KOVAČ, Viljem, BISDAS, Sotirios in ŠURLAN POPOVIĆ, Katarina, 2022, Dynamic contrast-enhanced MRI in malignant pleural mesothelioma : prediction of outcome based on DCE-MRI measurements in patients undergoing cytotoxic chemotherapy. BMC cancer [na spletu]. 2022. Vol. 22, no. 1, p. 191-1-191–11. [Dostopano 30 marec 2025]. DOI 10.1186/s12885-022-09277-x. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=14960
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Gradivo je del revije

Naslov:BMC cancer
Skrajšan naslov:BMC Cancer
Založnik:BioMed Central
ISSN:1471-2407
COBISS.SI-ID:2434324 Novo okno

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:20.02.2022

Sekundarni jezik

Jezik:Ni določen
Ključne besede:cisplatin, slikanje z magnetno resonanco, mezoteliom


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