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1.
Circulating serum sVCAM-1 concentration inadvanced ovarian cancer patients : correlation with concentration in ascites
Marina Jakimovska, Katarina Černe, Ivan Verdenik, Borut Kobal, 2014, izvirni znanstveni članek

Povzetek: Background. Vascular cell adhesion molecule-1 (VCAM-1) is associated with ovarian cancer progression but theorigin of its soluble form (sVCAM-1) in serum is not well investigated. The purpose of this study was to elucidate whetherthe concentration of sVCAM-1 in serum correlates with the concentration in ascites, that represents local tumour environment,and with systemic inflammation, various clinicopathological characteristics, and patient outcome.Patients and methods. Thirty-six patients with advanced ovarian cancer were included in the study. Serum forsVCAM-1 analysis was obtained prior to surgery. Ascites samples were collected at the beginning of the operation.Clinical data were collected from patients medical records. sVCAM-1 in samples was analysed by flow cytometricbead-based assay. The mean follow-up period was 11 months (range 0-23) from the time of surgery.Results. Serum sVCAM-1 concentrations are positively correlated to ascites sVCAM-1 concentrations. There was aweakly positive correlation of serum sVCAM-1 with tumour size and no correlation with inflammatory tumour markers,FIGO stage or grade. Higher concentrations of sVCAM-1 were associated with poor disease outcome (death fromovarian cancer) in almost all cases before chemotherapy was started.Conclusion. This is the first study demonstrating that serum concentrations of sVCAM-1 in advanced ovarian cancerpatients correlate with sVCAM-1 concentrations in ascites, thus expressing the biologic potential of malignant diseaseto metastasis, rather than systemic inflammation. Higher serum and ascites sVCAM-1 concentrations might have predictivepotential for different biologic behaviour.
Objavljeno v DiRROS: 16.04.2024; Ogledov: 74; Prenosov: 16
.pdf Celotno besedilo (491,78 KB)

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Uporaba energetskih inštrumentov pri kirurškem zdravljenju raka jajčnikov
Borut Kobal, 2023, objavljeni znanstveni prispevek na konferenci

Ključne besede: rak jajčnikov, kirurško zdravljenje, ginekološki raki
Objavljeno v DiRROS: 23.11.2023; Ogledov: 204; Prenosov: 102
.pdf Celotno besedilo (196,71 KB)
Gradivo ima več datotek! Več...

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Vloga ekstraabdominalne kirurgije pri napredovalem raku jajčnika
Borut Kobal, 2021, objavljeni znanstveni prispevek na konferenci (vabljeno predavanje)

Ključne besede: ginekološki raki, rak jajčnikov, onkološko zdravljenje
Objavljeno v DiRROS: 30.03.2022; Ogledov: 483; Prenosov: 231
.pdf Celotno besedilo (177,44 KB)
Gradivo ima več datotek! Več...

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Postopki za odkrivanje in obravnavo žensk s predrakavimi spremembami materničnega vratu
Marjetka Uršič-Vrščaj, Stelio Rakar, Andrej Možina, Borut Kobal, Iztok Takač, Dušan Deisinger, Andrej Zore, 2011, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid

Objavljeno v DiRROS: 10.06.2020; Ogledov: 1750; Prenosov: 472
.pdf Celotno besedilo (998,37 KB)

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