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Title:Intraperitonealna aerosolna kemoterapija pod povišanim pritiskom
Authors:ID Brecelj, Erik (Author)
ID Kopriva Pirtovšek, Katja (Author)
ID Izlakar, Jani (Author)
ID Boc, Nina (Author)
Files:.pdf PDF - Presentation file, download (96,21 KB)
MD5: C7C89D8D1AEC851B341DD028F12EC7B8
 
Language:Slovenian
Typology:1.04 - Professional Article
Organization:Logo OI - Institute of Oncology
Abstract:Bolniki s peritonealnimi metastazami imajo kljub multimodalnemu zdravljenju s kirurgijo in kemoterapijo slabo prognozo. Samo citoreduktivna kirurgija je lahko kurativna pri zdravljenju peritonealne karcinoze, toda le manjši delež bolnikov je primeren za kirurško zdravljenje. Pri neresektabilni peritonealni karcinozi je kemoterapija edina možna terapija z omejenim učinkom na peritonealne metastaze zaradi slabe vaskularizacije in nizke penetracije zdravila. Intraperitonealna aerosolna kemoterapija pod pritiskom (PIPAC) je nova minimalno invazivna metoda, ki s pomočjo laparoskopije omogoča aplikacijo citostatika v abdomen v obliki aerosolov pod povišanim pritiskom, kar omogoča boljšo razporeditev zdravila v abdominalni votlini in globjo penetracijo zdravila. PIPAC je tehnično varen postopek, ki omogoča zdravljenje izolirane peritonealne karcinoze različnih vrst tumorjev. Objavljeni rezultati zdravljenja peritonealnih metastaz različnih vrst tumorjev s PIPAC so obetavni. Trenutno potekajo številne prospektivne študije, ki analizirajo terapevtsko učinkovitost PIPAC-a pri različnih indikacijah z različnimi zdravili.
Keywords:karcinoza peritoneja, intraperitonealna kemoterapija, PIPAC, kirurgija
Publication status:Published
Publication version:Version of Record
Year of publishing:2019
Number of pages:str. 38-41
Numbering:Letn. 23, št. 2
PID:20.500.12556/DiRROS-10482 New window
UDC:616
ISSN on article:1408-1741
DOI:10.25670/oi2019-017on New window
COBISS.SI-ID:3414395 New window
Copyright:by Authors
Publication date in DiRROS:13.01.2020
Views:3275
Downloads:911
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Record is a part of a journal

Title:Onkologija
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:13.01.2020

Secondary language

Language:English
Title:Pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Abstract:Patients with peritoneal carcinomatosis have a poor prognosis despite multimodal treatment with surgery and chemotherapy. Cytoreductive surgery is the only curative option for the treatment of carcinomatosis but only minority of patients are eligible for surgical treatment. For non-resectable peritoneal carcinomatosis, chemotherapy is the only possible option with limited effect on the peritoneal metastases due to poor vascularization and low penetration of the drug. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a new minimally invasive method using laparoscopy to deliver chemotherapy in the form of pressurized aerosol into the abdomen allowing better distribution of the drug in the abdominal cavity and deeper penetration of the drug. PIPAC is technically feasible and safe procedure useful as a treatment option for isolated peritoneal carcinomatosis of various origins. Promising results have been published in the treatment of the peritoneal metastases of all origin with PIPAC. Many prospective clinical trials are ongoing evaluating oncological efficacy of PIPAC in multiple indications with various drugs.


Collection

This document is a part of these collections:
  1. Onkologija : strokovni časopis za zdravnike

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