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Iskalni niz: "avtor" (��trukelj Borut) .

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1.
Microsatellite instability in colorectal cancer
Matej Horvat, Borut Štabuc, 2011, pregledni znanstveni članek

Povzetek: Background. Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequenceof inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis colorectal cancer (HNPCC) represents 10-20%. Microsatellite sequences (MS) arerepeated sequences of short stretches of DNA all over the genome. Microsatellite stability (MSS) means MS are the same in each cell of an individual, whereas microsatellite instability (MSI-H) means MS differ in normal and cancer cells of an individual. The cause of MSI-H is a damaged mismatch repair mechanism (MMR), with the most important MMR proteins being MSH2, MLH1 and MSH6. Conclusions. MSI-H seems to be an important prognostic factor in CRC and an important predictive factor of CRC chemotherapeutic treatment efficacy. Clinical trials conducted until now have shown contradictory findings in different chemotherapeutic settings, adjuvant and palliative; therefore MSI-H is going to be the object of the future research. The future of cancer treatment is in the individualized therapy based on molecular characteristics of the tumour, such as MSI-H in CRC.
Objavljeno v DiRROS: 19.03.2024; Ogledov: 66; Prenosov: 37
.pdf Celotno besedilo (489,56 KB)
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2.
Increased late urinary toxicity with whole pelvic radiotherapy after prostatectomy
Borut Kragelj, 2009, izvirni znanstveni članek

Povzetek: Background. Radiotherapy aimed at prostatic bed (PBRT) can prevent recurrence or reestablish remission in prostate cancer patients primarily treated with prostatectomy. In selected patients results may be improved with the additional irradiation of pelvic nodes (WPRT). Patients and methods. The objective of the study was to evaluate late toxicity of postoperative radiotherapy in 43 patients - 21/43 treated with WPRT. Dysuria, haematuria, nocturia, continence and obstructive urination problems as well as urgency, continence, frequency, pain and bleeding of defecations were prospectively registered and converted to a modified Radiation Therapy Oncology Group (RTOG)- late effects normal tissue (LENT) scoring system. Median tumour dose (TD) for PBRT was 64.8 (59.4-70.0) Gy and for WPRT 50.4 (48.0-56.0) Gy. Results. More important than the deterioration of intestinal function (worsening for 1 grade in 54% and >= 2 grades in 5% of patients) was the deterioration of urinary function (worsening for 1 grade in 33% and >= 2 grades in 26% of patients). This appeared to be more frequent in patients withWPRT than PBRT (67% vs. 50% of patients) especially in conjunction with WPRT TD > 52 Gy (deterioration in 71% of patients). Conclusions. Although several factors may influence increased urinary toxicity after WPRT, it seems reasonable to lower the urinary bladder dose as it possible with novel radiation techniques.
Objavljeno v DiRROS: 08.03.2024; Ogledov: 62; Prenosov: 15
.pdf Celotno besedilo (83,78 KB)

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Irradiation of regionally advanced carcinoma of the penis
Borut Kragelj, 2009, izvirni znanstveni članek

Objavljeno v DiRROS: 08.03.2024; Ogledov: 51; Prenosov: 20
.pdf Celotno besedilo (61,76 KB)

5.
Dry-sliding wear resistance of AISI H11-type hot-work tool steel
Gašper Puš, Borut Žužek, Agnieszka Guštin, Bojan Podgornik, 2023, izvirni znanstveni članek

Ključne besede: hot-work tool steel, friction, sliding wear, mechanical properties
Objavljeno v DiRROS: 08.03.2024; Ogledov: 63; Prenosov: 37
.pdf Celotno besedilo (2,04 MB)
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6.
Small-bowel carcinoid presenting with acute bleeding detected upon wireless capsule endoscopy
Živa Mrevlje, Marko Sever, Borut Kocijančič, 2005, izvirni znanstveni članek

Povzetek: Background. Intestine carcinoid usually presents with clinical symptoms and signs deriving from its endocrinological influences and rarely bleeds profusely. Case report. We present a patient with intestinal bleeding of unknown origin. After conventional diagnostic procedures only wireless capsuleendosopy was able to discover a tumour of small bowel, which was the reason of bleeding. On patohistological examination after the surgical resection it proved to be a small bowel carcinoid. Conclusions. There are indications that WCE, besides being the first small bowel imaging technique, is a very important diagnostic tool, deserving consideration in the early phases of diagnosing small-bowel disease, especially in less intensive or occult bleeding.
Objavljeno v DiRROS: 14.02.2024; Ogledov: 110; Prenosov: 21
.pdf Celotno besedilo (150,49 KB)

7.
Setup and its effect on safety margin in conformal radiotherapy of the prostate
Borut Kragelj, 2005, izvirni znanstveni članek

Povzetek: Background. In radiotherapy, setup errors in positioning the patients influence the size of safety margin and thereby also the size of irradiation field and toxicity of radiotherapy. Methods. The setup errors were calculated by evaluating the deviations from the measured distance between the irradiation field margin and the bony pelvis. Results. The research was performed on 23 patients. With respect to lateral, craniocaudal and anteroposterior axis, the observed systemic error ranged from -5 to + 9 mm, -4to +5 mm, and from -4 to +4 mm, respectively, whereas the observed random error ranged from 0 to 7.5 mm, 0 to 3.6 mm, and from 0 to 4.2 mm, respectively. The safety margin, with the 90% probability to cover clinical target volume (CTV) and allowing for the prostate position variability, measured 9 mm, 9.5 mm, 7 mm, and 10 mm in the respective lateral, craniocaudal, anterior and dorsal direction. Conclusions. Irradiation of the prostate with a 7 mm dorsal safety margin, allowing for 90% coverage probability of CTV, was feasible in 22/23 patients on condition that the grosssystemic error (>3mm) was eliminated.
Objavljeno v DiRROS: 14.02.2024; Ogledov: 109; Prenosov: 25
.pdf Celotno besedilo (90,40 KB)

8.
Mechanisms of premature fracture in modular neck stems made of CoCrMo/Ti6Al4V and Ti6Al4V/Ti6Al4V alloy
Drago Dolinar, Miro Gorenšek, Klemen Avsec, Barbara Šetina, Matej Hočevar, Matjaž Godec, Borut Žužek, Mojca Debeljak, Monika Jenko, John T. Grant, Boštjan Kocjančič, 2023, izvirni znanstveni članek

Povzetek: In this paper, we present the mechanisms of premature fracture of modular neck stems in two case studies: (I) when the neck and stem are both made of the same Ti6Al4V alloy, and (II) when the neck and stem are made from two different alloys, CoCrMo and Ti6Al4V alloy. Our study integrates two orthopedic patients who have undergone primary uncemented THA for usual indications in two orthopedic centers (Community Health Centre and University Medical Centre). Both centers are part of the national public health care system. Both surgeries were performed by two skilled orthopedic surgeons with more than 10 years of experience in THA. The survivorship of the modular neck of cast CoCrMo alloy was 24 months. The survivorship of the modular neck from Ti6Al4V alloy was 84 months. Multivariate analyses were performed to assess the differences in the fretting, corrosion, and fatigue of the two prematurely failed modular neck stems: stereo light microscopy (SLM), scanning electron microscopy (SEM), X-ray energy-dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD). Patient demographic information, including sex, age, body mass index, survivorship of implants, and reason for the revision, was collected from medical records. We found that fretting and fatigue occurred on both neck-stem retrievals due to additional galvanic corrosion, but the CoCrMo/Ti6Al4V alloy system suffered more corrosion due to additional galvanic corrosion and fractured earlier than the Ti6Al4V/Ti6Al4V metal alloy system. Both metallic alloy systems used in this application are known to be highly corrosion-resistant, but the bio-tribo-corrosion processes need to be understood in detail and characterized so that appropriate improvements in design and materials can be made.
Ključne besede: total hip arthroplasty, modular neck, Ti6Al4V alloy, CoCrMo alloy, corrosion
Objavljeno v DiRROS: 07.02.2024; Ogledov: 174; Prenosov: 87
.pdf Celotno besedilo (5,12 MB)
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9.
The urokinase plasminogen activator and its inhibitors PAI-1 nad PAI-2 in primary cutaneous melanoma
Jasmina Markovič Božič, Borut Štabuc, 2003, izvirni znanstveni članek

Povzetek: Background. We investigated the differences in urokinase plasminogen activator(uPA) and its inhibitors type-1 and 2 (PAI-1/2) concentrations in clinically suspected nevi, primary cutaneous melanoma and normal skin and correlations with histopathological prognostic factors of primary melanoma. Patients and methods. Fifty-one patients were enrolled. The tissue concentrations of uPA, PAI 1 and PAI2 were quantified by enzyme-linked immunosorbent assay (ELISA). Results. Mean uPA and PAI-1 concentrations in melanomas were higher than in normal surrounding skin (uPA: 1.08; vs. 0.48 ng/mgp; PAI-1: 14.07 vs. 2.07 ng/mgp; p < 0.001), uPA and PAI-1 concentrationswere higher in melanomas than in nevi, and higher in nevi than in normal surrounding skin (uPA: p > 0.05; PAI-1: p = 0.02). PAI-2 concentration was higher in normal surrounding skin than in nevi and melanomas(p > 0.05). Melanoma uPA, PAI-1 and PAI-2 concentrations correlated significantly with normal skin (r= 0.73, 0.54, 0.38 respectively). PAI 1 was significantly lower in melanomas of Breslow thickness < 0.75 mm, Clark invasion of O+I, without microscopic ulceration, without vascular invasion (p < 0.01) than in melanomas of Breslow thickness > 0.75 mm, Clark invasion > II,with ulceration and vascular invasion. Conclusions. Determination of uPA and PAI-1 can provide significant additional prognostic information for melanoma patients.
Objavljeno v DiRROS: 06.02.2024; Ogledov: 102; Prenosov: 24
.pdf Celotno besedilo (231,89 KB)

10.
Preliminary study of new low-temperature hard abrasion resistant Fe-P and Fe-P-X (X = C or/and B) casting alloys
Matija Zorc, Aleš Nagode, Jaka Burja, Borut Kosec, Milan Bizjak, Borut Zorc, 2023, izvirni znanstveni članek

Objavljeno v DiRROS: 02.02.2024; Ogledov: 126; Prenosov: 52
.pdf Celotno besedilo (9,44 MB)
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