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Povzetek: Sorta ˈPendolinoˈ je dober opraševalec sorte ‘Leccino’ in ‘Frantoio’. Sama je avtosterilna in za dobro oploditev potrebuje opraševalca ('Leccino', 'Moraiolo', 'Frantoio'). Drevo je močne rasti z izrazito povešajočimi tanjšimi rodnimi vejami in ozkimi ozkimi listi. V novejših nasadih se je izkazala kot sorta, ki zgodaj stopi v rodnost. Plodovi se zgodaj obarvajo v črno in dozorevajo v istem času kot 'Leccino’. Rodnost je dobra in redna, po vsebnosti olja pa je nekoliko nižja od sorte ’Leccino’. Olje ima srednjo vsebnost tokoferolov in biofenolov. Sorta je malo občutljiva za pavje oko in sajavost, odporna pa na napade oljčne muhe in oljčnega molja. Nizke temperature sorazmerno dobro prenaša. Ključne besede: ˈPiangenteˈ, ˈMaurino fiorentinoˈ, ˈOlivo passerinoˈ
Ključne besede: oljka, sorte, Pendolino, oljčno olje
Objavljeno v DiRROS: 14.10.2022; Ogledov: 694; Prenosov: 274
Celotno besedilo (1,12 MB)
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Povzetek: Sorta ˈFrantoioˈ je v svetu razširjena zaradi sposobnosti prilagajanja na različna okolja ter redne in dobre rodnosti ter kakovosti olja. Drevo je bujne rasti, mladi poganjki so dolgi in povešeni. Dozorevanje plodov je postopno in traja dalj časa. Plodovi vsebujejo več olja od sorte Leccino, olje pa ima visoko vsebnost oleinske kisline, nizko vsebnost tokoferolov in visoko vsebnost biofenolov. Na pavje oko občutljiva, na in oljčno muho je pa malosrednje občutljiva , slabše pa prenaša nizke temperature, vendar se hitro obnavlja. Znana je njena velika občutljivost na oljčnega raka, ki je pogost spremljevalec te sorte. Zelo dobro prenaša Verticillium dahliae - verticilijsko uvelost. Ključne besede: ˈBresa finaˈ, ˈComuneˈ, ˈCorreggioloˈ, ˈCrognoloˈ, ˈFrantoianoˈ, ˈGentileˈ, ˈInfrantoioˈ, ˈLaurinoˈ, ˈNostratoˈ, ˈOliva lungaˈ, ˈPendaglioˈ, ˈPignatelloˈ, ˈRaggioˈ, ˈRaggioloˈ, ˈRazzoˈ
Ključne besede: oljka, sorte, Mata, oljčno olje
Objavljeno v DiRROS: 14.10.2022; Ogledov: 707; Prenosov: 285
Celotno besedilo (1,12 MB)
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Povzetek: The beneficial effects of electrochemotherapy (ECT) for superficial tumours and, more recently, deepseated malignancies in terms of local control and quality of life are widely accepted. However, the variability in responses across histotypes needs to be explored. Currently, patient selection for ECT is based on clinical factors (tumour size, histotype, and exposure to previous oncological treatments), whereas there are no biomarkers to predict the response to treatment. In this field, two major areas of investigation can be identified, i.e., tumour cell characteristics and the tumour microenvironment (vasculature, extracellular matrix, and immune infiltrate). For each of these areas, we describe the current knowledge and discuss how to foster further investigation. This review aims to provide a summary of the currently used guiding clinical factors and delineates a research roadmap for future studies to identify putative biomarkers of response to ECT. These biomarkers may allow researchers to improve ECT practice by customising treatment parameters, manipulating the tumour and its microenvironment, and exploring novel therapeutic combinations.
Ključne besede: biological factors, biomarkers, electrochemotherapy, bleomycin, cisplatin
Objavljeno v DiRROS: 23.09.2022; Ogledov: 543; Prenosov: 166
Celotno besedilo (1,32 MB)

Povzetek: In situ vaccination is a promising immunotherapeutic approach, where various local ablative therapies are used to induce an immune response against tumor antigens that are released from the therapy-killed tumor cells. We recently proposed using intratumoral gene electrotransfer for concomitant transfection of a cytotoxic cytokine tumor necrosis factor-% (TNF%) to induce in situ vaccination, and an immunostimulatory cytokine interleukin 12 (IL-12) to boost the primed immune response. Here, our aim was to test the local and systemic effectiveness of the approach in tree syngeneic mouse tumor models and associate it with tumor immune profiles, characterized by tumor mutational burden, immune infiltration and expression of PD-L1 and MHC-I on tumor cells. While none of the tested characteristic proved predictive for local effectiveness, high tumor mutational burden, immune infiltration and MHC-I expression were associated with higher abscopal effectiveness. Hence, we have confirmed that both the abundance and presentation of tumor antigens as well as the absence of immunosuppressive mechanisms are important for effective in situ vaccination. These findings provide important indications for future development of in situ vaccination based treatments, and for the selection of tumor types that will most likely benefit from it.
Ključne besede: in situ vaccination, gene electrotransfer, interleukin 12, tumor necrosis factor [alfa]
Objavljeno v DiRROS: 19.09.2022; Ogledov: 555; Prenosov: 184
Celotno besedilo (1,78 MB)

Povzetek: Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and the investigation of the interactions of different modalities. The aim of this study was two-fold. Firstly, to select the most effective combination of irradiation and the previously developed tumor cell-based vaccine and then to provide insight into the immune response to the selected combinatorial treatment. The study was performed in immunologically different murine tumor models: B16F10 melanoma and CT26 colorectal carcinoma. The most effective combinatorial treatment was selected by comparing three different IR regimens and three different vaccination regimens. We determined the local immune response by investigating immune cell infiltration at the vaccination site and in tumors. Lastly, we determined the systemic immune response by investigating the amount of tumor-specific effector lymphocytes in draining lymph nodes. The selected most effective combinatorial treatment was 5× 5 Gy in combination with concomitant single-dose vaccination (B16F10) or with concomitant multi-dose vaccination (CT26). The combinatorial treatment successfully elicited a local immune response at the vaccination site and in tumors in both tumor models. It also resulted in the highest amount of tumor-specific effector lymphocytes in draining lymph nodes in the B16F10, but not in the CT26 tumor-bearing mice. However, the amount of tumor-specific effector lymphocytes was intrinsically higher in the CT26 than in the B16F10 tumor model. Upon the selection of the most effective combinatorial treatment, we demonstrated that the vaccine elicits an immune response and contributes to the antitumor efficacy of tumor irradiation. However, this interaction is multi-faceted and appears to be dependent on the tumor immunogenicity.
Ključne besede: experimental oncology, multimodal treatment, radio-imunotherapy
Objavljeno v DiRROS: 14.09.2022; Ogledov: 575; Prenosov: 296
Celotno besedilo (9,70 MB)
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