41. Priporočila za obravnavo bolnikov s pljučnim rakomMartina Vrankar, Nina Boc, Izidor Kern, Aleš Rozman, Karmen Stanič, Tomaž Štupnik, Mojca Unk, Maja Ebert Moltara, Vesna Zadnik, Katja Adamič, Jernej Benedik, Marko Bitenc, Jasna But-Hadžić, Anton Crnjac, Marina Čakš, Dominik Časar, Eva Ćirić, Tanja Čufer, Ana Demšar, Rok Devjak, Goran Gačevski, Marta Globočnik Kukovica, Kristina Gornik-Kramberger, Maja Ivanetič Pantar, Marija Ivanović, Urška Janžič, Staša Jelerčič, Veronika Kloboves-Prevodnik, Mile Kovačević, Luka Ležaič, Mateja Marc-Malovrh, Katja Mohorčič, Loredana Mrak, Igor Požek, Nina Turnšek, Bogdan Vidmar, Dušanka Vidovič, Gregor Vlačić, Ana Lina Vodušek, Rok Zbačnik, Ivana Žagar, 2023, strokovni članek Povzetek: Leta 2019 so bila objavljena Priporočila za obravnavo bolnikov s pljučnim rakom, ki so v slovenski prostor vnesla prepotrebno poenotenje diagnostike in zdravljenja z namenom izboljšanja preživetja bolnikov s pljučnim rakom. Posodobitev Priporočil tri leta po izidu izvirnika prinaša največ novosti v poglavju o sistemskem zdravljenju bolnikov s pljučnim rakom. To kaže na izjemen napredek na področju razumevanja onkogeneze in biologije pljučnega raka ter s tem razvoja novih zdravil. Breme pljučnega raka ostaja veliko, saj je pljučni rak pri nas in v svetu še vedno najpogostejši vzrok smrti zaradi raka. Za vsako peto smrt zaradi raka je odgovoren pljučni rak. Skoraj tretjina bolnikov s pljučnim rakom ne prejme specifičnega onkološkega zdravljenja, bodisi zaradi slabega stanja zmogljivosti, spremljajočih bolezni ali obsega bolezni. Polovica bolnikov ima ob diagnozi razsejano bolezen, zaradi česar izboljšanje preživetja z malimi koraki sledi napredku v zdravljenju bolnikov s pljučnim rakom. Ti podatki nas opominjajo, da se bomo morali za velike premike v obravnavi bolnikov s pljučnim rakom lotiti drugačnih pristopov. Kot najbolj obetavno se ponuja zgodnje odkrivanje bolezni, ko so možnosti ozdravitve pljučnega raka najboljše. Zapisana Priporočila so usmeritev za obravnavo bolnikov s pljučnim rakom. Le s sodobnim multidisciplinarnim pristopom obravnave lahko bolniku ponudimo zdravljenje, ki mu omogoča najboljši izhod prognostično neugodne bolezni.
Ključne besede: pljučni rak, priporočila
Objavljeno v DiRROS: 27.07.2023; Ogledov: 422; Prenosov: 148
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42. Hodgkinov limfom : vodnik za bolnikeBarbara Jezeršek Novaković, Samo Zver, Metka Zajc, Aleksandra Grbič, Andreja Cirila Škufca Smrdel, Eda Vrtačnik-Bokal, Vesna Šalamun, Nina Kovačević, Lorna Zadravec-Zaletel, Matej Pečovnik, 2022, ni določena Ključne besede: rak (medicina), krvotvorne matične celice, transplantacija, psihološka pomoč, plodnost, hormonsko nadomestno zdravljenje
Objavljeno v DiRROS: 24.07.2023; Ogledov: 393; Prenosov: 89
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43. Characterizing steel corrosion in different alkali-activated mortarsNina Gartner, Miha Hren, Tadeja Kosec, Andraž Legat, 2021, izvirni znanstveni članek Povzetek: Alkali-activated materials (AAMs) present a promising potential alternative to ordinary Portland cement (OPC). The service life of reinforced concrete structures depends greatly on the corrosion resistance of the steel used for reinforcement. Due to the wide range and diverse properties of AAMs, the corrosion processes of steel in these materials is still relatively unknown. Three different alkali-activated mortar mixes, based on fly ash, slag, or metakaolin, were prepared for this research. An ordinary carbon-steel reinforcing bar was installed in each of the mortar mixes. In order to study the corrosion properties of steel in the selected mortars, the specimens were exposed to a saline solution in wet/dry cycles for 17 weeks, and periodic electrochemical impedance spectroscopy (EIS) measurements were performed. The propagation of corrosion damage on the embedded steel bars was followed using X-ray computed microtomography (XCT). Periodic EIS measurements of the AAMs showed different impedance response in individual AAMs. Moreover, these impedance responses also changed over the time of exposure. Interpretation of the results was based on visual and numerical analysis of the corrosion damages obtained by XCT, which confirmed corrosion damage of varying type and extent on steel bars embedded in the tested AAMs.
Ključne besede: corrosion, alkali-activated mortars, steel reinforcement, electrochemical impedance spectroscopy, X-ray computed microtomography, visual analysis
Objavljeno v DiRROS: 05.07.2023; Ogledov: 390; Prenosov: 182
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44. Advanced method for efficient functionalization of polymers by intermediate free-radical formation with vacuum-ultraviolet radiation and producing superhydrophilic surfacesAlenka Vesel, Rok Zaplotnik, Miran Mozetič, Nina Recek, 2023, izvirni znanstveni članek Povzetek: An efficient approach for tailoring surface properties of polymers is presented, which enables rapid modification leading to superhydrophilic properties. The approach is based on vacuum-ultraviolet radiation (VUV) pretreatment of the surface to create reactive dangling bonds. This step is followed by a second treatment using neutral oxygen atoms that react with the dangling bonds and form functional groups. The beneficial effect of VUV pretreatment for enhanced functionalization was clearly demonstrated by comparing VUV pretreatment in plasmas created in different gases, i.e., hydrogen, nitrogen, and oxygen, which differ in the intensity of VUV/UV radiation. The emission intensity of VUV radiation for all gases was measured by vacuum ultraviolet spectroscopy. It was shown that VUV has a strong influence on the treatment time and final surface wettability. A superhydrophilic surface was obtained only if using VUV pretreatment. Furthermore, the treatment time was significantly reduced to only a second of treatment. These findings show that such an approach may be used to enhance the surface reaction efficiency for further grafting of chemical groups.
Ključne besede: plasma treatment, vacuum-ultraviolet radiation treatment, surface functionalization, polymer polyvinyl chloride, vacuum-ultraviolet spectroscopy, vacuum-ultraviolet photons
Objavljeno v DiRROS: 06.06.2023; Ogledov: 422; Prenosov: 206
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45. Kirurško zdravljenje visoko rizičnega raka telesa materniceNina Kovačević, 2023, objavljeni znanstveni prispevek na konferenci Povzetek: Rak materničnega telesa je najpogostejši ginekološki rak in v Sloveniji vsako leto odkrijemo približno 350 novih primerov. Večino rakov materničnega telesa predstavlja rak endometrija, ki ga delimo v dve skupini, in sicer estrogensko odvisni in estrogensko neodvisni rak endometrija. Zdravljenje je v prvi vrsti kirurško, obseg operativnega posega je določen glede verjetnosti ponovitve. Kirurškemu zdravljenju je lahko dodano obsevanje, sistemska terapija ali kombinacija obojega.
Ključne besede: rak maternice, ginekološki raki, ginekološka onkologija
Objavljeno v DiRROS: 30.05.2023; Ogledov: 371; Prenosov: 154
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46. Application of electrochemical methods for studying steel corrosion in alkali-activated materialsShishir Mundra, Gabriel Samson, Giulia Masi, Rebecca Achenbach, David M. Bastidas, Susana Bernal, Maria Chiara Bignozzi, Maria Criado, Martin Cyr, Nina Gartner, Stefanie von Greve‐Dierfeld, Andraž Legat, Nikoonasab Ali, John L. Provis, Michael Raupach, Gregor J. G. Gluth, 2023, izvirni znanstveni članek Povzetek: Alkali‐activated materials (AAMs) are binders that can complement and partially substitute the current use of conventional cement. However, the present knowledge about how AAMs protect steel reinforcement in concrete elements is incomplete, and uncertainties exist regarding the application of electrochemical methods to investigate this issue. The present review by EFC WP11‐Task Force ‘Corrosion of steel in alkali‐activated materials’ demonstrates that important differences exist between AAMs and Portland cement, and between different classes of AAMs, which are mainly caused by differing pore solution compositions, and which affect the outcomes of electrochemical measurements. The high sulfide concentrations in blast furnace slag‐based AAMs lead to distinct anodic polarisation curves, unusually low open circuit potentials, and low polarisation resistances, which might be incorrectly interpreted as indicating active corrosion of steel reinforcement. No systematic study of the influence of the steel–concrete interface on the susceptibility of steel to corrosion in AAMs is available. Less common electrochemical methods present an opportunity for future progress in the field.
Ključne besede: alkali-aktivated materials, alkali‐activated materials, anodic/cathodic polarisation, concrete, linear polarisation resistance, open circuit potential, reinforcement corrosion, resistivity
Objavljeno v DiRROS: 29.05.2023; Ogledov: 315; Prenosov: 136
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47. Environmental acceptability of geotechnical composites from recycled materials : comparative study of laboratory and field investigationsMarija Đurić, Vesna Zalar Serjun, Ana Mladenovič, Alenka Mauko Pranjić, Radmila Milačič, Janez Ščančar, Janko Urbanc, Nina Mali, Alenka Sešek Pavlin, Janez Turk, Primož Oprčkal, 2023, izvirni znanstveni članek Povzetek: The environmental properties of three geotechnical composites made by recycling wastes were investigated on a laboratory scale and in the field with the use of lysimeters designated for the revitalization of degraded mining sites. Composites were prepared by combining the mine waste with paper-mill sludge and foundry sand (Composite 1), with digestate from municipal waste and paper ash (Composite 2), and with coal ash, foundry slag and waste incineration bottom ash (Composite 3). The results of laboratory leaching tests proved that Composites 1 and 3 are envi- ronmentally acceptable, according to the legislative limits, as the potentially hazardous substances were immobilized, while in Composite 2, the legislative limits were exceeded. In the field lysimeters, the lowest rate of leaching was determined for optimally compacted Composites 1 and 3, while for Composite 2 the leaching of Cu was high. This study proved that optimally installed Composites 1 and 3 are environmentally acceptable for use in construction as an alternative to virgin materials, for the revitalization of degraded mining sites or, along with Composite 2, for closure operations with landfills. In this way, locally available waste streams are valorised and channelized into a beneficial and sustainable recycling practice.
Ključne besede: waste, recycling, lysimeter, potentiali hazardous substances, immobilization, revitalisation, environmental, open access
Objavljeno v DiRROS: 29.05.2023; Ogledov: 350; Prenosov: 258
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49. Contrasting responses of alien and ancient forest indicator plant species to fragmentation process in the temperate lowland forestsMirjana Šipek, Lado Kutnar, Aleksander Marinšek, Nina Šajna, 2022, izvirni znanstveni članek Povzetek: Fragmentation is one of the major threats to biodiversity. In a fragmented landscape, forest specialists are losing suitable forest habitats with specific site and microclimate conditions, which results in their local extinction. Conversely, the invasion of alien species is facilitated by open forest areas and increased boundaries between forest fragments and adjacent land. We studied the effect of fragmentation in terms of fragment size impact on overall plant species richness and on selected ecologically important groups' richness, composition, and diversity. We surveyed vegetation in the interior of 47 fragments of various sizes and one unfragmented reference forest. Our results reveal that the effect of fragmentation is complex and differs for studied plant groups. Decreasing fragment size negatively affects the overall plant richness and richness of native and ancient forest indicator plants as well as their diversity, while the effect is positive for alien plants. The highest proportion of ancient forest indicator plant species and the lowest proportion of alien plants in the unfragmented forest underline the great conservation value of forest fragments. At the same time, our results reveal that large and diverse forest ecosystems are susceptible to biological invasions as well.
Ključne besede: forest fragment, indicator plants, invasion, diversity, habitat modification, habitat conservation
Objavljeno v DiRROS: 15.05.2023; Ogledov: 358; Prenosov: 191
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50. Sistemsko zdravljenje bolnikov s pljučnim rakom : zaviralci imunskih nadzornih točkNina Turnšek, 2023, objavljeni znanstveni prispevek na konferenci Povzetek: Zaviralci imunskih nadzornih točk (ZINT) predstavljajo pravo revolucijo v sistemskem
zdravljenju raka pljuč in so v zadnjem desetletju korenito spremenili standardno zdravljenje
teh bolnikov. Prepričljivo dobrobit s podaljšanjem preživetja so sprva izkazali kot samostojno
zdravljenje pri bolnikih z razsejanim nedrobnoceličnim rakom pljuč (NDRP), ki je napredoval
po predhodnem zdravljenju s kemoterapijo na osnovi platine. Kmalu zatem je sledil njihov
premik v prvi red zdravljenja razsejane bolezni najprej kot samostojno zdravljenje, nato pa
še v kombinaciji s kemoterapijo na osnovi platine in tudi kot kombinirana imunoterapija
dveh ZINT. Korenito so spremenili tudi obravnavo bolnikov z NDRP v zgodnejših stadijih
bolezni, predvsem lokalno napredovale oblike, še posebej veliko obetajo v perioperativnem
obdobju. Imunoterapija z ZINT se pri raku pljuč uporablja kot monoterapija, kot kombinacija
s kemoterapijo z ali brez zaviralca angiogeneze oziroma kombinacija dveh različnih ZINT.
Ključne besede: pljučni rak, onkološko zdravljenje, bolniki
Objavljeno v DiRROS: 12.05.2023; Ogledov: 345; Prenosov: 76
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