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Query: "author" (Stegel Vida) .

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11.
Real-world data on detection of germline and somatic pathogenic/likely pathogenic variants in BRCA1/2 and other susceptibility genes in ovarian cancer patients using next generation sequencing
Vida Stegel, Ana Blatnik, Erik Škof, Vita Šetrajčič Dragoš, Mateja Krajc, Brigita Gregorčič, Petra Škerl, Ksenija Strojnik, Gašper Klančar, Marta Banjac, Janez Žgajnar, Maja Ravnik-Oblak, Srdjan Novaković, 2022, original scientific article

Abstract: Detection of germline and somatic pathogenic/likely pathogenic variants (PV/LPV) in BRCA genes is at the moment a prerequisite for use of PARP inhibitors in different treatment settings of different tumors. The aim of our study was to determine the most appropriate testing workflow in epithelial ovarian cancer (EOC) patients using germline and tumor genotyping of BRCA and other hereditary breast and/or ovarian cancer (HBOC) susceptibility genes. Consecutive patients with advanced non-mucinous EOC, who responded to platinum-based chemotherapy, were included in the study. DNA extracted from blood and FFPE tumor tissue were genotyped using NGS panels TruSightCancer/Hereditary and TruSight Tumor 170. Among 170 EOC patients, 21.8% had BRCA germline or somatic PV/LPV, and additionally 6.4% had PV/LPV in other HBOC genes. Sensitivity of tumor genotyping for detection of germline PV/LPV was 96.2% for BRCA genes and 93.3% for HBOC genes. With germline genotyping-only strategy, 58.8% of HBOC PV/LPV and 68.4% of BRCA PV/LPV were detected. By tumor genotyping-only strategy, 96.1% of HBOC PV/LPV and 97.4% of BRCA PV/LPV were detected. Genotyping of tumor first, followed by germline genotyping seems to be a reasonable approach for detection of PV/LPV in breast and/or ovarian cancer susceptibility genes in non-mucinous EOC patients.
Keywords: BRCA, ovarian cancer, tumor genotyping, HBOC
Published in DiRROS: 06.09.2022; Views: 482; Downloads: 266
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13.
Vloga molekularne diagnostike pri raku jajčnikov
Vida Stegel, Srdjan Novaković, 2021, published scientific conference contribution abstract

Keywords: rak jajčnikov, molekularna diagnostika, laboratorijski izvidi
Published in DiRROS: 16.06.2021; Views: 1006; Downloads: 482
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14.
Dokazovanje mutacij v BRCA1 genu z analizo talitvene krivulje PCR produktov
Srdjan Novaković, Vida Stegel, Mateja Krajc, Janez Žgajnar, Nikola Bešić, Marko Hočevar, Cvetka Bilban-Jakopin, Katarina Lokar, 2006, published scientific conference contribution

Published in DiRROS: 17.09.2019; Views: 2332; Downloads: 586
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15.
Dedni rak širokega črevesa
Mateja Krajc, Janez Žgajnar, Nikola Bešić, Marko Hočevar, Cvetka Bilban-Jakopin, Katarina Lokar, Srdjan Novaković, Vida Stegel, 2006, published professional conference contribution

Published in DiRROS: 17.09.2019; Views: 1996; Downloads: 529
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16.
Priprava hibridomov iz monocitov in tumorskih celic
Vida Stegel, Andreja Nataša Kopitar, Srdjan Novaković, 2004, published professional conference contribution abstract

Published in DiRROS: 17.09.2019; Views: 2259; Downloads: 520
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18.
Detekcija telomerazne mRNA v plazmi bolnic s karcinomom dojke
Vida Stegel, Janez Žgajnar, Srdjan Novaković, 2004, published professional conference contribution abstract

Published in DiRROS: 16.09.2019; Views: 1947; Downloads: 441
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19.
Dedni rak dojk in jajčnikov
Janez Žgajnar, Mateja Krajc, Nikola Bešić, Marko Hočevar, Cvetka Bilban-Jakopin, Katarina Lokar, Srdjan Novaković, Vida Stegel, Miljeva Rener, Aleš Vakselj, 2006, published professional conference contribution

Published in DiRROS: 16.09.2019; Views: 1662; Downloads: 457
.pdf Full text (213,19 KB)

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