1. Neoadjuvant chemotherapy in 13 patients with locally advanced poorly differentiated thyroid carcinoma based on Turin proposal : a single institution experienceNikola Bešić, Marta Dremelj, Andreja A. Schwarzbartl-Pevec, Barbara Gazić, 2015, izvirni znanstveni članek Povzetek: There is a paradigm that chemotherapy is ineffective in thyroid carcinoma. The aim of our study was to find out whether neoadjuvant chemotherapy before thyroid surgery had an effect on the size of primary tumour in patients with poorly differentiated thyroid carcinoma (PDTC) based on Turin proposal. Patients and methods. Altogether, 13 patients (8 women, 5 men; median age 61 years) with PDTC based on Turin proposal were treated with neoadjuvant chemotherapy between 1986 and 2005. Tumour diameter was from 4.5 to 18 cm (median 9 cm). Regional and distant metastases were detected in 6 and 9 patients, respectively. Eight patients had pT4 tumour. Results. Altogether, 29 (range 1%5) cycles of chemotherapy were given. Tumour diameter decreased in all the patients and by more than 30% in 5 patients (= 38%). Two of these five patients had also preoperative external beam irradiation (EBRT). Total thyroidectomy, lobectomy and neck dissection were performed in 10, 3 and 5 cases, respectively. R0 and R1 resection was done in 5 and 8 cases, respectively. Eight patients had postoperative EBRT of the neck and upper mediastinum. The 5-year and 10-year cause-specific survival rates of patients were 66% and 20%, respectively. Conclusions. After neoadjuvant chemotherapy a partial tumour regression was observed in 38% of patients with PDTC based on Turin proposal.
Ključne besede: poorly differentiated thyroid carcinoma, neoadjuvant, chemotherapy, survival
Objavljeno v DiRROS: 22.04.2024; Ogledov: 21; Prenosov: 5
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2. Comparison of continuous local anaesthetic and systemic pain treatment after axillary lymphadenectomy in breast carcinoma patients - a prospective randomized studyBranka Stražišar, Nikola Bešić, 2013, izvirni znanstveni članek Povzetek: Background. Acute pain after axillary lymphadenectomy is often related mainly to axillary surgery. The aim of the prospective randomized study was to find out if continuous wound infusion of local anaesthetic reduces postoperative pain, consumption of opioids and the incidence of chronic pain compared to the standard intravenous piritramide analgesia after axillary lymphadenectomy in breast carcinoma patients. Methods. Altogether 60 patients were enrolled in the prospective randomized study; half in wound infusion of local anaesthetic and half in the standard (piritramide) group. Results. In the recovery room and on the first day after surgical procedure, the wound infusion of local anaesthetic group reported less acute and chronic pain, a lower consumption of piritramide and metoclopramide, but their alertness after the surgical procedure was higher compared to the standard group. Conclusions. After axillary lymphadenectomy in breast carcinoma patients, wound infusion of local anaesthetic reduces acute pain and enables reduced opioid consumption, resulting in less postoperative sedation and a reduced need for antiemetic drugs. After wound infusion of local anaesthetic there is a statistical trend for reduction of chronic pain.
Ključne besede: breast carcinoma, pain treatment, acute pain
Objavljeno v DiRROS: 22.03.2024; Ogledov: 86; Prenosov: 35
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3. Effectiveness of L-thyroxine treatment on TSH suppression during pregnancy in patients with a history of thyroid carcinoma after total thyroidectomy and radioiodine ablationBlaž Krhin, Nikola Bešić, 2012, izvirni znanstveni članek Povzetek: Introduction. There are scarce data about the optimal increase of L-thyroxine dose during pregnancy in patients with a history of thyroid carcinoma. The first aim of the study was to find out if routine therapeutic measures enable adequate TSH suppression in pregnancy. The other aim was to find out the optimal dose of L-thyroxine for TSH suppression in pregnant women. Patients and methods. In this retrospective observational study, we analysed 36 pregnancies of 32 women with a history of thyroid carcinoma. Before pregnancy, all of them underwent total thyroidectomy and radioiodine ablation of thyroid remnant, and they were on suppressive doses of L-thyroxine. Thyroid function tests were obtained before, during and after pregnancy. Results. Mean L-thyroxine dose before pregnancy, in the first, second and, third trimester and after delivery was 149, 147, 155, 165 and 158 micrograms daily, respectively. TSH concentration remained suppressed in 9 pregnancies, it was within normal range in 22 and elevated in 5 pregnancies. The mean dose of L-thyroxine in patients with suppressed TSH before pregnancy, in the first, second and, third trimester and after delivery was 154, 154, 164, 160 and 161 micrograms daily, respectively. When the dose had to be changed, the mean increase of the dose was 31.5 micrograms daily. Conclusions. The range of changes in TSH concentration during pregnancy in the patients who have been on suppressive L-thyroxine therapy before conception is quite wide. TSH was adequately suppressed in only 25% of pregnancies. The dose of L-thyroxine in patients with suppressed TSH in the first, second and third trimester was 154, 164 and 160 micrograms daily, respectively.
Objavljeno v DiRROS: 21.03.2024; Ogledov: 69; Prenosov: 24
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4. Influence of magnesium sulphate infusion before total thyroidectomy on transient hypocalcemia - a randomised studyNikola Bešić, Špela Žagar, Gašper Pilko, Barbara Perić, Marko Hočevar, 2008, izvirni znanstveni članek Povzetek: Background. Transient hypocalcemia is the most common complication after thyroidectomy. Normomagnesemia is needed for normal secretion of PTH and end-organ responsiveness. Our aim was to determine the influence of infusion of magnesium sulphate before thyroidectomy on the incidence of laboratory and clinical transient hypocalcemia. Methods. In our prospective study, 48 patients (5 men, 43 women; age 22-73 years, median 45 years), who underwent total or near-total thyroidectomy, were randomised preoperatively. Half of them received intravenously 4 ml of 1M magnesium sulphate at the beginning of the surgical procedure, the other half were the control group. Serum concentrations of calcium, ionised calcium, magnesium, phosphate, albumin and PTH were measured prior to surgery and on the first day after surgery. Results. Laboratory postoperative hypocalcemia was present in 27% of patients and 23% of patients had clinical signs and/or symptoms of postoperative hypocalcemia. The concentration of total calcium (p=0.024) and of albumin (p=0.01) was lower in the group that received magnesium sulphate. Conclusions.The patients who received infusion of magnesium sulphate before total thyroidectomy had lower concentration of total serum calcium and albuminin comparison to the control group. There was no statistical differencein the incidence of clinical transient hypocalcemia.
Objavljeno v DiRROS: 08.03.2024; Ogledov: 89; Prenosov: 25
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8. Infestation intensity by the invasive oak lace bug, Corythucha arcuata (Say) in mixed and pure oak standsGernot Hoch, Alex Stemmelen, Eötvös Csaba Béla, Werner Hinterstoisser, Miran Lanšćak, Srđan Stojnić, Máté Tóth, Marjana Westergren, Simon Zidar, Milica Zlatković, Nikola Zoric, Maarten De Groot, 2024, izvirni znanstveni članek Povzetek: There has been accumulating evidence for effects of tree species composition on herbivory with many examples of lower damage by specialist feeders in tree species rich forests. In a joint study in five Central and Southeastern European countries, we studied the effect of tree species richness on infestation intensity of the oak lace bug, Corythucha arcuata (Say) (Heteroptera, Tingidae), an invasive pest on oak trees that has spread rapidly across the Balkan Peninsula and Central Europe. Intensity of infestation by C. arcuata on oaks was assessed on three or four study plots with high (pure stands) and three or four plots with low percentage of oak (mixed stands) in each country. Ordinal regression analysis showed that intensity of infestation of trees by C. arcuata differed between countries; no significant effect of stand type (mixed or pure) on infestation levels was detected. When analysing the percentage of trees in the highest infestation class, stand type had a significant effect with more intensive infestation in pure stands. We conclude that mixed stands will not prevent severe infestation but may help mitigating the impact of established C. arcuata populations.
Ključne besede: associational resistance, Corythucha arcuata, diversity, host tree concentration, invasive forest pest
Objavljeno v DiRROS: 14.11.2023; Ogledov: 289; Prenosov: 176
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10. Study of different types of copper electrodes for anodic stripping voltammetric detection of trace metal ionsDomen Obrez, Mitja Kolar, Nikola Tasić, Samo B. Hočevar, 2023, izvirni znanstveni članek Ključne besede: copper film electrode, copper bulk electrode, copper wire electrode, lead and cadmium, anodic stripping voltammetry
Objavljeno v DiRROS: 07.08.2023; Ogledov: 304; Prenosov: 177
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