1. Influence of surgical treatment and radiotherapy of the advanced intraoral cancers on complete blood count, body mass index, liver enzymes and leukocyte CD64 expressionTadej Dovšak, Alojz Ihan, Vojislav Didanovič, Andrej Kansky, Nataša Ihan Hren, 2009, izvirni znanstveni članek Povzetek: Background. The aim of our study was to evaluate the influence of the surgery and radiotherapy of the advanced oral squamous cell carcinoma on the complete blood count, body mass index (BMI), acute inflam-matory response, liver enzymes and expression of the CD64 index on leukocytes in the peripheral blood. Patients and method. Venous blood was obtained from 16 patients with advanced oral squamous cell carcinomas treated with radical surgery and external beam radiotherapy. Blood samples were collected prior to surgery (T1), after surgery (T2) and after radiotherapy (T3). Blood samples were analyzed for whole blood count, immunoglobulin G levels, liver enzymes (transaminases (ALT and AST) and gammaglutamyl trasferase (?-GT)), inflammatory response markers (C-reactive protein, erythrocyte sedimentation rate, albumin, white blood count, leukocyte count and CD64 expression on leukocytes). Assessment of nutrition was done by calculating the body mass index.Results. Surgery caused anaemia, trombocytosis, leukocytosis, lymphopenia, rise in acute phase proteins, elevation of CD64 expression on monocytes and neutrophyls, elevation of liver transaminases and lowering of ?-GT, albumin, protein and bilirubin levels. After radiotherapy haemoglobin, leukocytes, C-reactive protein, erythrocyte sedimentation rate, liver transferases, albumin, bilirubin and proteins returned almost to T1 levels, levels of lymphocytes, ?-GT and body mass index lowered. IgG levels remained almost unchanged at T2 and T3. Levels of the CD64 expression on monocytes and neutrophyls also elevated after radiotherapy.Conclusions. Surgery caused a significantly larger acute phase response than radiotherapy, while radiotherapy worsened the already present lymphopenia. Objavljeno v DiRROS: 08.03.2024; Ogledov: 161; Prenosov: 37 Celotno besedilo (117,17 KB) |
2. Combined therapy for oral cavity and oropharyngeal squamous cell carcinoma : depth of invasion as prognostic factorBogdan Čizmarevič, Boštjan Lanišnik, Vojislav Didanovič, Kristina Gornik-Kramberger, 2001, pregledni znanstveni članek Povzetek: Background. The aim of the study was to emphasize the importance of surgical management of squamous cell carcinoma (SCC) in the head and neck to find the most important predictive factor for cervical lymph node metastasis and prognostic factor for survival. The use of multimodality therapy is being discussed as well. Patients and methods. From June 1st, 1992 to May 31st, 1998, 154 patients with oral cavity and oropharyngeal SCC were admitted to the Department of Otorhinolaryngology and Cervicofacial Surgery in the Teaching Hospital of Maribor. The criteria for inclusion into the study were met by 142 patients, but only 62/142 patients entered the multimodality protocol (surgery and postoperative radiotherapy). These 62/142 patients were treated surgically and 49 of them were postoperatively irradiated, while 13/62 declined postoperative radiotherapy. Surgical specimen was evaluated for positive or negative lymph nodes, tumor margins and the depth of invasion. Tumor cells were stained for Ki67 proliferative factor. Results. The depth of invasion was the most important predictive factor for the neck metastases in multivariate model including also the grade, pT and T. pN was found to be important in determining the overall survival using Cox regression model (p>0,05). A statistically important discrepancy between N and pN classification was found. In 23 cases N was overrated and in 3 cases underrated. The overall 5-year disease specific survival was 55%. Ki67 correlated with the grade of tumor differentiation. No statistically significant correlation was found with lymph node metastases. Conclusions. The depth of invasion is the most important determining the occurrence of the neck metastases whereas the N status determines the survival. Objavljeno v DiRROS: 25.01.2024; Ogledov: 160; Prenosov: 38 Celotno besedilo (124,52 KB) |
3. Priporočila za zobozdravstveno obravnavo odraslih bolnikov z rakom glave in vratu v Sloveniji, zdravljenih z obsevanjemAleš Fidler, Aleksandar Aničin, Vojislav Didanovič, Tadej Dovšak, Boris Gašpirc, Aleš Grošelj, Andrej Kansky, Matic Koren, Jana Krapež, Hojka Kuralt, Marko Kuralt, Boštjan Lanišnik, Romana Mance Kristan, Jošt Pavčič, Luka Prodnik, Peter Pukl, Tadej Ostrc, Milan Kuhar, Eva Skalerič, Robert Šifrer, Valerija Skopec, Primož Strojan, 2022, izvirni znanstveni članek Povzetek: Priporočila za zobozdravstveno obravnavo bolnikov z rakom glave in vratu (RGV) v Sloveniji, zdravljenih z obsevanjem sledijo priporočilom The Royal College of Surgeons of England v sodelovanju z The British Society for Disability and Oral Health, dopolnjujejo Priporočila za obravnavo bolnikov z rakom glave in vratu v Sloveniji in hkrati upoštevajo obstoječe zmožnosti slovenskega zdravstvenega sistema. Namen priporočil je prepre-čevanje oz. zmanjšanje zapletov v ustni votlini, ki nastanejo zaradi obsevanja. Opredeljujejo način zobozdravstvene oskrbe pred, med in po zdravljenju raka na vseh treh nivojih zobozdra-vstvene oskrbe, kar zagotavlja njeno pravočasnost in dostopnost. Priporočila predstavljajo poenoteno mnenje vseh deležnikov na področju zobozdravstvene obravnave bolnikov z RGV v državi. Ključne besede: onkologija, zobozdravstvena obravnava, obsevanje, ustna votlina, priporočila Objavljeno v DiRROS: 14.07.2022; Ogledov: 620; Prenosov: 213 Celotno besedilo (1,45 MB) |
4. Kaj morate vedeti o zdravilu denosumabTanja Ovčariček, Erika Matos, Nataša Snoj Šarvari, Vojislav Didanovič, 2020, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid Ključne besede: kemoterapija, kostni zasevki, denosumab Objavljeno v DiRROS: 14.07.2022; Ogledov: 612; Prenosov: 189 Celotno besedilo (323,99 KB) |
5. Priporočila za obravnavo bolnikov z rakom glave in vratu v SlovenijiPrimož Strojan, Aleksandar Aničin, Jelena Azarija, Saba Battelino, Bogdan Čizmarevič, Vojislav Didanovič, Tadej Dovšak, Marta Dremelj, Aleš Fidler, Matic Glavan, Cvetka Grašič-Kuhar, Aleš Grošelj, Andrej Kansky, Katarina Barbara Karner, Marko Kokalj, Matic Koren, Jana Krapež, Hojka Kuralt, Boštjan Lanišnik, Primož Levart, Jure Orel, Jošt Pavčič, Gaber Plavc, Luka Prodnik, Peter Pukl, Robert Šifrer, Matija Švagan, Jure Urbančič, Branko Zakotnik, Nina Zidar, Barbara Žumer, 2021, strokovni članek Povzetek: Priporočila za obravnavo rakov glave in vratu (RGV) v Sloveniji sledijo priporočilom in usmeritvam, povzetim v publikaciji neprofitne mreže 30 vodilnih severnoameriških inštitucij za obravnavo raka, National Comprehensive Cancer Network,1 in hkrati upoštevajo obstoječe zmožnosti slovenskega zdravstvenega sistema. Smernice predstavljajo poenoteno mnenje vseh štirih najpomembnejših deležnikov na področju obravnave rakov glave in vratu v državi: Klinike za otorinolaringologijo in cervikofacialno kirurgijo, Kliničnega oddelka za maksilofacialno in oralno kirurgijo ter Stomatološke klinike UKC Ljubljana, Klinike za otorinolaringologijo, cervikalno in maksilofacialno kirurgijo UKC Maribor ter Onkološkega inštituta Ljubljana Ključne besede: rak glave in vratu, zdravljenje, onkolško zdravljenje Objavljeno v DiRROS: 11.06.2021; Ogledov: 1603; Prenosov: 384 Celotno besedilo (258,88 KB) |
6. Priporočila za obravnavo rakov glave in vratu v SlovenijiAleksandar Aničin, Saba Battelino, Bogdan Čizmarevič, Vojislav Didanovič, Tadej Dovšak, Marta Dremelj, Aleš Fidler, Matic Glavan, Cvetka Grašič-Kuhar, Aleš Grošelj, Andrej Kansky, Katarina Barbara Karner, Marko Kokalj, Matic Koren, Jana Krapež, Hojka Kuralt, Boštjan Lanišnik, Primož Levart, Janez Orel, Janez Pavčič, Gaber Plavc, Luka Prodnik, Peter Pukl, Robert Šifrer, Matija Švagan, Jure Urbančič, Branko Zakotnik, Nina Zidar, Barbara Žumer, 2020, slovar, enciklopedija, leksikon, priročnik, atlas, zemljevid Ključne besede: rak glave in vratu, priporočila, zdravljenje Objavljeno v DiRROS: 12.03.2021; Ogledov: 1435; Prenosov: 397 Celotno besedilo (1,13 MB) |
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9. Slovenska priporočila za obravnavo kaheksije pri bolnikih z rakomNada Rotovnik-Kozjek, Živa Mrevlje, Barbara Koroušić-Seljak, Katja Kogovšek, Branko Zakotnik, Iztok Takač, Matjaž Horvat, Tadej Dovšak, Vojislav Didanovič, Andrej Kansky, Jožica Červek, Vaneja Velenik, Franc Anderluh, Milena Kerin, Matjaž Sever, Primož Strojan, Borut Štabuc, Mojca Unk, Jernej Benedik, Erik Brecelj, Tadeja Pintar, Lidija Kompan, Marko Novak, Laura Petrica, Denis Mlakar-Mastnak, Brigita Avramović Brumen, Eva Peklaj, Rajmonda Jankovič, Urška Jelenko, Edita Rotner, Sanja Đukić, Petra Tavčar, 2012, objavljeni strokovni prispevek na konferenci Ključne besede: onkologija, kaheksija, priporočila, klasifikacija Objavljeno v DiRROS: 17.09.2019; Ogledov: 2539; Prenosov: 747 Celotno besedilo (158,92 KB) |