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42. Vinblastine increases antitumor effectiveness of bleomycinMaja Čemažar, Marija Auersperg, Gregor Serša, 1997, original scientific article Abstract: In our previous vinblastine (VELBE) was shown to increase the plasma membrane fluidity. This effect of VELBE might be expolited for better transport of drugs through the plasma membrane. Bleomycin (BLM) is a highly cytotoxic drug when present inside the cells but has a hampered transport through the plasma membrane. The aim of the present study was to determine whether pretreatment with VELBE can increase the effect of BLM on intraperitoneal SA-1 tumors in mice. BLM and VELBE were used as single agents or in various combinations, i.e. VELBE and BLM injected simultanously, BLM injected 24 h before VELBE or VELBE injected 24 h before BLM. Mice survival was the end-point used for determining the effect of this combined treatments. VELBE and BLM as a single treatment significantly prolonged median survival time of study animals compared to controls. Furthermore, when VELBE and BLM were combined, all threetested combinations were more effective than VELBE or BLM as single treatments. The effect on animal survival was equal when VELBE was given 24 h after or simultanously with BLM. The longest survival, however was obtained when VELBE was injected 24 h before BLM. From these results we can conclude that the underlying mechanisms for more than additive effect of VELBE and BLM when VELBE was given 24 h before BLM could be attributed to an increased membrane fluidity, possibly in combination with a cell kinetic effect.
Published in DiRROS: 18.01.2024; Views: 161; Downloads: 37
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43. Study of blood perfusion with patent blue staining method in LPB fibrosarcoma tumors in immuno-competent and immuno-deficient mice after electrotherapy by direct currentTomaž Jarm, Dong Jian An, Jean Belehradek, Lluis M. Mir, Gregor Serša, Maja Čemažar, Tadej Kotnik, Jani Pušenjak, Damijan Miklavčič, 1997, original scientific article Published in DiRROS: 16.01.2024; Views: 176; Downloads: 39
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45. Electrochemotherapy with bleomycin : The first clinical experience in malignant melanoma patientsZvonimir Rudolf, Borut Štabuc, Maja Čemažar, Damijan Miklavčič, Lojze Vodovnik, Gregor Serša, 1995, original scientific article Keywords: melanoma therapy, bleomycin, electric stimulation therapy
Published in DiRROS: 15.01.2024; Views: 213; Downloads: 48
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46. Improved therapeutic effect of electrochemotherapy with cisplatin by intratumoral drug administration and changing of electrode orientation for electropermeabilization on EAT tumor model in miceMaja Čemažar, Damijan Miklavčič, Lojze Vodovnik, Tomaž Jarm, Zvonimir Rudolf, Borut Štabuc, Tanja Čufer, Gregor Serša, 1995, original scientific article Keywords: neoplasmas, experimental therapy, cisplatin, electric stimulation therapy, cell membrane permeability
Published in DiRROS: 15.01.2024; Views: 181; Downloads: 50
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50. Elektrokemoterapija pri lokalnem zdravljenju napredovalega melanomaGregor Serša, Zvonimir Rudolf, Marija Snežna Paulin-Košir, Janja Ocvirk, Maja Čemažar, Simona Kranjc Brezar, Breda Slekovec Kolar, Marko Snoj, 2007, published scientific conference contribution Published in DiRROS: 06.12.2023; Views: 222; Downloads: 60
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