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102. Effects of a mixed O/F ligand in the Tavorite-type LiVPO[sub]4O structureSorour Semsari Parapari, Jean-Marcel Ateba Mba, Elena Tchernychova, Gregor Mali, Iztok Arčon, Gregor Kapun, Mehmet Ali Gülgün, Robert Dominko, 2020, izvirni znanstveni članek Ključne besede: XRD, SEM, V XANES, Tavorite-type, electrochemical properties
Objavljeno v DiRROS: 25.11.2020; Ogledov: 1631; Prenosov: 897
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104. Systemic and airway oxidative stress in competitive swimmersSabina Škrgat, Peter Korošec, Izidor Kern, Mira Šilar, Julij Šelb, Matjaž Fležar, Robert Marčun, 2018, izvirni znanstveni članek Povzetek: Background: The environment in swimming pools, which contain chlorine, might interact with the airway epithelium, resulting in oxidative stress and/or inflammation during high intensity training periods. Methods: We evaluated pulmonary functional (metacholine challenge test, FEV1 and VC), cellular (eosinophils and neutrophils), inflammatory (FeNo, IL-5, IL-6, IL-8 and TNF-[alpha]), oxidative (8-isoprostanes) and angiogenesis factors (VEGF) in induced sputum and peripheral blood of 41 healthy non-asthmatic elite swimmers (median 16 years) during the period of high intensity training before a national championship. The second paired sampling was performed seven months later after training had been stopped for one month. Results: There was a ten-fold increase (median 82-924 pg/ml; P < 0.001) in 8-isoprostanes in induced sputum and five-fold increase (median 82-924 pg/ml; P < 0.001) in sera during training in comparison to the period of rest. However, there was no difference in FEV1 (113 vs 116%), VC (119 vs 118%), FeNo (median 34 vs 38 ppb), eosinophils (2.7 vs 2.9% in sputum; 180 vs 165 cells/[micro]l in blood), neutrophils, different cytokines or VEGF in induced sputum or sera. The only exception was TNF-[alpha], which was moderately increased in sera (median 23 vs 40 pg/ml; P=0.02) during the peak training period. Almost half (18 of 41) of swimmers showed bronchial hyperresponsiveness during the peak training period (PC20 cutoff was 4 mg/ml). There was no correlation between hyperresponsiveness and the markers of oxidative stress or inflammation. Conclusions: High intensity training in healthy, non-asthmatic competitive swimmers results in marked oxidative stress at the airway and systemic levels, but does not lead to airway inflammation. However, we could not confirm that oxidative stress is associated with bronchial hyperresponsiveness (AHR), which is often observed during the peak exercise training period.
Ključne besede: bronchial diseases, swimming, oxidative stress, bronchial hyperresponsiveness, competitive swimmers, training
Objavljeno v DiRROS: 23.11.2020; Ogledov: 1730; Prenosov: 471
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105. Differences in reporting the ragweed pollen season using Google Trends across 15 countriesJean Bousquet, Ioana Agache, Uwe Berger, Karl-Christian Bergmann, Jean-Pierre Besancenot, Philippe J. Bousquet, Thomas Casale, Gennaro d'Amato, Igor Kaidashev, Musa Khaitov, Ralph Mösges, Kristof Nekam, Gabrielle L. Onorato, Davor Plavec, Aziz Sheikh, Michel Thibaudon, Robert Vautard, Mihaela Zidarn, 2018, pregledni znanstveni članek Povzetek: Background: Google Trends (GT) searches trends of specific queries in Google, which potentially reflect the real-life epidemiology of allergic rhinitis. We compared GT terms related to ragweed pollen allergy in American and European Union countries with a known ragweed pollen season. Our aim was to assess seasonality and the terms needed to perform the GT searches and to compare these during the spring and summer pollen seasons. Methods: We examined GT queries from January 1, 2011, to January 4, 2017. We included 15 countries with a known ragweed pollen season and used the standard 5-year GT graphs. We used the GT translation for all countries and the untranslated native terms for each country. Results: The results of "pollen," "ragweed," and "allergy" searches differed between countries, but "ragweed" was clearly identified in 12 of the 15 countries. There was considerable heterogeneity of findings when the GT translation was used. For Croatia, Hungary, Romania, Serbia, and Slovenia, the GT translation was inappropriate. The country patterns of "pollen," "hay fever," and "allergy" differed in 8 of the 11 countries with identified "ragweed" queries during the spring and the summer, indicating that the perception of tree and grass pollen allergy differs from that of ragweed pollen. Conclusions: To investigate ragweed pollen allergy using GT, the term "ragweed" as a plant is required and the translation of "ragweed" in the native language needed.
Ključne besede: allergy and immunology, allergens, seasonal allergic rhinitis, rhinitis, pollen, ambrosia, Google Trends, hay fever
Objavljeno v DiRROS: 20.11.2020; Ogledov: 1225; Prenosov: 262
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106. Uspevanje omorike (Picea omorika (Pančić) Purk.) v generativnem semenskem nasadu Počivalnik pri PostojniSebastian Bambič, Kristjan Jarni, Gregor Božič, Robert Brus, 2020, izvirni znanstveni članek Povzetek: Omorika (Picea omorika (Pančić) Purk.) je endemična drevesna vrsta z Balkanskega polotoka, ki dobro uspeva tudi v Sloveniji in bi bila na nekaterih rastiščih v manjših deležih lahko zanimiva alternativa navadni smreki (Picea abies (L.) Karst.). Raziskavo smo opravili v nasadu omorike pod vrhom hriba Počivalnik med Uncem in Postojno. Drevesa so bila posajena leta 1988 in so zdaj v fazi drogovnjaka. Izmerili smo jim prsni premer in ocenili zdravstveno stanje. Izračunali smo deleže dreves različnih zdravstvenih stanj za posamezne provenience in fenotipe, izdelali model nasada, napravili analizo variance in post hoc test. Ugotovili smo, da imajo provenience velik vpliv na vitalnost dreves, ne pa tudi na debelinski prirastek. Vitalnost dreves se prav tako razlikuje med posameznimi fenotipi. Korelacijo med fenotipi in prsnimi premeri smo potrdili pri dveh od petih fenotipov (B; tip 'semidichotomy', C; tip 'serbica'). Vpliv fenotipa na debelinski prirastek je v različnih proveniencah različen. Glede na našo raziskavo bi bil ob morebitni uporabi za Dinarski kras v Sloveniji najprimernejši semenski material provenience Šargan, najprimernejša fenotipa pa C (tip 'serbica') in F (tip 'argentea'), oba sicer najbolj zaželena tudi v hortikulturi.
Ključne besede: Picea omorika, provenienca, fenotip, vitalnost, ujma, pogozdovanje
Objavljeno v DiRROS: 18.11.2020; Ogledov: 6045; Prenosov: 1723
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107. Expenditures on oncology drugs and cancer mortality-to-incidence ratio in Central and Eastern EuropeEduard Vrdoljak, Gyorgy Bodoky, Jacek Jassem, Razvan A. Popescu, Robert Pirker, Tanja Čufer, Semir Beslija, Alexsandru Eniu, Vladimir Todorović, Katerina Kopečková, 2019, izvirni znanstveni članek Povzetek: Background. There is a steady decline in cancer mortality in Western Europe (WE), but this trend is not so obvious in Central and Eastern Europe (CEE). One of the largest discrepancies between WE and CEE is the level of investment in cancer care. The objective of our analysis was to examine the correlation between mortality-to-incidence (M/I) ratio and expenditures on oncology drugs in CEE and WE. Materials and Methods. This cross-sectional analysis was done on publicly available data. Data on expenditures for oncology drugs were obtained from QuintilesIMS, and data on M/I ratio from Globocan. The main outcome was mortality-to-incidence ratio, and the primary analysis was performed by Spearman's rank correlation. Results. There is a large discrepancy in expenditure on oncology drugs per cancer case between WE and CEE, and within CEE. Average expenditure on oncology drugs per capita as well as per new cancer case was 2.5 times higher in WE than in CEE. Availability of oncology drugs was highest in Germany (100%), relatively similar in WE (average of 91%), but in CEE it ranged from 37% to 86%, with an average of 70%. Annual expenditures on all oncology drugs per new cancer case was significantly negatively correlated with the M/I ratio (Spearman's p = -0.90, p < .001). Conclusion. There is a financial threshold for oncology drugs per cancer case needed to increase survival. Based on significantly lower expenditures for oncology drugs in CEE in comparison with WE, more investment for drugs as well as better, more organized,value-oriented consumption is needed. Implications for Practice. Cancer is not treated equally successfully in Western Europe (WE) and in Central and Eastern Europe (CEE). This study showed that success in treatment of cancer is associated with the amount of money invested in oncology drugs. CEE countries spend on average 2.5 times less than WE countries for oncology drugs per new cancer case. These findings should be used by healthcare providers and oncologists struggling for more resources and better, more organized, evidence-based allocation of these resources as well as better oncology outcomes.
Ključne besede: neoplasms -- mortality -- epidemiology, incidence, pharmaceutical preparations -- economics, cancer, oncology, Central Europe, Eastern Europe, drug expenditures
Objavljeno v DiRROS: 26.10.2020; Ogledov: 1356; Prenosov: 310
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108. Worldwide perspectives on venom allergyPeter Korošec, Thilo Jakob, Harfi Harb, Robert Heddle, Sarah Karabus, Ricardo de Lima Zollner, Julij Šelb, Bernard Yu-Hor Thong, Fares Zaitoun, David B. K. Golden, Michael Levin, 2019, pregledni znanstveni članek Povzetek: Venom immunotherapy is the standard of care for people with severe reactions and has been proven to reduce risk of future anaphylactic events. There is a moral imperative to ensure production, supply and worldwide availability of locally relevant, registered, standardized commercial venom extracts for diagnosis and treatment. Insects causing severe immediate allergic reactions vary by region worldwide. The most common culprits include honeybees (Apis mellifera), social wasps including yellow jackets (Vespula and Dolichovespula), paper wasps (Polistes) and hornets (Vespa), stinging ants (Solenopsis, Myrmecia, Pachycondyla, and Pogonomyrmex), and bumblebees (Bombus). Insects with importance in specific areas of the world include the Australian tick (Ixodes holocyclus), the kissing bug (Triatoma spp), horseflies (Tabanus spp), and mosquitoes (Aedes, Culex, Anopheles). Reliable access to high quality venom immunotherapy to locally relevant allergens is not available throughout the world. Many current commercially available therapeutic vaccines have deficiencies, are not suitable for, or are unavailable in vast areas of the globe. New products are required to replace products that are unstandardized or inadequate, particularly whole-body extract products. New products are required for insects in which no current treatment options exist. Venom immunotherapy should be promoted throughout the world and the provision thereof be supported by health authorities, regulatory authorities and all sectors of the health care service.
Ključne besede: allergy and immunology, venoms, Hymenoptera, bee venoms, wasp venoms, insecta, ants hornet, bumblebee, mosquitoes, venom immunotherapy, immunologic desensitization
Objavljeno v DiRROS: 23.09.2020; Ogledov: 1785; Prenosov: 1064
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109. The impact of scald development on phenylpropanoid metabolism based on phenol content, enzyme activity, and gene expression analysisAnka Čebulj, Heidrun Halbwirth, Maja Mikulič Petkovšek, Robert Veberič, Ana Slatnar, 2020, izvirni znanstveni članek Ključne besede: scald, gene expression, hydroxycinnamic acids, color, enzyme activity, phenol content, scald development, apples, cold storage
Objavljeno v DiRROS: 03.09.2020; Ogledov: 1737; Prenosov: 547
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110. Drevesne naravne vrednote v registru naravnih vrednot SlovenijePia Caroline Adamič, Robert Brus, 2020, izvirni znanstveni članek Povzetek: Namen raziskave je bila podrobna analiza registra drevesnih naravnih vrednot Slovenije, ki vsebuje skupaj 2529 dreves in skupin dreves. V raziskavi smo prikazali deleže posameznih drevesnih vrst, njihov geografski izvor, merila vrednotenja, povprečne in največje mere drevesnih vrst, njihove lokacije in nahajališča ter poškodovanost dreves. Ugotovili smo, da je najpogostejša drevesna vrsta v registru lipa (42,67 % dreves) in da 87,4 % vseh dreves v registru pripada avtohtonim vrstam. Od tujerodnih vrst jih največ izvira iz Severne Amerike, po številu osebkov pa je tujerodnih vrst največ iz drugih delov Evrope. Najbolj pogosto merilo vrednotenja je izjemnost drevesa, predvsem obseg in višina, najdebelejše drevo v registru je Gašperjev kostanj (obseg 1104 cm), najvišje pa Sgermova smreka (višina 62 m). Največ izjemnih dreves raste ob domačijah in kmetijah (31,2 %) in v bližini sakralnih objektov (17,9 %). V registru je 36,3 % dreves brez evidentiranih poškodb, 59,6 % je poškodovanih, za 4,1 % pa ni podatka o poškodovanosti. Največja pogostnost dreves je v okolici Ljubljane in na Pohorju. Register vsebuje velik delež zastarelih podatkov, zato bi bilo treba narediti pregled aktualnega stanja drevesnih naravnih vrednot in ga dopolniti z novimi izjemnimi drevesi.
Ključne besede: drevesne naravne vrednote, register naravnih vrednot Slovenije, drevesna dediščina, izjemna drevesa
Objavljeno v DiRROS: 03.09.2020; Ogledov: 3840; Prenosov: 2236
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