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Title:Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma : an international multicenter study
Authors:ID Brčić, Luka (Author)
ID Klikovits, Thomas (Author)
ID Megyesfalvi, Zsolt (Author)
ID Mosleh, Berta (Author)
ID Sinn, Katharina (Author)
ID Hritcu, Richard (Author)
ID Laszlo, Viktoria (Author)
ID Čufer, Tanja, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Rozman, Aleš, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Kern, Izidor, Klinika Golnik (Author)
ID Mohorčič, Katja, Klinika Golnik (Author)
Files:URL URL - Source URL, visit https://tlcr.amegroups.com/issue/publishAheadOfPrint
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Background: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM). Methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples from 203 MPM patients receiving standard treatment without immunotherapy were collected from 5 European centers. PD-L1 and PD-1 expression of tumor cells (TCs) and tumor-infiltrating lymphocytes (TILs) were measured by immunohistochemistry and correlated with clinical parameters and long-term outcome. Results: High (>10%) PD-L1 TC and PD-1 TILs expressions were found in 18 (8%) and 39 (24%) patients, respectively. PD-L1 was rarely expressed by TILs [>/=1%, n=13 (8%); >10%, n=1]. No significant associations were found between the PD-L1 or PD-1 expression of TCs or TILs and clinicopathological parameters such as stage or histological subtype. Notably, patients with high (>10%) TC-specific PD-L1 expression exhibited significantly worse median overall survival (OS) (6.3 vs. 15.1 months of those with low TC PD-L1 expression; HR: 2.51, P<0.001). In multivariate cox regression analysis adjusted for clinical parameters, high TC PD-L1 expression (>10%) proved to be an independent negative prognostic factor for OS (HR: 2.486, P=0.005). There was no significant correlation between PD-L1 or PD-1 expression of TILs and OS. Conclusions: In this multicenter cohort study, we demonstrate that high (>10%) PD-L1 expression of TCs independently predicts worse OS in MPM. Further studies are warranted to investigate the value of PD-L1/PD-1 expression as a marker for treatment response in MPM patients receiving immunotherapy.
Keywords:mesothelioma - anatomy and histology - analysis, 1malignant pleural mesothelioma, programmed death-ligand 1, programmed cell death 1, PD-L1
Publication status:In print
Publication version:Author Accepted Manuscript
Place of publishing:Kitajska
Publisher:AME Publishing
Year of publishing:2021
Number of pages:str. 1-14
Numbering:Vol. 10, no.
PID:20.500.12556/DiRROS-13805 New window
UDC:616-006
ISSN on article:2226-4477
DOI:10.21037/tlcr-20-1114 New window
COBISS.SI-ID:56719619 New window
Copyright:© Translational Lung Cancer Research
Note:Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Tanja Cufer, Ales Rozman, Izidor Kern, Katja Mohorcic; Opis vira z dne 22. 3. 2021;
Publication date in DiRROS:31.03.2021
Views:1917
Downloads:769
Metadata:XML DC-XML DC-RDF
:
BRČIĆ, Luka, KLIKOVITS, Thomas, MEGYESFALVI, Zsolt, MOSLEH, Berta, SINN, Katharina, HRITCU, Richard, LASZLO, Viktoria, ČUFER, Tanja, ROZMAN, Aleš, KERN, Izidor and MOHORČIČ, Katja, 2021, Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma : an international multicenter study. Translational lung cancer research [online]. 2021. Vol. 10, p. 1–14. [Accessed 22 March 2025]. DOI 10.21037/tlcr-20-1114. Retrieved from: https://tlcr.amegroups.com/issue/publishAheadOfPrint
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Record is a part of a journal

Title:Translational lung cancer research
Shortened title:Transl. lung cancer res.
Publisher:Pioneer Bioscience
ISSN:2226-4477
COBISS.SI-ID:17120003 New window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:28.01.2021

Secondary language

Language:Undetermined
Keywords:mezoteliom - anatomija in histologija - analiza, maligni plevralni mezoteliom, ligand programirane celične smrti 1, programirana celična smrt 1, PD-L1


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