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Naslov:Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma : an international multicenter study
Avtorji:ID Brčić, Luka (Avtor)
ID Klikovits, Thomas (Avtor)
ID Megyesfalvi, Zsolt (Avtor)
ID Mosleh, Berta (Avtor)
ID Sinn, Katharina (Avtor)
ID Hritcu, Richard (Avtor)
ID Laszlo, Viktoria (Avtor)
ID Čufer, Tanja, Klinika Golnik, Medicinska fakulteta UL (Avtor)
ID Rozman, Aleš, Klinika Golnik, Medicinska fakulteta UL (Avtor)
ID Kern, Izidor, Klinika Golnik (Avtor)
ID Mohorčič, Katja, Klinika Golnik (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://tlcr.amegroups.com/issue/publishAheadOfPrint
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Background: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM). Methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples from 203 MPM patients receiving standard treatment without immunotherapy were collected from 5 European centers. PD-L1 and PD-1 expression of tumor cells (TCs) and tumor-infiltrating lymphocytes (TILs) were measured by immunohistochemistry and correlated with clinical parameters and long-term outcome. Results: High (>10%) PD-L1 TC and PD-1 TILs expressions were found in 18 (8%) and 39 (24%) patients, respectively. PD-L1 was rarely expressed by TILs [>/=1%, n=13 (8%); >10%, n=1]. No significant associations were found between the PD-L1 or PD-1 expression of TCs or TILs and clinicopathological parameters such as stage or histological subtype. Notably, patients with high (>10%) TC-specific PD-L1 expression exhibited significantly worse median overall survival (OS) (6.3 vs. 15.1 months of those with low TC PD-L1 expression; HR: 2.51, P<0.001). In multivariate cox regression analysis adjusted for clinical parameters, high TC PD-L1 expression (>10%) proved to be an independent negative prognostic factor for OS (HR: 2.486, P=0.005). There was no significant correlation between PD-L1 or PD-1 expression of TILs and OS. Conclusions: In this multicenter cohort study, we demonstrate that high (>10%) PD-L1 expression of TCs independently predicts worse OS in MPM. Further studies are warranted to investigate the value of PD-L1/PD-1 expression as a marker for treatment response in MPM patients receiving immunotherapy.
Ključne besede:mesothelioma - anatomy and histology - analysis, 1malignant pleural mesothelioma, programmed death-ligand 1, programmed cell death 1, PD-L1
Status publikacije:V tisku
Verzija publikacije:Recenzirani rokopis
Kraj izida:Kitajska
Založnik:AME Publishing
Leto izida:2021
Št. strani:str. 1-14
Številčenje:Vol. 10, no.
PID:20.500.12556/DiRROS-13805 Novo okno
UDK:616-006
ISSN pri članku:2226-4477
DOI:10.21037/tlcr-20-1114 Novo okno
COBISS.SI-ID:56719619 Novo okno
Avtorske pravice:© Translational Lung Cancer Research
Opomba:Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Tanja Cufer, Ales Rozman, Izidor Kern, Katja Mohorcic; Opis vira z dne 22. 3. 2021;
Datum objave v DiRROS:31.03.2021
Število ogledov:1913
Število prenosov:767
Metapodatki:XML DC-XML DC-RDF
:
BRČIĆ, Luka, KLIKOVITS, Thomas, MEGYESFALVI, Zsolt, MOSLEH, Berta, SINN, Katharina, HRITCU, Richard, LASZLO, Viktoria, ČUFER, Tanja, ROZMAN, Aleš, KERN, Izidor in MOHORČIČ, Katja, 2021, Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma : an international multicenter study. Translational lung cancer research [na spletu]. 2021. Vol. 10, p. 1–14. [Dostopano 20 marec 2025]. DOI 10.21037/tlcr-20-1114. Pridobljeno s: https://tlcr.amegroups.com/issue/publishAheadOfPrint
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Gradivo je del revije

Naslov:Translational lung cancer research
Skrajšan naslov:Transl. lung cancer res.
Založnik:Pioneer Bioscience
ISSN:2226-4477
COBISS.SI-ID:17120003 Novo okno

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:28.01.2021

Sekundarni jezik

Jezik:Ni določen
Ključne besede:mezoteliom - anatomija in histologija - analiza, maligni plevralni mezoteliom, ligand programirane celične smrti 1, programirana celična smrt 1, PD-L1


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