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42. Pomen izvora raziskovalnih podatkov (provenience) pri interoperabilnosti in ponovni uporabi : spletni dogodek v okviru Odprte akademije, 24. jan. 2022Mitja Vovk Iskrić, Petra Durini, Maja Vihar, Uroš Kunaver, Miro Pušnik, Maja Peteh, Nana Turk, Darko Majcenović, 2022, strokovni film, videoposnetek ali zvočni posnetek Objavljeno v DiRROS: 24.01.2023; Ogledov: 494; Prenosov: 194
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43. Odprta znanost v programu Obzorje Evropa : diseminacija, temeljna načela odprte znanosti, odprti dostop, ravnanje z raziskovalnimi podatki, Ravnanje z raziskovalnimi podatkiPetra Durini, Maja Vihar, Nana Turk, Uroš Kunaver, Mitja Vovk Iskrić, Tilen Mandelj, Miro Pušnik, 2022, strokovni film, videoposnetek ali zvočni posnetek Objavljeno v DiRROS: 24.01.2023; Ogledov: 417; Prenosov: 133
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46. Odprta znanost v programu Obzorje Evropa : razširjanje rezultatov, temeljna načela odprte znanosti, odprti dostopMitja Vovk Iskrić, Maja Vihar, Petra Durini, Uroš Kunaver, Miro Pušnik, 2021, strokovni film, videoposnetek ali zvočni posnetek Ključne besede: znanstveno raziskovanje, odprta znanost, knjižnično informacijska dejavnost, podpora raziskovalcem, Obzorje Evropa
Objavljeno v DiRROS: 05.01.2023; Ogledov: 471; Prenosov: 136
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48. Effects of meditation on cardiovascular and muscular responses in patients during cardiac rehabilitation : a randomized pilot studyMaximilian E. Rudlof, Boštjan Šimunič, Bianca Steuber, Till O. Bartel, Ruslan Neshev, Petra Mächler, Andreas Dorr, Rainer Picha, Karin Schimd-Zalaudek, Nandu Goswami, 2022, izvirni znanstveni članek Povzetek: Background: Cardiovascular diseases are the world’s number one cause of death, with exceeding psychosocial stress load being considered a major risk factor. A stress management technique that has repeatedly shown positive effects on the cardiovascular system is the Transcendental Meditation (TM) technique. The present pilot study aimed to investigate the potential effect of TM on the recovery of cardiac patients. Objectives: We hypothesized that practicing TM in patients undergoing a 4-week cardiac rehabilitation program augments the recovery of cardiovascular parameters and reduces skeletal muscle tone after rehabilitation. Methods: Twenty cardiac patients were recruited and randomly assigned to either the control or the TM group. Cardiovascular parameters were assessed with the Task Force Monitor (TFM) and skeletal muscle contractile properties by Tensiomyography during a sit-stand test, performed at the beginning and end of a 4-week in-patient rehabilitation program. Results: Systolic blood pressure (SBP) was significantly lower after 4 weeks of cardiac rehabilitation, while the RR-interval (RRI) significantly increased. At the skeletal muscle level, the contraction time and maximal displacement increased, though only in the gastrocnemius medialis and biceps femoris muscles and not in vastus lateralis. Group interactions were not observed for hemodynamic parameters nor for muscle contractile properties. Discussion: Although significant improvements in hemodynamic and muscular parameters were observed after 4 weeks of rehabilitation, we could not provide evidence that TM improved rehabilitation after 4 weeks. TM may unfold its effects on the cardiovascular system in the longer term. Hence, future studies should comprise a long-term follow-up.
Ključne besede: cardiovascular diseases, psychosocial stress, transcendental meditation, cardiac rehabilitation, tensiomyography
Objavljeno v DiRROS: 28.10.2022; Ogledov: 402; Prenosov: 258
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49. Combination of pembrolizumab with electrochemotherapy in cutaneous metastases from melanoma : a comparative retrospective study from the InspECT and Slovenian Cancer RegistryLuca Giovanni Campana, Barbara Perić, Matteo Mascherini, Romina Spina, Christian Kunte, Erika Kis, Petra Rozsa, Pietro Quaglino, Maja Čemažar, Maša Omerzel, Gregor Serša, 2021, izvirni znanstveni članek Povzetek: Electrochemotherapy (ECT) is an effective locoregional therapy for cutaneous melanoma metastases and has been safely combined with immune checkpoint inhibitors in preliminary experiences. Since ECT is known to induce immunogenic cell death, its combination with immune checkpoint inhibitors might be beneficial. In this study, we aimed to investigate the effectiveness of ECT on cutaneous melanoma metastases in combination with pembrolizumab. We undertook a retrospective matched cohort analysis of stage IIIC%IV melanoma patients, included in the International Network for sharing practices of ECT (InspECT) and the Slovenian Cancer Registry. We compared the outcome of patients who received the following treatments: (a) pembrolizumab alone, (b) pembrolizumab plus ECT, and (c) ECT. The groups were matched for age, sex, performance status, and size of skin metastases. The local objective response rate (ORR) was higher in the pembrolizumab-ECT group than in the pembrolizumab group (78% and 39%, p < 0.001). The 1 year local progression-free survival (LPFS) rates were 86% and 51% (p < 0.001), and the 1 year systemic PFS rates were 64% and 39%, respectively (p = 0.034). The 1 year overall survival (OS) rates were 88% and 64%, respectively (p = 0.006). Our results suggest that skin-directed therapy with ECT improves superficial tumor control in melanoma patients treated with pembrolizumab. Interestingly, we observed longer PFS and OS in the pembrolizumab-ECT group than in the pembrolizumab group. These findings warrant prospective confirmation.
Ključne besede: electrochemotherapy, metastatic melanoma, skin metastases
Objavljeno v DiRROS: 10.10.2022; Ogledov: 464; Prenosov: 230
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