41. Engineered combinatorial cell device for wound healing and bone regenerationLucija Kadunc, Duško Lainšček, Rok Gašperšič, Petra Sušjan, Uroš Kovačič, Miha Butinar, Boris Turk, Roman Jerala, Iva Hafner Bratkovič, 2023, original scientific article Abstract: Growth factors are the key regulators that promote tissue regeneration and healing processes. While the effects of individual growth factors are well documented, a combination of multiple secreted growth factors underlies stem cell–mediated regeneration. To avoid the potential dangers and laborintensive individual approach of stem cell therapy while maintaining their regeneration-promoting effects based on multiple secreted growth factors, we engineered a “mix-and-match” combinatorial platform based on a library of cell lines producing growth factors. Treatment with a combination of growth factors secreted by engineered mammalian cells was more efficient than with individual growth factors or even stem cell–conditioned medium in a gap closure assay. Furthermore, we implemented in a mouse model a device for allogenic cell therapy for an in situ production of growth factors, where it improved cutaneous wound healing. Augmented bone regeneration was achieved on calvarial bone defects in rats treated with a cell device secreting IGF, FGF, PDGF, TGF-β, and VEGF. In both in vivo models, the systemic concentration of secreted factors was negligible, demonstrating the local effect of the regeneration device. Finally, we introduced a genetic switch that enables temporal control over combinations of trophic factors released at different stages of regeneration mimicking the maturation of natural wound healing to improve therapy and prevent scar formation.
Keywords: wound healing, bone regeneration, growth factors
Published in DiRROS: 01.06.2023; Views: 495; Downloads: 193
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42. Seismic activity in the Celje Basin (Slovenia) in Roman times—archaeoseismological evidence from CeleiaMiklós Kázmér, Petra Jamšek Rupnik, Krzysztof Gaidzik, 2023, original scientific article Abstract: Searching for unknown earthquakes in Slovenia in the first millennium, we performed archaeoseismological analysis of Roman settlements. The Mesto pod mestom museum in Celje exhibits a paved Roman road, which suffered severe deformation. Built on fine gravel and sand from the Savinja River, the road displays a bulge and trench, pop-up structures, and pavement slabs tilted up to 40°. The city wall was built over the deformed road in Late Roman times, supported by a foundation containing recycled material (spolia) from public buildings, including an emperor’s statue. We hypothesize that a severe earthquake hit the town before 350 AD, causing widespread destruction. Seismic-induced liquefaction caused differential subsidence, deforming the road. One of the nearby faults from the strike-slip Periadriatic fault system was the seismic source of this event.
Keywords: paleoseismology, Periadriatic fault system, active tectonics, Southern Alps, Pannonian Basin, Dinarides
Published in DiRROS: 14.02.2023; Views: 474; Downloads: 156
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43. Communication plan : Forest in women’s hands (Fem4Forest)Amina Trle, Ajla Dorfer, Tina Jemec, M. Handlos, Kathrin Böhling, Maja Merc Kiš, Lesya Loyko, Jelena Nedeljković, Ramona Scriban, Petra Palátová, Ivan Paligorov, 2020, treatise, preliminary study, study Keywords: Forests in women's hands, Fem4Forest, role of women, communication plan
Published in DiRROS: 07.02.2023; Views: 373; Downloads: 110
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45. Pomen izvora raziskovalnih podatkov (provenience) pri interoperabilnosti in ponovni uporabi : spletni dogodek v okviru Odprte akademije, 24. jan. 2022Mitja Vovk Iskrić, Petra Durini, Maja Vihar, Uroš Kunaver, Miro Pušnik, Maja Peteh, Nana Turk, Darko Majcenović, 2022, professional film, videorecordings or sound recordings Published in DiRROS: 24.01.2023; Views: 507; Downloads: 202
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46. Odprta znanost v programu Obzorje Evropa : diseminacija, temeljna načela odprte znanosti, odprti dostop, ravnanje z raziskovalnimi podatki, Ravnanje z raziskovalnimi podatkiPetra Durini, Maja Vihar, Nana Turk, Uroš Kunaver, Mitja Vovk Iskrić, Tilen Mandelj, Miro Pušnik, 2022, professional film, videorecordings or sound recordings Published in DiRROS: 24.01.2023; Views: 427; Downloads: 138
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49. Odprta znanost v programu Obzorje Evropa : razširjanje rezultatov, temeljna načela odprte znanosti, odprti dostopMitja Vovk Iskrić, Maja Vihar, Petra Durini, Uroš Kunaver, Miro Pušnik, 2021, professional film, videorecordings or sound recordings Keywords: znanstveno raziskovanje, odprta znanost, knjižnično informacijska dejavnost, podpora raziskovalcem, Obzorje Evropa
Published in DiRROS: 05.01.2023; Views: 482; Downloads: 145
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