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181.
Kombinacija obsevanja in žilno ciljane genske terapije za CD105 ter CD146
Monika Savarin, Maja Čemažar, Gregor Serša, 2022, objavljeni znanstveni prispevek na konferenci (vabljeno predavanje)

Ključne besede: obsevanje, genska terapija, klinične študije
Objavljeno v DiRROS: 17.06.2022; Ogledov: 477; Prenosov: 142
.pdf Celotno besedilo (94,30 KB)

182.
Imunska genska terapija in možnost kombiniranja z radioterapijo
Maja Čemažar, Gregor Serša, 2022, objavljeni znanstveni prispevek na konferenci (vabljeno predavanje)

Ključne besede: genska terapija, radioterapija, imunoterapija, eksperimentalna onkologija
Objavljeno v DiRROS: 16.06.2022; Ogledov: 481; Prenosov: 154
.pdf Celotno besedilo (147,02 KB)

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P14/ARF-positive malignant pleural mesothelioma : ǂa ǂphenotype with distinct immune microenvironment
Federica Pezzuto, Francesca Lunardi, Luca Vedovelli, Francesco Fortarezza, Loredana Urso, Federica Grosso, Giovanni Luca Ceresoli, Izidor Kern, Gregor Vlačić, Fiorella Calabrese, 2022, izvirni znanstveni članek

Povzetek: Introduction: The CDKN2A gene plays a central role in the pathogenesis of malignant pleural mesothelioma (MPM). The gene encodes for two tumor suppressor proteins, p16/INK4A and p14/ARF, frequently lost in MPM tumors. The exact role of p14/ARF in MPM and overall its correlation with the immune microenvironment is unknown. We aimed to determine whether there is a relationship between p14/ARF expression, tumor morphological features, and the inflammatory tumor microenvironment. Methods: Diagnostic biopsies from 76 chemo-naive MPMs were evaluated. Pathological assessments of histotype, necrosis, inflammation, grading, and mitosis were performed. We evaluated p14/ARF, PD-L1 (tumor proportion score, TPS), and Ki-67 (percentage) by immunohistochemistry. Inflammatory cell components (CD3+, CD4+, CD8+ T lymphocytes; CD20+ B-lymphocytes; CD68+ and CD163+ macrophages) were quantified as percentages of positive cells, distinguishing between intratumoral and peritumoral areas. The expression of p14/ARF was associated with several clinical and pathological characteristics. A random forest-based machine-learning algorithm (Boruta) was implemented to identify which variables were associated with p14/ARF expression. Results: p14/ARF was evaluated in 68 patients who had a sufficient number of tumor cells. Strong positivity was detected in 14 patients (21%) (11 epithelioid and 3 biphasic MPMs). At univariate analysis, p14/ARF-positive epithelioid mesotheliomas showed higher nuclear grade (G3) (p = 0.023) and higher PD-L1 expression (≥50%) (p = 0.042). The percentages of CD4 and CD163 in peritumoral areas were respectively higher and lower in p14/ARF positive tumors but did not reach statistical significance with our sample size (both p = 0.066). The Boruta algorithm confirmed the predictive value of PD-L1 percentage for p14/ARF expression in all histotypes. Conclusions: p14/ARF-positive epithelioid mesotheliomas may mark a more aggressive pathological phenotype (higher nuclear grade and PD-L1 expression). Considering the results regarding the tumor immune microenvironment, p14/ARF-negative tumors seem to have an immune microenvironment less sensitive to immune checkpoint inhibitors, being associated with low PD-L1 and CD4 expression, and high CD163 percentage. The association between p14/ARF-positive MPMs and PD-L1 expression suggests a possible interaction of the two pathways. Confirmation of our preliminary results could be important for patient selection and recruitment in future clinical trials with anticancer immunotherapy.
Ključne besede: lung -- cytology -- pathology, neoplasms, malignant mesothelioma, malignant pleural mesothelioma, tumor microenvironment
Objavljeno v DiRROS: 30.05.2022; Ogledov: 758; Prenosov: 492
.pdf Celotno besedilo (13,14 MB)
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186.
Electric-bus routes in hilly urban areas : overview and challenges
Gregor Papa, Marina Santo-Zarnik, Vida Vukašinović, 2022, izvirni znanstveni članek

Objavljeno v DiRROS: 27.05.2022; Ogledov: 607; Prenosov: 363
.pdf Celotno besedilo (14,45 MB)

187.
Study of water adsorption on EDTA-modified LTA zeolites
Janez Volavšek, O. L. Pliekhov, Olena Pliekhova, Gregor Mali, Nataša Zabukovec Logar, 2022, izvirni znanstveni članek

Ključne besede: 4A zeolite, 5A zeolite, LTA topology, water adsorption, EDTA dealumination, 27Al NMR, 29Si NMR
Objavljeno v DiRROS: 09.05.2022; Ogledov: 649; Prenosov: 392
.pdf Celotno besedilo (2,69 MB)
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188.
Brookite vs. rutile vs. anatase : what`s behind their various photocatalytic activities?
Gregor Žerjav, Krunoslav Žižek, Janez Zavašnik, Albin Pintar, 2022, izvirni znanstveni članek

Objavljeno v DiRROS: 05.05.2022; Ogledov: 613; Prenosov: 424
.pdf Celotno besedilo (6,26 MB)
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189.
Repository of drought event impacts across the danube catchment countries between 1981 and 2016 using publicly available sources
Jiří Jakubínský, Monika Bláhová, Lenka Bartošová, Klára Steinerová, Jan Balek, Petra Dížková, Daniela Semerádová, Daniel Alexandru, Galia Bardarska, Sabina Bokal, Gregor Gregorič, Gal Oblišar, Andreja Sušnik, 2019, izvirni znanstveni članek

Povzetek: Drought directly and indirectly affects human society in a number of ways. In many regions of the world climate change will exasperate the effects of droughts, affect national economies more intensely. The main aim of this article was to catalogue and analyze the drought impacts in the 11 Central and South Eastern European states located in the Danube river basin. The identification of dry episodes was based on information from publicly available sources, namely, newspaper and journal articles that reported drought impacts. Information on drought impact occurrences was classified into one of five defined categories in which the drought impact report was most clearly manifested (i.e., agriculture, forestry, soil systems, wildfires and hydrology). In terms of the spatial distribution of drought impacts, individual recorded events were analyzed at the level of EU NUTS regions (or their equivalent in non-EU countries). The analysis highlights country-specific vulnerability to drought. Furthermore, gradual increases in drought events and the number of reported impacts were identified, which was particularly evident in the agricultural sector.
Ključne besede: drought impact, Danube basin, agriculture, climate change, water stress
Objavljeno v DiRROS: 21.04.2022; Ogledov: 789; Prenosov: 355
.pdf Celotno besedilo (2,24 MB)
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190.
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