1. A second glass transition observed in single-component homogeneous liquids due to intramolecular vitrificationBen A. Russell, Mario González-Jiménez, Nikita V. Tukachev, Laure-Anne Hayes, Tajrian Chowdhury, Uroš Javornik, Gregor Mali, Manlio Tassieri, Joy H. Farnaby, Hans Martin Senn, Klaas Wynne, 2023, original scientific article Published in DiRROS: 09.01.2024; Views: 142; Downloads: 73
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2. Impact of dye encapsulation in ZIF-8 on ▫$CO_2$▫, water, and wet ▫$CO_2$▫ sorptionAljaž Škrjanc, Mojca Opresnik, Matej Gabrijelčič, Andraž Šuligoj, Gregor Mali, Nataša Zabukovec Logar, 2023, original scientific article Published in DiRROS: 06.11.2023; Views: 205; Downloads: 131
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3. Winning combination of Cu and Fe oxide clusters with an alumina support for low-temperature catalytic oxidation of volatile organic compoundsTadej Žumbar, Iztok Arčon, Petar Djinović, Giuliana Aquilanti, Alenka Ristić, Goran Dražić, Janez Volavšek, Gregor Mali, Margarita Popova, Nataša Zabukovec Logar, Nataša Novak Tušar, Albin Pintar, Gregor Žerjav, 2023, original scientific article Published in DiRROS: 23.06.2023; Views: 433; Downloads: 183
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4. Insight into the interdependence of Ni and Al in bifunctional Ni/ZSM-5 catalysts at the nanoscaleHue-Tong Vu, Iztok Arčon, Danilo Oliveira de Souza, Simone Pollastri, Goran Dražić, Janez Volavšek, Gregor Mali, Nataša Zabukovec Logar, Nataša Novak Tušar, 2022, original scientific article Keywords: Ni/ZSM-5 catalysts, zeolite, Ni XANES, EXAFS
Published in DiRROS: 13.06.2022; Views: 772; Downloads: 399
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5. Study of water adsorption on EDTA-modified LTA zeolitesJanez Volavšek, O. L. Pliekhov, Olena Pliekhova, Gregor Mali, Nataša Zabukovec Logar, 2022, original scientific article Keywords: 4A zeolite, 5A zeolite, LTA topology, water adsorption, EDTA dealumination, 27Al NMR, 29Si NMR
Published in DiRROS: 09.05.2022; Views: 669; Downloads: 400
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6. Effects of a mixed O/F ligand in the Tavorite-type LiVPO[sub]4O structureSorour Semsari Parapari, Jean-Marcel Ateba Mba, Elena Tchernychova, Gregor Mali, Iztok Arčon, Gregor Kapun, Mehmet Ali Gülgün, Robert Dominko, 2020, original scientific article Keywords: XRD, SEM, V XANES, Tavorite-type, electrochemical properties
Published in DiRROS: 25.11.2020; Views: 1591; Downloads: 879
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9. Comparative study of interactions of aliskiren and AT [sub] 1 receptor antagonists with lipid bilayersA. Sadegphour, Michael Rappolt, Dimitrios Ntountaniotis, Petros Chatzigeorgioug, Kyriakos Viras, Grigorios Megariotis, M. Papadopoulos, Eleni Siapi, Gregor Mali, Thomas Michael Mavromoustakos, 2015, original scientific article Abstract: The renin-angiotensin-aldosterone system (RAAS) plays a key role in the regulation of blood pressure. Renin is the rate limiting enzyme of the RAAS and aliskiren is a highly potent and selective inhibitor of the human renin. Renin is known to be active both in the circulating blood stream as well as locally, when bound to the (pro)-renin receptor ((P)RR). In this study we have investigated a possible mechanism of action of aliskiren, in which its accumulation in the plasma membrane is considered as an essential step for effective inhibition. Aliskiren's interactions with model membranes (cholesterol rich and poor) have been investigated by applying different complementary techniques: differential scanning calorimetry (DSC), Raman spectroscopy, magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and small- and wide-angle X-ray scattering (SAXS and WAXS). In addition, in silico molecular dynamics (MD) calculations were applied for further confirmation of the experimental data. Aliskiren's thermal effects on the pre- and main transition of dipalmitoyl-phosphatidylcholine (DPPC) membranes as well as its topographical position in the bilayer show striking similarities to those of angiotens.in II type 1 receptor (AT1R) antagonists. Moreover, at higher cholesterol concentrations aliskiren gets expelled from the membrane just as it has been recently demonstrated for the angiotensin receptor blocker (ARB) losartan. Thus, we propose that both the AT1R and the (P)RR-bound renin active sites can be efficiently blocked by membrane-bound ARBs and aliskiren when cholesterol rich membrane rafts/caveolae are formed in the vicinity of the receptors.
Keywords: aliskiren, renin, PRR, DPPC bilayers, raman spectroscopy, solid state NMR spectroscopy, SAXS and WAXS, MD simulations
Published in DiRROS: 26.01.2015; Views: 4303; Downloads: 296
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