| Title: | The efficacy, safety and tolerability of canakinumab in the treatment of familial Mediterranean fever : a systematic review of the literature |
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| Authors: | ID Kačar, Mark, Klinika Golnik (Author)
ID Savic, Sinisa (Author)
ID van der Hilst, Jeroen CH (Author) |
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| Files: |  PDF - Presentation file, download (463,72 KB)
MD5: D1827B5AB0D1319B2A600CD477DADF9E
 URL - Source URL, visit https://www.dovepress.com/getfile.php?fileID=56642
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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| Abstract: | Familial Mediterranean Fever (FMF) is the most prevalent genetic autoinflammatory disorder. In most patients, treatment with colchicine can prevent attacks of fever and inflammation. However, 5%-10% of patients are resistant to colchicine treatment, while a similar percentage cannot tolerate colchicine in doses needed to prevent attacks. For these patients, Canakinumab, a full human antibody against IL-1[beta], has been approved recently by the FDA and EMA. In this article, we present a systematic review of the long-term efficacy, safety, and tolerability of Canakinumab in FMF patients who cannot tolerate colchicine or who are resistant to colchicine treatment. |
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| Keywords: | familial Mediterranean fever -- therapy -- review, monoclonal antibodies, canakinumab, anti-IL1 therapy |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Place of publishing: | Nova Zelandija |
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| Publisher: | Dove Press |
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| Year of publishing: | 2020 |
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| Number of pages: | str. 141-149 |
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| Numbering: | Vol. 13 |
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| PID: | 20.500.12556/DiRROS-13873  |
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| UDC: | 577.2 |
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| ISSN on article: | 1178-7031 |
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| DOI: | 10.2147/JIR.S206204 |
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| COBISS.SI-ID: | 58075139 |
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| Copyright: | © 2020 Kacar et al. |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 1. 4. 2021;
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| Publication date in DiRROS: | 08.04.2021 |
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| Views: | 1295 |
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| Downloads: | 759 |
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